Probiotic supplementation reduces a biomarker for increased risk of liver cancer in young men from Southern China

Abstract

A probiotic supplement reduces the biologically effective dose of aflatoxin exposure and may thereby offer an effective dietary approach to decrease the risk of liver cancer.

Dairy Propionibacteria: Less Conventional Probiotics to Improve the Human and Animal Health

“…Mycotoxins are also forage contaminants, which impair animal performances and health. Several probiotic bacteria, commonly used in food products, have been shown to bind Aflatoxin B1 and the toxins produced by Fusarium sp such as zearalenone, fumonisins B1 and B2 and trichothecenes, like deoxynivalenol (DON), nivalenol (NIV) and T-2 toxin (T-2) preventing their absorption in the gastrointestinal tracts of animals and humans [210][211][212][213][214].…”

“…The capacity of Propionibacterium freudenreichii strain JS used alone and combined with lactobacilli (L. rhamnosus GG or LC705) to remove mycotoxins has been studied by in vitro [210][211][212], ex vivo [211] and in vivo assays [213][214]. It has been determined that both viable and heat-killed forms of propionibacteria are able to remove efficiently aflatoxin B1, fumonisins and trichotecenes from liquid media.…”

“…On clinical trials it has been observed that the consumption of a probiotic preparation containing both P. freudenreichii JS and L. rhamnosus LC-705 reduced in a significant manner the levels AFB1 in fecal samples [213] and the concentration of urinary AFB-N7-guanine [214] of healthy volunteers during treatment and even after several days after probiotic consumption ceased. These results suggest that the probiotic bacteria used in these trials could block the intestinal absorption of aflatoxin B1…”

Lactobacillus rhamnosus GG Inhibits BID Dependent-Apoptosis in Human Hepatocellular Carcinoma Cells Exposed to Patulin

“…Administration of Lactobacillus rhamnosus LC705 in combination with Propionibacterium freudenreichii subsp. shermanii led to lower AFB-N7 during a five-week study (El-Nezami et al, 2006). Administration of probiotic homogenate significantly reduced ODC mRNA and activity as well as polyamine content and neoplastic proliferation in HGC-27 cancer cell line (Russo et al, 2007).…”

Probiotics and Liver Disease

“…43 Another interesting report from China evaluated a multistrain probiotic (Lactobacillus and Propionobacterium species) in healthy individuals and noted a decrease in urinary excretion of aflatoxin metabolite, suggesting that probiotics may reduce exposure to aflatoxin and may have a chemopreventive role in hepatocellular carcinoma. 44 Also, the use of synbiotics seems to decrease bacterial infections after liver transplantation. 45 In a recent randomized study, preoperative and postoperative use of a synbiotic preparation significantly reduced infectious complications after elective living-donor liver transplantation.…”