Probiotics: an Antibiotic Replacement Strategy for Healthy Broilers and Productive Rearing

Neveling, Deon P.; Dicks, Leon M. T.

doi:10.1007/s12602-020-09640-z

Cited by 74 publications

(61 citation statements)

References 143 publications

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“…It is critical to develop reliable methods to control heat stress. Probiotics, as a gut health-supporting additive, have been proposed as alternatives to antibiotics in broiler production [ 35 ].…”

Section: Heat Tolerance and Heat Stress In Commercial Broilersmentioning

confidence: 99%

“…The modulation of aberrant gut microbiota into a healthy state has become a critical objective for the poultry industry. In the past decade, numerous pieces of evidence have suggested that probiotics can be used as antibiotic replacements in poultry production [ 34 , 35 , 36 ]. Generally, probiotics confer a health benefit to chickens due to their positive effects on microbiota composition (restoring microbial homeostasis), mucosal barrier integrity (reducing gut permeability), and immune response (reducing inflammation).…”

Section: Introductionmentioning

confidence: 99%

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Bacillus subtilis-Based Probiotic Improves Skeletal Health and Immunity in Broiler Chickens Exposed to Heat Stress

Jiang

Yan

et al. 2021

Animals

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The elevation of ambient temperature beyond the thermoneutral zone leads to heat stress, which is a growing health and welfare issue for homeothermic animals aiming to maintain relatively constant reproducibility and survivability. Particularly, global warming over the past decades has resulted in more hot days with more intense, frequent, and long-lasting heat waves, resulting in a global surge in animals suffering from heat stress. Heat stress causes pathophysiological changes in animals, increasing stress sensitivity and immunosuppression, consequently leading to increased intestinal permeability (leaky gut) and related neuroinflammation. Probiotics, as well as prebiotics and synbiotics, have been used to prevent or reduce stress-induced negative effects on physiological and behavioral homeostasis in humans and various animals. The current data indicate dietary supplementation with a Bacillus subtilis-based probiotic has similar functions in poultry. This review highlights the recent findings on the effects of the probiotic Bacillus subtilis on skeletal health of broiler chickens exposed to heat stress. It provides insights to aid in the development of practical strategies for improving health and performance in poultry.

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Section: Heat Tolerance and Heat Stress In Commercial Broilersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bacillus subtilis-Based Probiotic Improves Skeletal Health and Immunity in Broiler Chickens Exposed to Heat Stress

Jiang

Yan

et al. 2021

Animals

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“…Beyond that, the number of Campylobacter jejuni and Salmonella enteritidis in the gastrointestinal tract of broilers were dropped with Lactobacillus salivarius supplementation. By the way, the level of serum lysozyme was elevated [33]. We found that the relative abundance of Lactobacillus salivarius in the ileal chyme was heightened in the 500 SS group.…”

Section: The Effect Of Ss On the Intestinal Micro Ora And Immune Function Of Laying Hensmentioning

confidence: 73%

Soy Saponin Improves Egg-Laying Performance and Immune Function of Laying Hens

Zhao

Yan

et al. 2021

Preprint

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Background It is of great significance to clarify the role of biologically active ingredients in soybean meal to solve the shortage of soybean meal resources. The objective of this experiment was to design a low soybean meal basal diet and measure the effects of dietary soya saponin (SS) on egg-laying performance and immune function. Results Results showed that egg production rate, feed conversion ratio (FCR), and eggshell quality tended to be improved in the 50 SS groups. Besides, peripheral blood LPS stimulation index and proportion of B lymphocytes ratio at 5th week were increased. Serum follicle stimulating hormone and Interleukin-4 (IL-4) levels were significantly elevated at 10th week in the 50 SS groups. We also found that mRNA levels of follicle stimulating hormone receptor (FSHR) in ovarian, nuclear transcription factor kappa B (NF-κB), Interleukin-12 (IL-12), Transforming growth factor (TGF-β) and Interferon γ (IFN-γ) in spleen were up-regulated at the end of the trial. Beyond that, the relative abundance of Proteobacteria in the ileal flora was dropped, and the relative abundances of Lactobacillus, Romboutsia and Lactobacillus delbrueckii were elevated in the 50 SS group. Similar to the above were that at the end of the 5th week, there are same biological effects on laying hens about 50 and 500 mg/Kg SS. While at the end of the trial, the blood levels of alanine aminotransferase, alkaline phosphatase, IFN-γ, and the ratio of IFN-γ to IL-4 were significantly increased in the 500 SS group. What’s more, the gene mRNA levels of NF-κB, IL-12, IFN-γ, Interleukin-1β (IL-1β), and the ratio of IFN-γ to IL-4 about spleen were up-regulated in the 500 SS group. The mRNA levels of genes such as the gonadotropin releasing hormone 1 (GnRH1) in Hypothalamus, the estrogen related receptor (ERR) in ovaries were down-regulated with 500 mg/kg SS supplementation. Conclustions: The egg production performance was improved by dietary supplementation with 50 mg/kg SS via stimulating ovaries development, increasing ovarian FSHR transcription level and serum estrogen level. The intestinal microflora was regulated, and the immune function of laying hens also was improved with 50 mg/kg SS supplementation. Unexpectedly, the immune homeostasis of the laying hens tilted towards the pro-inflammatory direction with 500 mg/kg SS supplementation. It resulted in a negative impact on the laying performance of laying hens and physiological functions of the liver.

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“…This genus was one of the probiotics for humans and animals, which was of great signi cance to intestinal health. Some of the probiotics could increase the nutritional value of feed and were highly related to the animal growth performance, as well as the best alternatives to replacing antibiotics in the feed industry (Neveling and Dicks 2020). The probiotic Lactobacillus species might promote the maturation of the intestinal microbiota and enhancement of intestinal immunity against certain pathogens (Gao et al 2017;Hardy et al 2013).…”

Section: Discussionmentioning

confidence: 99%

Dietary Purslane (Portulaca Oleracea L.) Promotes the Growth Performance of Broilers by Modulation of Gut Microbiota

Huang

Liu

Ye³

et al. 2020

Preprint

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Purslane is a widespread wild vegetable with both medicinal and edible properties. It is highly appreciated for its high nutritional value and is also considered as a high-quality feed resource for livestock and poultry. In this study, Sanhuang broilers were used to investigate the effect of feeding purslane diets on the growth performance in broilers and their gut microbiota. A total of 48 birds with good growth and uniform weight were selected and randomly allocated to four treatment groups A (control), B, C and D. Dietary treatments were fed with basal diet without purslane and diets containing 1%, 2% and 3% purslane. The 16S rDNA was amplified by PCR and sequenced using the Illumina HiSeq platform to analyze the composition and diversity of gut microbiota in the four sets of samples. The results showed that dietary inclusion of 2% and 3% purslane could significantly improve the growth performance and reduce the feed conversion ratio. Microbial diversity analysis indicated that the composition of gut microbiota of Sanhuang broilers mainly included Gallibacterium, Bacteroides and Escherichia-Shigella, etc. As the content of purslane was increased, the abundance of Lactobacillus increased significantly, and Escherichia-Shigella decreased. LEfSe analysis revealed that Bacteroides_caecigallinarum, Lachnospiraceae, Lactobacillales and Firmicutes had significant differences compared with the control group. PICRUSt analysis revealed bacteria mainly enriched in carbohydrate metabolism pathway due to the additon of purslane in the diet. These results suggest that the addition of purslane to feed could increase the abundance of Lactobacillus in intestine, modulate the environment of gut microbiota and promote the metabolism of carbohydrates to improve its growth performance. This study indicates that the effect of purslane on the growth-promoting performance of broilers might depend on its modulation on gut microbiota, so as to provide a certain scientific basis for the application of purslane in the feed industry.

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Probiotics: an Antibiotic Replacement Strategy for Healthy Broilers and Productive Rearing

Cited by 74 publications

References 143 publications

Bacillus subtilis-Based Probiotic Improves Skeletal Health and Immunity in Broiler Chickens Exposed to Heat Stress

Bacillus subtilis-Based Probiotic Improves Skeletal Health and Immunity in Broiler Chickens Exposed to Heat Stress

Soy Saponin Improves Egg-Laying Performance and Immune Function of Laying Hens

Dietary Purslane (Portulaca Oleracea L.) Promotes the Growth Performance of Broilers by Modulation of Gut Microbiota

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