Probiotics: A new way to fight bacterial pulmonary infections?

Alexandre, Youenn; Blay, Gwenaëlle Le; Boisramé, Sylvie; Gall, Florence Le; Héry-Arnaud, Geneviève; Gouriou, S.; Vallet, Sophie; Berre, Rozenn Le

doi:10.1016/j.medmal.2013.05.001

Cited by 56 publications

(53 citation statements)

References 53 publications

(67 reference statements)

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“…For example, microcin-producing E. coli could inhibit the growth of Salmonella in vitro , but the results in vivo were not satisfactory (Frana et al, 2004). Contradictory results with very heterogeneous studies are reported on the treatment and the prophylaxis of upper respiratory tract infections (Alexandre et al, 2014). Furthermore, probiotics have adverse effect on the normal gut flora.…”

Section: Pro- Pre- and Synbioticsmentioning

confidence: 99%

Antibiotic alternatives: the substitution of antibiotics in animal husbandry?

Cheng¹,

Hao²,

Xie³

et al. 2014

Front. Microbiol.

499

332

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It is a common practice for decades to use of sub-therapeutic dose of antibiotics in food-animal feeds to prevent animals from diseases and to improve production performance in modern animal husbandry. In the meantime, concerns over the increasing emergence of antibiotic-resistant bacteria due to the unreasonable use of antibiotics and an appearance of less novelty antibiotics have prompted efforts to develop so-called alternatives to antibiotics. Whether or not the alternatives could really replace antibiotics remains a controversial issue. This review summarizes recent development and perspectives of alternatives to antibiotics. The mechanism of actions, applications, and prospectives of the alternatives such as immunity modulating agents, bacteriophages and their lysins, antimicrobial peptides, pro-, pre-, and synbiotics, plant extracts, inhibitors targeting pathogenicity (bacterial quorum sensing, biofilm, and virulence), and feeding enzymes are thoroughly discussed. Lastly, the feasibility of alternatives to antibiotics is deeply analyzed. It is hard to conclude that the alternatives might substitute antibiotics in veterinary medicine in the foreseeable future. At the present time, prudent use of antibiotics and the establishment of scientific monitoring systems are the best and fastest way to limit the adverse effects of the abuse of antibiotics and to ensure the safety of animal-derived food and environment.

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Section: Pro- Pre- and Synbioticsmentioning

confidence: 99%

Antibiotic alternatives: the substitution of antibiotics in animal husbandry?

Cheng¹,

Hao²,

Xie³

et al. 2014

Front. Microbiol.

499

332

View full text Add to dashboard Cite

show abstract

“…Scientific data has A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT 15 reported that MCP may exert similar processes in the respiratory tract as in the digestive tract [43]. MCP has also been hypothesized to decrease the colonization of pathogenic bacteria at the oropharyngeal and gastric level in mechanical ventilated patients with ability to modulate the immune system through its effects on, mucosa-associated lymphoid tissue (MALT), bronchus-associated lymphoid tissue (BALT) and gut-associated lymphoid tissue (GALT) [43]. This may indicate the correlation between return of gut function and shorter mechanical ventilation day.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Microbial cell preparation in enteral feeding in critically ill patients: A randomized, double-blind, placebo-controlled clinical trial

Malik

Rajandram

Tah

et al. 2016

Journal of Critical Care

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“…Microbial constituents of the above tracts were the same as those found in the upper respiratory tracts, whereas the bacterial concentration in lung is in much fewer levels. It is suggested that bacteria in alveolar could come from the upper respiratory tracts when considering similar bacterial constituents in alveolar and lung (15). It was also reported that the pulmonary microbiota in patients showing pneumonia (16) and bronchitis (17) was complex in microbial compositions.…”

Section: -1) Microbial Constituents and Diseases In Respiratory Tractmentioning

confidence: 99%

“…In [15]. In order to demonstrate the protective effects by probiotics on respiratory tract, the development of well organized and randomized double blind clinical trials is considered mandatory.…”

Section: -2) Probiotics Action On Epithelium Barrier Functionmentioning

confidence: 99%

Probiotics Used for Respiratory Diseases

Shin

Kim

2015

J Bacteriol Virol

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Continuous increase of bacterial resistance to antibiotics causes many problems such as the advent of resistance to pathogenic bacteria, difficulty of microbial disease treatments, environmental pollution and others. It is inevitable to find potential substitutes for antibiotics in order to solve the above mentioned problems. Recently many literatures have shown that probiotics could be applied to the treatment or amelioration of respiratory diseases in addition to intensively studied gut related diseases. Target diseases for collecting data and analysis of the efficacies were chosen because viral respiratory infections are the most common diseases in humans. They were mainly viral diseases like common colds, pneumonia in addition to allergies and asthma. Papers on clinical efficacies, safety risks and mechanisms of microbial action of respiratory diseases were secured through known information sites and analyzed for their exact evaluations. The present analysis of research results on probiotics efficacies for respiratory diseases showed discrepancies in efficacies. On the whole, half to one third of papers reviewed only showed certain level of efficacies against respiratory viral diseases. It is very difficult to compare the results directly because the studies varied highly in study design, outcome measures, probiotics, dose, and matrices used. However, the results obtained so far show the potential applications of probiotics to the prevention or amelioration of the diseases. Conclusively, further well organized studies using randomized, double-blind, placebo-controlled clinical trials are needed to elucidate the realities of probiotics on respiratory related diseases and to obtain more definite efficacy results.

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Probiotics: A new way to fight bacterial pulmonary infections?

Cited by 56 publications

References 53 publications

Antibiotic alternatives: the substitution of antibiotics in animal husbandry?

Antibiotic alternatives: the substitution of antibiotics in animal husbandry?

Microbial cell preparation in enteral feeding in critically ill patients: A randomized, double-blind, placebo-controlled clinical trial

Probiotics Used for Respiratory Diseases

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