Probiotic supplementation attenuates increases in body mass and fat mass during high‐fat diet in healthy young adults

Osterberg, Kristin L.; Boutagy, Nabil E.; McMillan, Ryan P.; Stevens, Joseph R.; Frisard, Madlyn I.; Kavanaugh, John; Davy, Brenda M.; Davy, Kevin P.; Hulver, Matthew W.

doi:10.1002/oby.21230

Cited by 72 publications

(76 citation statements)

References 40 publications

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“…and European-Americans. Among them, B. longum, the anti-obesity and weight loss effects of which had been indicated in both rats [45] and human studies [46], showed the strongest association in our study. Within the genus Bifidobacterium, we also found associations for another two species, B. scardovii and B. subtile, which had not been reported for antiobesity and weight loss in any literature.…”

Section: Discussionsupporting

confidence: 56%

Oral microbiome and obesity in a large study of low-income and African-American populations

Yang

Cai

Wang

et al. 2019

Journal of Oral Microbiology

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Few studies have evaluated the relationship of oral microbiome with obesity. We investigated the oral microbiome among 647 obese and 969 non-obese individuals from the Southern Community Cohort Study, through 16S rRNA gene sequencing in mouth rinse samples. We first investigated 16 taxa in two probiotic genera, Bifidobacterium and Lactobacillus . Among them, eight showed nominal associations with obesity ( P < 0.05). Especially, Bifidobacterium (odds ratio [OR] = 0.67, 95% confidence interval [CI]:0.54, 0.83) and Bifidobacterium longum (OR = 0.57, 95% CI: 0.45, 0.73) were significantly associated with decreased obesity prevalence with false-discovery rate (FDR)-corrected P of 0.01 and 5.41 × 10 −4 , respectively. Multiple other bacterial taxa were also significantly associated with obesity prevalence at FDR-corrected P < 0.05. Among them, five in Firmicutes and two respectively in Actinobacteria and Proteobacteria were significantly associated with increased obesity prevalence. Significant associations with decreased obesity prevalence were observed for two taxa respectively in Actinobacteria and Firmicutes . Most of these taxa were associated with body mass index at study enrollment and weight gain during adulthood. Also, most of these associations were observed in both European- and African-Americans. Our findings indicate that multiple oral bacterial taxa, including several probiotic taxa, were significantly associated with obesity.

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Section: Discussionsupporting

confidence: 56%

Oral microbiome and obesity in a large study of low-income and African-American populations

Yang

Cai

Wang

et al. 2019

Journal of Oral Microbiology

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“…Gut microbiota has been studied for decades in order to evaluate its impact on different aspects of human health and body composition [18–20], and recently, the role of probiotics with or without diet has been evaluated in terms of changing the overall health status [50, 51], body weight, body composition, and obesity [52, 53]. …”

Section: Discussionmentioning

confidence: 99%

Evidences of a New Psychobiotic Formulation on Body Composition and Anxiety

Colica

Avolio

Bollero

et al. 2017

Mediators of Inflammation

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Background Gut microbiota is implied in obesity, because of its ability to harvest energy from diet, and in the regulation of behavior. Given the link between gut microbiota, body composition, obesity, and anxiety, the aim of this study was to evaluate the effects of a new psychobiotic formulation. Methods Eligible patients were randomly divided into three groups: psychobiotics oral suspension group (POSG); dietary treatment group (DTG); combined treatment group (CTG). All subjects underwent body composition and psychological profile evaluation. Results Significant changes in body composition parameters in each group were relieved after all treatments. Hamilton anxiety rating scale (HAM-A) highlighted a significant reduction of the total score for all study population after treatments in POSG (p = 0.01) and CTG (p = 0.04). A reduction of HAM-A total score in anxious subjects in POSG or CTG and a significant reduction of positive subjects for HAM-A in POSG (p = 0.03) and in CDG (p = 0.01) were shown. Discussion Three-week intake of selected POS represents a good approach to solve problems related to obesity and behavior disorders. However, new clinical trials need to be performed on a larger population and for a longer period of treatment before definitive conclusions can be made. This trial is registered with NCT01890070.

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“…Interestingly, the probiotic yeast Saccharomyces boulardii Biocodex was shown to improve the metabolic profile of genetically obese and diabetic db/db mice. 38 Daily consumption of the yeast altered gut microbiota composition, including an increase in Bacteroidetes and decrease in Firmicutes, with a concurrent decrease in host adiposity and circulating inflammatory markers.…”

Section: Call Out: Prebiotics Can Alter the Gut Microfloramentioning

confidence: 99%

The Gut Microbiome and Its Role in Obesity

2016

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The human body is host to a vast number of microbes, including bacterial, fungal and protozoal microoganisms, which together constitute our microbiota. Evidence is emerging that the intestinal microbiome is intrinsically linked with overall health, including obesity risk. Obesity and obesity-related metabolic disorders are characterized by specific alterations in the composition and function of the human gut microbiome. Mechanistic studies have indicated that the gastrointestinal microbiota can influence both sides of the energy balance equation; namely, as a factor influencing energy utilization from the diet and as a factor that influences host genes that regulate energy expenditure and storage. Moreover, its composition is not fixed and can be influenced by several dietary components. This fact raises the attractive possibility that manipulating the gut microbiota could facilitate weight loss or prevent obesity in humans. Emerging as possible strategies for obesity prevention and/or treatment are targeting the microbiota, in order to restore or modulate its composition through the consumption of live bacteria (probiotics), nondigestible or limited digestible food constituents such as oligosaccharides (prebiotics), or both (synbiotics), or even fecal transplants.

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Probiotic supplementation attenuates increases in body mass and fat mass during high‐fat diet in healthy young adults

Cited by 72 publications

References 40 publications

Oral microbiome and obesity in a large study of low-income and African-American populations

Oral microbiome and obesity in a large study of low-income and African-American populations

Evidences of a New Psychobiotic Formulation on Body Composition and Anxiety

The Gut Microbiome and Its Role in Obesity

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