Probiotics: A novel approach in the management of food allergy☆☆☆★★★

Majamaa, Heli; Isolauri, Erika

doi:10.1016/s0091-6749(97)70093-9

Cited by 807 publications

(574 citation statements)

References 37 publications

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“…Both modes of administration have previously proved to be equally effective colonizers. 23 Written informed consent was obtained from the children's parents and the study design was approved by the Ethics Committee of the Hospital District of Southwest Finland.…”

Section: Subjects and Study Designmentioning

confidence: 99%

The impact of perinatal probiotic intervention on the development of overweight and obesity: follow-up study from birth to 10 years

et al. 2010

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Background: The achievements in combating the increasing trend of overweight and obesity have thus far been inadequate. The recently discovered instrumental role of the gut microbiota in host metabolism may offer a novel target in the prevention and management of obesity. Objective: To evaluate the impact of perinatal probiotic intervention on childhood growth patterns and the development of overweight during a 10-year follow-up. Patients and methods: Altogether 159 women were randomized and double-blinded to receive probiotics (1 Â 10 10 colonyforming units of Lactobacillus rhamnosus GG, ATCC 53103) or placebo 4 weeks before expected delivery; the intervention extending for 6 months postnatally. Anthropometric measurements of the children were taken at the ages of 3, 6, 12 and 24 months and at 4, 7 and 10 years in 113 (72%) children. Results: The excessive weight gain was detected to be two-parted; the initial phase of excessive weight gain initiating during fetal period and continuing until 24-48 months of age and a second phase of excessive weight gain starting after the age of 24-48 months. The perinatal probiotic intervention appeared to moderate the initial phase of excessive weight gain, especially among children who later became overweight, but not the second phase of excessive weight gain, the impact being most pronounced at the age of 4 years (P ¼ 0.063, analysis of variance for repeated measures). The effect of intervention was also shown as a tendency to reduce the birth-weight-adjusted mean body mass index at the age of 4 years (P ¼ 0.080, analysis of covariance). Conclusions: Early gut microbiota modulation with probiotics may modify the growth pattern of the child by restraining excessive weight gain during the first years of life. This novel observation calls for further epidemiological and clinical trials, with precise data on early growth patterns and on confounding factors influencing weight development.

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Section: Subjects and Study Designmentioning

confidence: 99%

The impact of perinatal probiotic intervention on the development of overweight and obesity: follow-up study from birth to 10 years

et al. 2010

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“…In one recently published study from Finland, infants with milk allergy and atopic dermatitis had milder symptoms and fewer markers of intestinal in¯ammation if their milk formula was forti®ed with lactobacilli (74).…”

Section: The Lifestyle Factors Which Have Been Proposed So Farmentioning

confidence: 99%

What drives the allergic march?

Wahn

2000

Allergy

131

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“…Majamaa & Isolauri (1997) have studied the effects of LGG supplementation for infants with atopic eczema and have found a reduction in the extent and intensity of atopic dermatitis. Several other studies have shown the potential of probiotics in the management and prevention of atopic disease, including the use of probiotics by pregnant mothers being suggested to confer protection to the unborn infant (Isolauri et al 2000;Kalliomäki et al 2003).…”

Section: Atopic Diseases and Food Allergymentioning

confidence: 99%

Probiotics and prebiotics in infant nutrition

2007

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The human colonic microflora has a central role in health and disease, being unique in its complexity and range of functions. As such, dietary modulation is important for improved gut health, especially during the highly-sensitive stage of infancy. Diet can affect the composition of the gut microflora through the availability of different substrates for bacterial fermentation. Differences in gut microflora composition and incidence of infection exist between breast-fed and formula-fed infants, with the former thought to have improved protection. Historically, this improvement has been believed to be a result of the higher presence of reportedly-beneficial genera such as the bifidobacteria. As such, functional food ingredients such as prebiotics and probiotics could effect a beneficial modification in the composition and activities of gut microflora of infants by increasing positive flora components. The prebiotic approach aims to increase resident bacteria that are considered to be beneficial for human health, e.g. bifidobacteria and lactobacilli, while probiotics advocates the use of the live micro-organisms themselves in the diet. Both approaches have found their way into infant formula feeds and aim to more closely simulate the gut microbiota composition seen during breast-feeding.

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Probiotics: A novel approach in the management of food allergy☆☆☆★★★

Cited by 807 publications

References 37 publications

The impact of perinatal probiotic intervention on the development of overweight and obesity: follow-up study from birth to 10 years

The impact of perinatal probiotic intervention on the development of overweight and obesity: follow-up study from birth to 10 years

What drives the allergic march?

Probiotics and prebiotics in infant nutrition

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