Probiotic supplements for relieving stress in healthy participants

Abstract

Background: Psychological stress is a ubiquitous subjectively negative emotional experience, but excessive psychological stress has adverse effects on the happiness in our lives and physical and mental health, and may cause many health problems. Studies have found that probiotics have a certain role in alleviating negative emotions, reducing abnormal behaviors, improving cognitive function, and also showing the great potential of probiotics in relieving psychological stress. At present, many clinical trials have been carried out to intervene in populations with psychological stress with probiotic supplements, but there still lack of targeted systematic review and meta-analysis. Methods and analysis: The Cochrane Central Register of Controlled Trials, Embase, MEDLINE, Psycoinfo, Cumulative Index to Nursing and Allied Health Literature will be searched to obtain the eligible randomized controlled trials published up to March 1, 2019. Meanwhile, the references to relevant publications will also be reviewed to identify other studies, and will re-search before finial summary for analysis. EndNote X7 will be used as a document manager for duplicate checking and screening of literature. The risk of bias will be assessed and the date of included studies will be analyzed by Revman V5.3.5. Results: The primary outcome will be subjective stress level, general mild psychiatric symptoms of participants. The secondary outcome will be cortisol level and adverse effects likely to be related to treatment. Conclusion: The systematic review and meta-analysis will provide evidence to assess the efficacy and safety of probiotics in relieving psychological stress. PROSPERO registration number: PROSPERO CRD42019122930.

The role of probiotics and prebiotics in modulating of the gut-brain axis

“…Various prebiotics have enhanced the stress-protective microbial organism’s activity and growth. Therefore, prebiotics in the diet increases the bacterial species to produce lactic acid and butyrate (stress-protective microbial species) and maintain the host from the neurobiological, behavioral, and physiological effects of stress ( 23 , 60 ).…”

“…the decline of Bifidobacterium spp. in feces ( 23 ). In addition, it was found that Bifidobacterium longum 1714™ modulated resting neural activity, enhanced mental vitality, and attenuated mental fatigue which leads to neural response modulation during stress ( 61 ).…”

Probiotics in dairy farming: A holistic approach to animal nutrition

“…Moreover, the diversity of the gut microbiome has been shown to regulate cognitive behaviour by promoting the synthesis of essential neurotransmitters and neuropeptides in rodents (Desbonnet et al, 2015) [46] . Additionally, probiotics have been associated with restoring gut homeostasis, thereby reducing anxiety and alleviating stress levels in individuals (Scott et al, 2013; Zhang et al, 2019) [126,114] . Research into farm animals has shown that the gut microbiome has the potential to influence stress levels in dairy animals, mirroring findings in humans.…”

Cross-sectional study to assess the healthcare professionals’ knowledge, attitude and practices about probiotics use in Pakistan

“… 13 These complications can be treated and prevented by the use of probiotics. Moreover, probiotics are also beneficial in the management of health conditions other than GIT like urinary tract 14 and respiratory tract infections, 15 allergies, 16 obesity, 17 stress 18 and cardiovascular disorders. 19 …”