Probiotics and fructo-oligosaccharide intervention modulate the microbiota-gut brain axis to improve autism spectrum reducing also the hyper-serotonergic state and the dopamine metabolism disorder

Wang, Ying; Li, Ning; Yang, Junjie; Zhao, Dongmei; Chen, Bin; Zhang, Guoqing; Chen, Shuo; Cao, Ruifang; Yu, Han; Zhao, Chuanzhi; Zhao, Lu; Ge, Yongsheng; Liu, Yi; Zhang, Le-Hai; Hu, Wei; Zhang, Lei; Gai, Zhongtao

doi:10.1016/j.phrs.2020.104784

Cited by 175 publications

(174 citation statements)

References 60 publications

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“…This is not consistent with our results, possibly due to the difference in pathological degree caused by the different modeling times or the different sampling areas, animal species, feeding conditions, and other factors. However, the investigation in the population shows that the butyric acid content of autistic patients is significantly down-regulated ( Wang et al, 2020 ). Besides, we noted a significant correlation between the levels of SCFAs (butyrate acid, acetic acid, isobutyric acid, valeric acid, and isovaleric acid) and autistic-like behaviors in VPA-treated group, indicating that regulating the composition of SCFA-producing gut microbiota or directly supplementing the corresponding proportion of SCFAs might be a potential strategy to alleviate the neurological damage and behavioral abnormalities in autism.…”

Section: Discussionmentioning

confidence: 99%

The autistic-like behaviors development during weaning and sexual maturation in VPA-induced autistic-like rats is accompanied by gut microbiota dysbiosis

Kong

Tian

Zhao

et al. 2021

PeerJ

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Researches on gut microbiota in autism have mostly focused on children, but the dynamic changes of gut microbiota from weaning to adulthood were still not clear because of the difficulty of diagnosing autism. In this study, autistic-like rats indued by valproate (VPA) were tracked from weaning (end of breastfeeding; four weeks old) to sexual maturation (food; eight weeks old). Autistic-like rats were found to show obvious developmental disorders. During weaning, autistic-like rats only exhibited obvious repetitive stereotyped behaviors, but the autistic-like behaviors were fully apparent upon sexual maturation. Significant differences were observed between the gut microbiota of autistic-like and healthy rats across both age groups. The correlation analysis results revealed that the correlation between behaviors and some microbiota, especially Helicobacter, did not vary with age or diet. The total amount of short-chain fatty acids (SCFAs) decreased, butyric acid metabolism decreased, and propionic acid metabolism increased in the feces of autistic-like rats. The correlation between autistic-like behaviors and the butyric acid and propionic acid levels did not vary with diet or age. Inositol phosphate metabolism, amino acid metabolism, and lipopolysaccharide biosynthesis were significantly associated with autistic-like behaviors. Our results showed that although the microbiota and SCFAs related to autism were affected by age and diet, some remained consistent irrespective of age and diet, and they could be considered two of the factors related to autistic-like behaviors development.

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Section: Discussionmentioning

confidence: 99%

The autistic-like behaviors development during weaning and sexual maturation in VPA-induced autistic-like rats is accompanied by gut microbiota dysbiosis

Kong

Tian

Zhao

et al. 2021

PeerJ

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“…For example, the unconjugated homovanillic acid, which was the most increased metabolite in the control group, is the final product of dopamine metabolism (Bacopoulos et al, 1978). Wang et al (2020) reported that children with autism spectrum disorders had decreased homovanillic acid levels, which increased after treatment. Another distinct metabolite was sinapic acid, which is associated with the nutritional and biological functions of honey (Zhao et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Effects of Dietary Alteration on the Gut Microbiome and Metabolome of the Rescued Bengal Slow Loris

Zhang

et al. 2021

Front. Microbiol.

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Bengal slow lorises (Nycticebus bengalensis) are threatened by illegal trade. Subsequently, numerous wild-born individuals are rescued and transferred to rescue centers. Metabonomic analysis of intestinal microbiomes has increasingly played a vital role in evaluating the effects of dietary alteration on the captive status of endangered non-human primates. A synthetic analysis was done to test the differences in gut microbes and fecal metabolites between two dietary groups of Bengal slow lorises across 8 weeks. Dietary interventions led to intra-group convergence and inter-group variation in the composition of intestinal flora, metabolites, and short-chain fatty acids (SCFAs). The control diet, consisting of gums and honey, significantly increased the abundance of some potential probiotics, such as Bifidobacterium and Roseburia, and the concentration of some anti-disease related metabolites. The decrease in some amino acid metabolites in the original group fed without gums was attributed to poor body condition. Some distinct SCFAs found in the control group indicated the dietary alteration herein was fat-restricted but fiber deficient. Cognizant of this, plant exudates and fiber-enriched food supplies should be considered an optimal approach for dietary improvement of the confiscated and captive Bengal slow lorises.

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“…The presence of SCFAs was altered in ASD individuals; acetic and butyrate levels decreased while valeric acid was increased in the ASD group [ 134 ]. A recent study compared fecal SCFA levels between an ASD cohort ( n = 26) and healthy control ( n = 24) and found significantly reduced levels of acetate, propionate and butyrate in ASD individuals [ 135 ].…”

Section: Microbial Metabolite In Autism Spectrum Disorder and Attentimentioning

confidence: 99%

Gut instincts: vitamin D/vitamin D receptor and microbiome in neurodevelopment disorders

2020

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The gut microbiome regulates a relationship with the brain known as the gut–microbiota–brain (GMB) axis. This interaction is influenced by immune cells, microbial metabolites and neurotransmitters. Recent findings show gut dysbiosis is prevalent in autism spectrum disorder (ASD) as well as attention deficit hyperactivity disorder (ADHD). There are previously established negative correlations among vitamin D, vitamin D receptor (VDR) levels and severity of ASD as well as ADHD. Both vitamin D and VDR are known to regulate homeostasis in the brain and the intestinal microbiome. This review summarizes the growing relationship between vitamin D/VDR signalling and the GMB axis in ASD and ADHD. We focus on current publications and summarize the progress of GMB in neurodevelopmental disorders, describe effects and mechanisms of vitamin D/VDR in regulating the microbiome and synoptically highlight the potential applications of targeting vitamin D/VDR signalling in neurodevelopment disorders.

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Probiotics and fructo-oligosaccharide intervention modulate the microbiota-gut brain axis to improve autism spectrum reducing also the hyper-serotonergic state and the dopamine metabolism disorder

Cited by 175 publications

References 60 publications

The autistic-like behaviors development during weaning and sexual maturation in VPA-induced autistic-like rats is accompanied by gut microbiota dysbiosis

The autistic-like behaviors development during weaning and sexual maturation in VPA-induced autistic-like rats is accompanied by gut microbiota dysbiosis

Effects of Dietary Alteration on the Gut Microbiome and Metabolome of the Rescued Bengal Slow Loris

Gut instincts: vitamin D/vitamin D receptor and microbiome in neurodevelopment disorders

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