Probiotic Supplementation and Food Intake and Knowledge Among Patients and Consumers

Nguyen, Mimi; Ferge, K. K.; Vaughn, Alexandra R.; Burney, Waqas; Teng, Lay Heng; Pan, Adrianne; Nguyen, Van Chuyen; Sivamani, Raja K

doi:10.1007/s12602-019-09602-0

Cited by 13 publications

(13 citation statements)

References 43 publications

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“…Thus, Tekce et al (2015) observed that in patients treated with SD and probiotics re-colonization with anaerobic microorganisms was slowed for up to 6 months, which is also consistent with our findings [ 59 ]. However, several other mechanisms of action have been proposed for probiotics, including modulation of host response, production of antibacterial substance, competitive exclusion, competition for essential nutrients, and enhancement of mucosal barrier function [ 63 ]. In this context, it has also to be considered that different strains of probiotics are available as an adjunct in periodontal treatment and that these can provide different benefits.…”

Section: Discussionmentioning

confidence: 99%

Effects of adjunctive light-activated disinfection and probiotics on clinical and microbiological parameters in periodontal treatment: a randomized, controlled, clinical pilot study

et al. 2021

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Objectives The aim of this pilot study was to evaluate the clinical and microbiological outcomes of light-activated disinfection (LAD) alone or combined with probiotics as an adjunct to non-surgical periodontal treatment. Materials and methods In this single-blinded, randomized, controlled clinical pilot study, 48 patients (28 females and 20 males) with untreated periodontitis (stages II and III, grade B) were included. Using a parallel-group design, patients were randomly assigned into 3 groups to receive subgingival debridement (SD) alone (group 1, n = 16), SD with LAD (group 2, n = 16), or SD with LAD plus probiotic treatment (group 3, n = 16). Probing pocket depth (PPD), clinical attachment level (CAL), bleeding on probing (BOP), gingiva-index simplified (GIs), plaque-control record (PCR), and subgingival microbiological samples were analyzed at baseline, 3 months, and 6 months of follow-up. Results All treatment modalities demonstrated clinical improvements in PPD and CAL at 6 months compared to baseline but without a statistical significant difference between the groups. The combination of SD + LAD + probiotic treatment (group 3) demonstrated significantly greater reductions in BOP, GIs, and red complex bacteria P. gingivalis and T. forsythia compared with other groups at 6 months (p < 0.05). Conclusions A single application of LAD as an adjunct to SD provided no additional clinical and microbiological benefits compared to SD alone. The combination of SD + LAD + probiotic treatment in group 3 led to further improvements of the inflammatory parameters. Clinical relevance The additional use of probiotics in periodontal treatment can be a useful approach to support inflammation and infection control of periodontal tissues. Further studies are necessary to determine the extent of added benefit for this treatment approach.

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Section: Discussionmentioning

confidence: 99%

Effects of adjunctive light-activated disinfection and probiotics on clinical and microbiological parameters in periodontal treatment: a randomized, controlled, clinical pilot study

et al. 2021

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“…In comparison to three times daily dosing, these formulations may lead to better compliance and adherence to therapy [ 14 ]. Evidence in the literature suggests that differences in delivery method and frequency of administration of probiotics can impact the effectiveness and are recognised by patients as important factors [ 19 , 20 ]. Availability of once-daily dose formulations may increase adherence to medication.…”

Section: Discussionmentioning

confidence: 99%

Kinetics of Intestinal Presence of Spores Following Oral Administration of Bacillus clausii Formulations: Three Single-Centre, Crossover, Randomised, Open-Label Studies

Navarra

Milleri

Perez

et al. 2021

Eur J Drug Metab Pharmacokinet

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Background and Objective Probiotics are live microorganisms that may provide benefits including the prevention of gastrointestinal disorders and other diseases. Enterogermina is a probiotic mix of spores from four strains of Bacillus clausii (O/C, T, N/R and SIN), available in several oral formulations. The objective of this analysis was to evaluate and compare the kinetic profiles of different formulations of Enterogermina-vial [E4 once daily (OD) and E2 twice daily (BID)], capsule [EC2 three times daily (TID)], oral powder for suspension (ES6 OD) and oral powder not requiring suspension (E6 OD) from two studies from 2012 (EUDRACT 2010-024497-19 and 2010-023187-41) and one study from 2016 (EUDRACT 2015-003330-27). Methods B. clausii spores were counted in homogenised faecal samples (results expressed as counts per gram) or after culture at 37 °C for 24-36 h (results expressed as colony-forming units). Kinetics were assessed by area under the concentrationtime curve (AUC), maximum concentration (C max ), time to maximum concentration (T max ) and spore presence/persistence. Results In total, 22 subjects in each of the 2012 studies and 30 subjects in the 2016 study were randomised (mean age 25.0-33.8 years across studies). The mean (±SD) absolute faecal spore counts (in millions) expressed as AUC per hour were 270.

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“…Altogether, the efficacious clinical trials summarized here are likely to fuel further studies and the development of new therapies based on our ever-growing knowledge of the relation of GM and bone metabolism. Moreover, patient surveys in the USA have shown the great acceptance of prebiotics and probiotics suggesting that microbiome-based therapies could increase treatment compliance in patients [ 105 , 106 ].…”

Section: Future Perspectivesmentioning

confidence: 99%

The Gut Microbiome: a New Frontier in Musculoskeletal Research

Boer

Oei

et al. 2021

Curr Osteoporos Rep

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Purpose of the review The human gut harbors a complex community of microbes that influence many processes regulating musculoskeletal development and homeostasis. This review gives an update on the current knowledge surrounding the impact of the gut microbiota on musculoskeletal health, with an emphasis on research conducted over the last three years. Recent findings The gut microbiota and their metabolites are associated with sarcopenia, osteoporosis, osteoarthritis, and rheumatoid arthritis. The field is moving fast from describing simple correlations to pursue establishing causation through clinical trials. Summary The gut microbiota and their microbial-synthesized metabolites hold promise for offering new potential alternatives for the prevention and treatment of musculoskeletal diseases given its malleability and response to environmental stimuli.

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Probiotic Supplementation and Food Intake and Knowledge Among Patients and Consumers

Cited by 13 publications

References 43 publications

Effects of adjunctive light-activated disinfection and probiotics on clinical and microbiological parameters in periodontal treatment: a randomized, controlled, clinical pilot study

Effects of adjunctive light-activated disinfection and probiotics on clinical and microbiological parameters in periodontal treatment: a randomized, controlled, clinical pilot study

Kinetics of Intestinal Presence of Spores Following Oral Administration of Bacillus clausii Formulations: Three Single-Centre, Crossover, Randomised, Open-Label Studies

The Gut Microbiome: a New Frontier in Musculoskeletal Research

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