Probiotic treatment reduces depressive-like behaviour in rats independently of diet

Abildgaard, Anders; Elfving, Betina; Hokland, Marianne; Wegener, Gregers; Lund, Sten

doi:10.1016/j.psyneuen.2017.02.014

Cited by 161 publications

(92 citation statements)

References 51 publications

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“…Per os administration of a probiotic mixture containing 4 strains of lactobacilli, 3 strains of bifidobacteria, and 1 strain of Streptococcus thermophilus to infants with colic reduced clinical symptoms, while increasing fecal levels of alanine, leucine, isoleucine, acetate, and pyruvate and decreasing the levels of uracil and propylene glycol, compared with placebo controls (49). Finally, a similar relationship between reduction of disease scores and alterations in metabolic profiles induced by administration of bacterial probiotics has been reported in animal models of human diseases, including fecal metabolites in mice with chemical-induced colits (50) and serum metabolites in rats with depression-related behavioral changes (51).…”

Section: Discussionsupporting

confidence: 52%

Dietary Supplementation With Bacillus subtilis Direct-Fed Microbials Alters Chicken Intestinal Metabolite Levels

Park

Zimmerman²,

Smith³

et al. 2020

Front. Vet. Sci.

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Direct-fed microbials (DFMs) are dietary supplements containing live microorganisms which confer a performance and health benefit to the host, but the mechanisms are unclear. Here, a metabolomics approach was used to identify changes in intestinal metabolite levels in chickens fed an unsupplemented diet or a diet supplemented with B. subtilis strain 1781 or strain 747. Body weight gains of chickens fed the B. subtilis-supplemented diets were increased up to 5.6% in the B. subtilis 1781 group and 7.6% in the B. subtilis 747 group compared with chickens fed the unsupplemented diet. Compared with unsupplemented controls, the levels of 83 metabolites were altered (p < 0.05) (25 increased, 58 decreased) in chickens given the B. subtilis 1781-supplemented diet, while 50 were altered (p < 0.05) (12 increased, 38 decreased) with the B. subtilis 747-supplemented diet. Twenty-two metabolites were altered (p < 0.05) (18 increased, 4 decreased) in the B. subtilis 1781 vs. B. subtilis 747 groups. A random forest analysis of the B. subtilis 1781 vs. control groups gave a predictive accuracy of 87.5%, while that of the B. subtilis 747 vs. control groups was 62.5%. A random forest analysis of the B. subtilis 1781 vs. B. subtilis 747 groups gave a predictive accuracy of 75.0%. Changes in the levels of these intestinal biochemicals provided a distinctive biochemical signature unique to each B. subtilis-supplemented group, and were characterized by alterations in the levels of dipeptides (alanylleucine, glutaminylleucine, phenylalanylalanine, valylglutamine), nucleosides (N1-methyladenosine, N6-methyladenosine, guanine, 2-deoxyguanosine), fatty acids (sebacate, valerylglycine, linoleoylcholine), and carbohydrates (fructose). These results provide the foundation for future studies to identify biochemicals that might be used to improve poultry growth performance in the absence of antibiotic growth promoters.

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Section: Discussionsupporting

confidence: 52%

Dietary Supplementation With Bacillus subtilis Direct-Fed Microbials Alters Chicken Intestinal Metabolite Levels

Park

Zimmerman²,

Smith³

et al. 2020

Front. Vet. Sci.

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“…MIA, which induces various behavioral phenotypes associated with autism in offspring, has been identified as a vital environmental risk factor for ASD (Choi et al, 2016;Estes & McAllister, 2016;Knuesel et al, 2014;Malkova et al, 2012), in spite of a few clinical epidemiologic studies reporting no association between MIA and ASD when looking at the total period of pregnancy (Atladottir et al, 2010). Considering the immunomodulatory and neuroprotective effects of probiotic bacteria (Abildgaard, Elfving, Hokland, Wegener, & Lund, 2017;Delcenserie et al, 2008;Keunen, van Elburg, van Bel, & Benders, 2015;Saez-Lara et al, 2015), oral probiotics may be useful as a means to decrease the incidence of ASD. Our present study supports this hypothesis by showing that the administration of oral probiotics during pregnancy prevented a series of MIA-induced ASD-relevant deficits, including impairments in social behavior, repetitive behavior, stereotyped behavior, depression-like behavior, and anxiety-like behavior.…”

Section: Discussionmentioning

confidence: 99%

Oral probiotic administration during pregnancy prevents autism‐related behaviors in offspring induced by maternal immune activation via anti‐inflammation in mice

et al. 2019

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Maternal immune activation (MIA) is associated with an increased risk for autism spectrum disorders (ASD) in offspring. Animal experiments have found that interleukin 6 (IL‐6) and IL‐17a are key cytokines in the induction of ASD by MIA. Moreover, probiotics were verified to inhibit the production of proinflammatory cytokines. Therefore, we investigated whether the administration of oral probiotics during pregnancy might protect the offspring that have suffered MIA from developing ASD. Probiotics were orally administered to pregnant mice with/without the simultaneous administration of Poly(I:C). We found that oral probiotics prevented the ASD‐like behaviors induced by MIA in offspring. Furthermore, oral probiotics prevented the MIA‐induced increases in the IL‐6 and IL‐17a levels in both maternal serum and fetal brains, parvalbumin positive (PV+) neuron loss, and the decrease in the γ‐aminobutyric acid levels in the prefrontal cortex of adult offspring. This work suggests that administering oral probiotics during pregnancy may help decrease the risk of ASD following MIA during pregnancy. Autism Res 2019, 12: 576–588. © 2019 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Interleukin 6 (IL‐6) and IL‐17a are key cytokines in the maternal immune activation (MIA)‐induced autism spectrum disorders (ASD). Based on emerging evidence that probiotics can inhibit the production of proinflammatory cytokines, we found that oral probiotics prevented MIA‐induced ASD‐like behaviors in offspring. This work suggested that oral probiotics during pregnancy may be an effective means for decreasing the incidence of ASD in offspring.

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“…Increased immobility is associated with a depressive‐like phenotype . The two‐day FST protocol included OF testing to assess locomotor activity, an important cofounder of the FST. On day one of the FST, 4 weeks after the SAB test, rats were acclimatised to the testing room (150 lx) 1 hour prior to testing.…”

Section: Methodsmentioning

confidence: 99%

BDNF^+/− rats exhibit depressive phenotype and altered expression of genes relevant in mood disorders

Martis

Wiborg

Holmes

et al. 2019

Genes Brain and Behavior

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Major depressive disorder (MDD) is a leading contributor to the global burden of disease. However, the causal relationship of risk factors, such as genetic predisposition or experience of augmented stress, remain unknown. Numerous studies in humans and rodents have implicated brain‐derived neurotrophic factor (BDNF) in MDD pathology, as a genetic risk factor and a factor regulated by stress. Until now, the majority of preclinical studies have employed genetically modified mice as their model of choice. However, mice display a limited behavioural repertoire and lack expression of circulating BDNF, which is present in rats and humans. Therefore, heterozygous BDNF (BDNF+/−) rats were tested for affective behaviours and accompanying expression of key genes associated with affective disorders in the brain. We found that BDNF+/− rats, which have reduced BDNF levels in brain and plasma, displayed symptoms of anhedonia, a core symptom of MDD, and anxiety‐like behaviour, but no behavioural despair or cognitive impairments. This was accompanied by changes in the expression of genes that are implicated in modulation of the stress response and affective disorders. Hence, glucocorticoid receptor, neuregulin 1 and disrupted‐in‐schizophrenia 1 gene expression were upregulated in the prefrontal cortex of BDFN+/− rats, whereas FK506 binding protein 5 levels were decreased in the hippocampus. We conclude that a reduction in BDNF levels alters expression of genes associated with affective disorders, which may contribute to the development of depressive‐like symptoms.

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Probiotic treatment reduces depressive-like behaviour in rats independently of diet

Cited by 161 publications

References 51 publications

Dietary Supplementation With Bacillus subtilis Direct-Fed Microbials Alters Chicken Intestinal Metabolite Levels

Dietary Supplementation With Bacillus subtilis Direct-Fed Microbials Alters Chicken Intestinal Metabolite Levels

Oral probiotic administration during pregnancy prevents autism‐related behaviors in offspring induced by maternal immune activation via anti‐inflammation in mice

BDNF^+/− rats exhibit depressive phenotype and altered expression of genes relevant in mood disorders

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Probiotic treatment reduces depressive-like behaviour in rats independently of diet

Cited by 161 publications

References 51 publications

Dietary Supplementation With Bacillus subtilis Direct-Fed Microbials Alters Chicken Intestinal Metabolite Levels

Dietary Supplementation With Bacillus subtilis Direct-Fed Microbials Alters Chicken Intestinal Metabolite Levels

Oral probiotic administration during pregnancy prevents autism‐related behaviors in offspring induced by maternal immune activation via anti‐inflammation in mice

BDNF+/− rats exhibit depressive phenotype and altered expression of genes relevant in mood disorders

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BDNF^+/− rats exhibit depressive phenotype and altered expression of genes relevant in mood disorders