Probiotic Supplementation and Its Effect on Weight and Feed tolerance in Preterm Low Birth Weight Newborns: A Clinical Trial

Moni, Sadeka Choudhury; Mannan, MA; Dey, Sanjoy; Dey, Arjun Chandra; Saha, Dipanwita; Shahidullah, Mohammod

doi:10.3329/bjch.v39i2.31538

Cited by 3 publications

(10 citation statements)

References 19 publications

(23 reference statements)

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“…However, in our study we compared birth weight (P = 0.083) and weight at discharge (P = 0.196), that shows there were no significant differences in weight variation (P = 0.437) in each group. One other study also demonstrated similar results, that weight gain was not affected by probiotic supplementation (24). However results of a similar studies in preterm infants born at less than 34 weeks showed that the mean weight gain of newborns in probiotic group was significantly higher than control group (14,25).…”

Section: Discussionmentioning

confidence: 57%

Effect of Probiotics on Full Intestinal Feeding in Premature Infants: A Double Blind, Clinical Trial

Jalali¹,

shiri²,

Shirazi³

2020

Iran J Pediatr

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Background: Premature infants suffer from many problems due to the lack of evolution of the digestive system, and early onset of intestinal feeding prevents these complications. Probiotics have been used to prevent intestinal disorders in preterm infants due to their many benefits. Objectives: This study was conducted to measure the efficacy of probiotics on time to reach full intestinal feeds (120 cc/kg/day) in premature newborns. Methods: This study was double-blind randomized clinical trial. Preterm infants born at < 36 weeks and birth weight of 1000 – 2500 gr (n = 58) in 17th Shahrivar Hospital, Rasht, Iran, were randomly assigned into intervention group (oral administration of probiotics) and control group (with normal saline administration). Data were collected using a data form that includes demographic characteristics, time to full intestinal feeding, and the incidence of complications. Data were analyzed by SPSS version 21 using descriptive and analytical statistical tests. Results: The results of the study showed that the mean and standard deviation time to full intestinal feeding in the probiotic group was 5.7 ± 1.06 days, while in the placebo group was 6.72 ± 1.98 days, which was statistically significant (P = 0.002). There were no significant correlation between study variables and time to full intestinal feeding except mode of delivery (P = 0.029). Conclusions: Feeding with probiotics is recognized as an effective way to prevent adverse health outcomes in preterm infants. The present study showed that administration of probiotics reduced the time to full feeding. Therefore, it is an effective and inexpensive method to prevent intestinal disorders in newborns.

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Section: Discussionmentioning

confidence: 57%

Effect of Probiotics on Full Intestinal Feeding in Premature Infants: A Double Blind, Clinical Trial

Jalali¹,

shiri²,

Shirazi³

2020

Iran J Pediatr

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“…0.72 ± 0.04 cm/week; p = 0.67, Linear growth b : 0.89 ± 0.04 vs . 0.87 ± 0.04 cm/week; p = 0.17 Choudhury et al [ 43 ] 2015 Single centre Bangladesh GA b : 31.9 ± 1.32 vs . 32.04 ± 1.26; p = 0.76, BW: 1000 - <1800. p = NS n = 28/30 vs. 29/35; TS6 Probiotic (Eight viable strains mixture of Lactobacillus and Bifidobacterium (20 billion/2 gram) vs .…”

Section: Resultsmentioning

confidence: 99%

“…Twenty-two RCTs were single centre [ 35 , 36 , 39 , 40 , 42 , 43 , 45 , 46 , 48 , 49 , 51 , 53 – 58 , 60 – 64 , 67 , 68 ], while eight were multicentre RCTs [ 34 , 37 , 38 , 41 , 44 , 47 , 50 , 52 , 59 , 65 , 66 ]. Primary and secondary outcomes in the included studies varied (Supplementary Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…Single-strain probiotic was used in 21 RCTs: Bifidobacteria [ 36 , 44 , 46 , 47 , 56 , 57 , 60 , 62 , 65 ], Lactobacillus [ 34 , 35 , 37 , 38 , 45 , 53 – 55 , 61 , 63 , 64 , 67 ] and Saccharomyces [ 42 , 49 , 51 , 59 ]. Multi-strain probiotic was used in nine RCTs including one that used two Bifidobacterium strains from same genus [ 41 ], whereas eight used a combination of probiotic strains from different genera [ 39 , 40 , 43 , 48 , 50 , 52 , 58 , 66 , 68 ].…”

Section: Resultsmentioning

confidence: 99%

“…Four RCTs used only expressed breast milk (EBM) [ 43 , 45 , 63 , 68 ], while 4 used pasteurized donor human milk (PDHM) along with EBM [ 34 , 37 , 39 , 48 , 56 ]. Fourteen RCTs used a combination of EBM or PDHM with infant formula [ 36 , 40 , 41 , 44 , 46 , 47 , 49 – 51 , 54 , 58 , 60 – 62 , 64 – 67 ].…”

Section: Resultsmentioning

confidence: 99%

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Growth and neuro-developmental outcomes of probiotic supplemented preterm infants—a systematic review and meta-analysis

et al. 2023

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Gut dysbiosis is associated with sepsis and necrotizing enterocolitis in preterm infants, which can adversely affect long-term growth and neurodevelopment. We aimed to synthesise evidence for the effect of probiotic supplementation on growth and neurodevelopmental outcomes in preterm infants. MEDLINE, EMBASE, EMCARE, Cochrane CENTRAL, and grey literature were searched in February 2022. Only randomized controlled trials (RCTs) were included. Meta-analysis was performed using random effects model. Effect sizes were expressed as standardized mean difference (SMD), mean difference (MD) or risk ratio (RR) and their corresponding 95% confidence intervals (CI). Risk of Bias (ROB) was assessed using the ROB-2 tool. Certainty of Evidence (CoE) was summarized using GRADE guidelines. Thirty RCTs (n = 4817) were included. Meta-analysis showed that probiotic supplementation was associated with better short-term weight gain [SMD 0.24 (95%CI 0.04, 0.44); 22 RCTs (n = 3721); p = 0.02; I2 = 88%; CoE: low]. However, length [SMD 0.12 (95%CI −0.13, 0.36); 7 RCTs, (n = 899); p = 0.35; I2 = 69%; CoE: low] and head circumference [SMD 0.09 (95%CI −0.15, 0.34); 8 RCTs (n = 1132); p = 0.46; I2 = 76%; CoE: low] were similar between the probiotic and placebo groups. Probiotic supplementation had no effect on neurodevelopmental impairment [RR 0.91 (95%CI 0.76, 1.08); 5 RCTs (n = 1556); p = 0.27; I2 = 0%; CoE: low]. Probiotic supplementation was associated with better short-term weight gain, but did not affect length, head circumference, long-term growth, and neurodevelopmental outcomes of preterm infants. Adequately powered RCTs are needed in this area. Prospero Registration: CRD42020064992.

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A randomized control study on the effect of probiotics on feed tolerance in very low birth weight neonates

Senthil Kumaran G,

Chairman Muthu Prem Kumar L,

Jeyarama Krishnan R

2024

Asian J Med Sci

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Background: Probiotics are live microbial supplements that increase feed tolerance, colonize the gut of these newborns with beneficial flora, and promote growth in these infants. Aims and Objectives: This study was planned to compare the role of probiotics in low birth weight (LBW) infants in the time taken to reach full feeds, episodes of feed intolerance, weight gain, duration of hospital stay, incidence of necrotizing enterocolitis (NEC) stage 2 or more, and morbidity and mortality during hospital stay. Materials and Methods: This interventional two-arm blinded randomized control study was conducted in Thoothukudi Government Medical College Hospital, Thoothukudi, from November 2019 to October 2020. The selected sample of babies was randomly divided into two groups, the probiotic and the no-probiotic group. Bifidobacterium breve M-16 was administered to infants in the probiotic group at a dose of 0.5 g/day once a day in breast milk. Only breast milk was used to feed babies in the no-probiotic group. Results: The time to reach full enteral feed was shorter in the probiotic group (9.21±1.74 days) than in the no-probiotic group (12.43±3.74 days). Better feed tolerance (12%) was seen in the probiotic group than in the no-probiotic (44%) group. A low incidence of sepsis (12%) was seen in the probiotic group than in the non-probiotic group (40%). A lesser duration of hospital stay (10.42±1.77 days) was seen in the probiotic group than in the probiotic group (13.78±4.18 days). Conclusion: Very LBW neonates who received probiotic supplements along with their feeds have shorter times to reach full feeds, greater feed tolerance, lower rates of sepsis, and shorter mean hospital stays.

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Probiotic Supplementation and Its Effect on Weight and Feed tolerance in Preterm Low Birth Weight Newborns: A Clinical Trial

Abstract: Abstract

Cited by 3 publications

References 19 publications

Effect of Probiotics on Full Intestinal Feeding in Premature Infants: A Double Blind, Clinical Trial

Effect of Probiotics on Full Intestinal Feeding in Premature Infants: A Double Blind, Clinical Trial

Growth and neuro-developmental outcomes of probiotic supplemented preterm infants—a systematic review and meta-analysis

A randomized control study on the effect of probiotics on feed tolerance in very low birth weight neonates

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