Probiotic supplementation for the first 6 months of life fails to reduce the risk of atopic dermatitis and increases the risk of allergen sensitization in high-risk children: A randomized controlled trial

Taylor, Angie; Dunstan, Janet; Prescott, Susan L.

doi:10.1016/j.jaci.2006.08.036

Cited by 479 publications

(364 citation statements)

References 27 publications

Supporting

Mentioning

333

Contrasting

Unclassified

Order By: Relevance

“…120 In contrast, ingestion of L. acidophilus LAVRI for the fi rst 6 months of life raised the rate of sensitization to a variety of food and inhalant allergens tested. 119 In addition, this and the recent LGG trial showed a signifi cantly greater frequency of wheezing or wheezing bronchitis in the probiotic compared with the placebo groups. 119,125 Wheezing in infancy may be a risk factor for developing asthma later.…”

Section: Probiotics In Allergic Diseasesmentioning

confidence: 68%

“…[119][120][121]124 In three of the trials, the rates of sensitization also did not differ signifi cantly between the probiotic and the placebo group. 121,124,125 Supplementation with L. reuteri ATCC 55730 lowered the incidence of skin prick reactivity in infants with mothers with allergies.…”

Section: Probiotics In Allergic Diseasesmentioning

confidence: 88%

“…All of these trials enrolled infants at high risk of developing allergy, usually defi ned as ≥1 family member having an allergic disease. In all studies except one, 119 the mothers received the supplement for the last weeks of pregnancy. After that, the study design becomes more variable, with the supplement being given to the lactating mother for varying periods, or to the infant directly until 6 months postnatally.…”

Section: Probiotics In Allergic Diseasesmentioning

confidence: 99%

See 2 more Smart Citations

Probiotics and immunity

et al. 2009

View full text Add to dashboard Cite

Probiotics are defi ned as live microorganisms that, when administered in adequate amounts, confer a health benefi t on the host, including the gastrointestinal tract. While this benefi cial effect was originally thought to stem from improvements in the intestinal microbial balance, there is now substantial evidence that probiotics can also provide benefi ts by modulating immune functions. In animal models, probiotic supplementation is able to provide protection from spontaneous and chemically induced colitis by downregulating infl ammatory cytokines or inducing regulatory mechanisms in a strain-specifi c manner. In animal models of allergen sensitization and murine models of asthma and allergic rhinitis, orally administered probiotics can straindependently decrease allergen-specifi c IgE production, in part by modulating systemic cytokine production. Certain probiotics have been shown to decrease airway hyperresponsiveness and infl ammation by inducing regulatory mechanisms. Promising results have been obtained with probiotics in the treatment of human infl ammatory diseases of the intestine and in the prevention and treatment of atopic eczema in neonates and infants. However, the fi ndings are too variable to allow fi rm conclusions as to the effectiveness of specifi c probiotics in these conditions.

show abstract

Section: Probiotics In Allergic Diseasesmentioning

confidence: 68%

Section: Probiotics In Allergic Diseasesmentioning

confidence: 88%

Section: Probiotics In Allergic Diseasesmentioning

confidence: 99%

See 1 more Smart Citation

Probiotics and immunity

et al. 2009

View full text Add to dashboard Cite

show abstract

“…However, these studies did attract criticisms regarding their favored design towards desired outcome and interpretation of the data (Matricardi 2002). In addition to this, some studies demonstrated that the probiotic supplementation has no significant impact on the symptoms associated with infantile AD (Brouwer et al 2006) and hence, increased the risk of allergen sensitization in children with a high-risk of atopic diseases (Taylor et al 2007). It could be potentially unsafe in people sensitive to cow's milk allergy (Moneret-Vautrin et al 2006;Lee et al 2007).…”

Section: Allergy To Milk Proteinsmentioning

confidence: 99%

Trends in dairy and non-dairy probiotic products - a review

2015

View full text Add to dashboard Cite

Health awareness has grown to a greater extent among consumers and they are looking for healthy probiotic counterparts. Keeping in this view, the present review focuses recent developments in dairy and non-dairy probiotic products. All over the world, dairy probiotics are being commercialized in many different forms. However, the allergy and lactose intolerance are the major set-backs to dairy probiotics. Whereas, flavor and refreshing nature are the major advantages of non-dairy drinks, especially fruit juices. Phenotypic and genotypic similarities between dairy and non-dairy probiotics along with the matrix dependency of cell viability and cell functionality are reviewed. The heterogeneous food matrices of non-dairy food carriers are the major constraints for the survival of the probiotics, while the probiotic strains from non-dairy sources are satisfactory. Technological and functional properties, besides the viability of the probiotics used in fermented products of non-dairy origin are extremely important to get a competitive advantage in the world market. The functional attributes of dairy and non-dairy probiotic products are further enhanced by adding prebiotics such as galacto-oligosaccharide, fructo-oligosaccharide and inulin.

show abstract

“…A genetic analysis of the composition of the intestinal microbial flora was performed on a subgroup of 45 patients, showing a high prevalence of probiotic flora in the gut and, in particular, the presence of numerous L. casei DN-114001 colonies in patients receiving the intervention as compared to the control group: gut colonization by probiotics persisted after 6 and 12 months in almost all subjects. Numerous studies have shown promising results on the effectiveness of probiotics in reducing the incidence of allergic reactions [77][78][79][80].…”

Section: Allergic and Atopic Diseases In Childrenmentioning

confidence: 99%

Probiotics and health: An evidence-based review

Aureli

Capurso

Castellazzi

et al. 2011

Pharmacological Research

227

128

View full text Add to dashboard Cite

a b s t r a c tThe intestinal microbiota is an ecosystem formed by a variety of ecological niches, made of several bacterial species and a very large amount of strains. The microbiota is in close contact with the intestinal mucosa or epithelial interface which is, after the respiratory area, the largest surface of the body, occupying approximately 250-400 m 2 . The physiological activities of the microbiota are manifold and are just being unraveled. Based on the observations of the multiple roles played by the microbiota in health and disease, the notion of modifying it with appropriate formulations, i.e. probiotics, is being tested in several settings.This review summarizes the current knowledge on probiotics and discusses both limitations and acquired evidence to support their use in preventive and therapeutic medicine.

show abstract

Probiotic supplementation for the first 6 months of life fails to reduce the risk of atopic dermatitis and increases the risk of allergen sensitization in high-risk children: A randomized controlled trial

Cited by 479 publications

References 27 publications

Probiotics and immunity

Probiotics and immunity

Trends in dairy and non-dairy probiotic products - a review

Probiotics and health: An evidence-based review

Contact Info

Product

Resources

About