Abstract:Objective: To observe the changes of depression-like behavior in SD rats
induced by maternal separation (MS) stress and to explore the effects of
probiotics on antidepressant-like behavior and cAMP/CREB signaling
pathway. Methods: Newborn SD rats were selected as experimental subjects
and divided into MS+NS group, CON+NS group, MS+P group and CON+P group
using random number table method, 12 rats in each group. At PND 22-49,
the MS+P and CON+P groups were given 1×109 CFU (0.1 ml) of probiotic
colonies by gavage… Show more
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