Probiotic treatment restores normal developmental trajectories of fear memory retention in maternally separated infant rats

Peng, Hsuan Hui; Tsai, Tsung-Chih; Huang, Wan Yu; Wu, Hsiang Ling; Hsu, Kuei Sen

doi:10.1016/j.neuropharm.2019.04.026

Cited by 29 publications

(14 citation statements)

References 53 publications

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“…for 5 weeks. In rodent studies, however, supplementation of Lactobacillus rhamnosus and Lactobacillus helveticus [63,64], Bifidobacterium infantis [65] restored the fear responses in maternal-separation-stressed infant rats by reversing the stress effects on neural circuits. Although the mechanisms underlying the dietary synbiotic supplement improving the fear responses of broilers were not examined in this study, they may be attributed to its functions in producing neuroactive substances affecting brain neural signaling via the enteric nervous system, the vagal afferents, and/or the bloodstream [66][67][68].…”

Section: Discussionmentioning

confidence: 95%

Effect of a Synbiotic Supplement on Fear Response and Memory Assessment of Broiler Chickens Subjected to Heat Stress

Mohammed

Mahmoud

Murugesan³

et al. 2021

Animals

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The aim of this study was to evaluate the effect of a synbiotic containing a probiotic (Enterococcus faecium, Pediococcus acidilactici, Bifidobacterium animalis, and Lactobacillus reuteri) and a prebiotic (fructooligosaccharides) on fear response, memory assessment, and selected stress indicators in broilers subjected to heat stress. A total of 360 1-day-old Ross 708 chicks were evenly divided among three treatments: a basal diet mixed with a synbiotic at 0 (G-C), 0.5 (G-0.5X), and 1.0 (G-1.0X) g/kg. After 15 d, the broilers were exposed to 32 °C for 9 h daily until 42 d. The object memory test was conducted at 15 day; touch, novel object, and isolation tests were conducted at 35 day; tonic immobility (TI) took place at 41 day. At 42 day, plasma corticosterone and tryptophan concentrations and heterophile/lymphocyte (H/L) ratios were measured. Compared to controls, synbiotic-fed broilers, regardless of concentration, had a shorter latency to make the first vocalization, with higher vocalization rates during the isolation test (p = 0.001). the G-1.0 group had the lowest H/L ratio (p = 0.001), but higher plasma tryptophan concentrations and a greater number of birds could reach the observer during the touch test (p = 0.001 and 0.043, respectively). The current results indicate that the synbiotic can be used as a growth promoter to reduce the fear response and stress state of heat-stressed broilers.

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Section: Discussionmentioning

confidence: 95%

Effect of a Synbiotic Supplement on Fear Response and Memory Assessment of Broiler Chickens Subjected to Heat Stress

Mohammed

Mahmoud

Murugesan³

et al. 2021

Animals

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“…HPA axis response to acute stress was attenuated by Lactobacillus farciminis (Ait-Belgnaoui et al, 2018). Lactobacillus rhamnosus and Lactobacillus helveticus influence brain-derived neurotrophic factor (BDNF) levels in basolateral nucleus of amygdala exerting an anxiolytic effect (Peng et al, 2019). Hippocampal c-Fos expression is modulated by L. rhamnosus and L. helveticus (Smith et al, 2014).…”

Section: Probiotic Challengementioning

confidence: 99%

Mast Cells in Gut and Brain and Their Potential Role as an Emerging Therapeutic Target for Neural Diseases

Traina

2019

Front. Cell. Neurosci.

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The mast cells (MCs) are the leader cells of inflammation. They are well known for their involvement on allergic reactions through degranulation and release of vasoactive, inflammatory, and nociceptive mediators. Upon encountering potential danger signal, MCs are true sensors of the environment, the first to respond in rapid and selective manner. The MC activates the algic response and modulates the evolution of nociceptive pain, typical of acute inflammation, to neuropathic pain, typical not only of chronic inflammation but also of the dysregulation of the pain system. Yet, MC may contribute to modulate intensity of the associated depressive and anxiogenic component on the neuronal and microglial biological front. Chronic inflammation is a common mediator of these co-morbidities. In parallel to the removal of the etiological factors of tissue damage, the modulation of MC hyperactivity and the reduction of the release of inflammatory factors may constitute a new frontier of pharmacological intervention aimed at preventing the chronicity of inflammation, the evolution of pain, and also the worsening of the depression and anxiogenic state associated with it. So, identifying specific molecules able to modify MC activity may be an important therapeutic tool. Various preclinical evidences suggest that the intestinal microbiota contributes substantially to mood and behavioral disorders. In humans, conditions of the microbiota have been linked to stress, anxiety, depression, and pain. MC is likely the crucial neuroimmune connecting between these components. In this review, the involvement of MCs in pain, stress, and depression is reviewed. We focus on the MC as target that may be mediating stress and mood disorders via microbiota–gut–brain axis.

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“…In order to study the effects of probiotics on stress, researchers induced early life stress on infant rats and caused early expressions of adult-like fear memory retention. Administration of a probiotic supplement, Lacidofil, not only prevented the transition to adult-like fear memory retention, but also decreased anxiety-like behavior and increased neurotrophic factor protein levels in the basolateral nucleus of the amygdala [53]. This suggests a potential therapeutic effect that may occur for children who experience similar early life stress.…”

Section: Stress Anxiety and Depressionmentioning

confidence: 87%

The bioactive compounds of probiotic foods/supplements and their application in managing mental disorders

Martirosyan¹,

Leem

2019

Bioactive Compounds in Health and Disease

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Background: Probiotics have recently become popular among all generations, ranging from children to the elderly. They are living microorganisms known to improve gut flora by establishing and maintaining gut health via molecular mechanisms that involve various bioactive compounds produced and released throughout the body, which may cause a bacteria-host interaction. These bioactive compounds of probiotics may be bacteria or other compounds that are associated with various neurotransmitters, which produce different actions on the body. Changes in gut microbiota composition have been associated with various diseases, including mental disorders such as Alzheimer’s/dementia, Parkinson’s, schizophrenia, stress, anxiety, and depression. Clinical reviews and studies on both animals and humans have given mixed results regarding the efficacy of probiotic foods and supplements in managing mental disorders. In our review, we advocate for probiotic foods to be functional foods, but we are unable to accept probiotics as an effective treatment for the management of mental disorders due to indeterminate evidence. Keywords: Probiotics, bioactive compounds, mental disorders, Alzheimer’s disease, dementia, Parkinson’s, schizophrenia, stress, anxiety, and depression

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Probiotic treatment restores normal developmental trajectories of fear memory retention in maternally separated infant rats

Cited by 29 publications

References 53 publications

Effect of a Synbiotic Supplement on Fear Response and Memory Assessment of Broiler Chickens Subjected to Heat Stress

Effect of a Synbiotic Supplement on Fear Response and Memory Assessment of Broiler Chickens Subjected to Heat Stress

Mast Cells in Gut and Brain and Their Potential Role as an Emerging Therapeutic Target for Neural Diseases

The bioactive compounds of probiotic foods/supplements and their application in managing mental disorders

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