Probiotic roles of<i>Lactobacillus</i>sp. in swine: insights from gut microbiota

Valeriano, Valerie Diane; Balolong, Marilen P.; Kang, Dae‐Kyung

doi:10.1111/jam.13364

Cited by 199 publications

(181 citation statements)

References 98 publications

(182 reference statements)

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“…Previous studies have reported that oral administration of Lactobacillus changes the structure of the gut microbiota, influencing intestinal mucosal immunity and host metabolism (Valeriano et al, ). For example, administration of L. frumenti JCM 11122 increased the abundance of L. frumenti in the faeces of early weaned piglets, and treatment with L. reuteri ZLR003 significantly altered the microbial diversity and community composition in the intestinal contents of weaned piglets (Hu et al, ; Zhang et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Lactobacillus colonizes the proximal and distal regions of the porcine digestive tract soon after birth and is one of the core genera in the gastrointestinal tracts of pigs (Mesquita et al, ; Valeriano, Balolong, & Kang, ). Many studies have revealed that Lactobacillus has the potential to regulate host immune systems, enhance gut metabolic capacities and maintain balance in the gut microbiota (Hou, Zeng, Yang, Liu, & Qiao, ; Zhang et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…These results are consistent with the results obtained in our study, where the increase in TLR4 expression was accompanied by increased TLR2 expression. Furthermore, our findings suggest that L. plantarum 299v may have a stronger influence on ileal intestinal barrier function than other intestinal segments of suckling piglets.Previous studies have reported that oral administration ofLactobacillus changes the structure of the gut microbiota, influencing intestinal mucosal immunity and host metabolism(Valeriano et al, 2017). For example, administration of L. frumenti JCM 11122 increased the abundance of L. frumenti in the faeces of early weaned piglets, and treatment with L. reuteri ZLR003 significantly altered the microbial diversity and community composition in the intesti-Effects of L. plantarum 299v on the bacterial community structure in the colonic digesta.…”

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confidence: 96%

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Effects of Lactobacillus plantarum on the intestinal morphology, intestinal barrier function and microbiota composition of suckling piglets

Wang

Sun

et al. 2019

Animal Physiology Nutrition

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This study investigated the effect of Lactobacillus plantarum strain 299v on gut health in suckling piglets. Sixty newborn piglets were assigned to control and probiotic treatments, with three litters per treatment (ten piglets/litter). From days 1 to 20 of life, piglets were orally administered a placebo of 0.1% peptone or 1.0 × 1010 CFU L. plantarum 299v daily. Six piglets per treatment were sacrificed on day 20, and intestinal tissues (including duodenum, jejunum, ileum and colon) and the intestinal contents from colon segments were collected. The results demonstrated that piglets treated with L. plantarum 299v had a lower diarrhoea incidence than the controls. L. plantarum 299v administration significantly increased the ratio of the villus height to the crypt depth in the jejunum and ileum, as well as the mRNA expression of jejunal occludin and ileal zonula occludens 1 (ZO‐1). The L. plantarum treatment also increased the mRNA abundance of porcine β‐defensin 2 (pBD2) and pBD3 in the jejunum and ileum and of toll‐like receptors (TLRs), such as TLR2, TLR4, TLR6 and TLR9 in the ileum, and significantly upregulated the mRNA abundances of ileal pBD1 and colonic TLR4. Additionally, the L. plantarum 299v treatment significantly changed the structure of the colonic microbiota, as evidenced by the obvious increases in the relative abundances of the phyla Firmicutes and Actinobacteria and of the genus Lactobacillus. Our findings indicate that L. plantarum 299v facilitates the gut health of suckling piglets, probably by improving the intestinal morphology and intestinal barrier function and by modifying the structure of the gut microbiota.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 96%

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Effects of Lactobacillus plantarum on the intestinal morphology, intestinal barrier function and microbiota composition of suckling piglets

Wang

Sun

et al. 2019

Animal Physiology Nutrition

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“…In contrast to the human study [45], this was a longterm effect in our study, probably as a consequence of an impaired maturation of the microbiota, as this effect was only detectable on day 97 of life. Members of the Lactobacillaceae are known to have many health promoting properties [46] including prevention of adhesion of opportunistic pathogens via attaching to the mucus layer in the gut [47]. They also produce lactate which is utilized by other bacteria to convert it into propionate, valerate, and butyrate [48].…”

Section: Discussionmentioning

confidence: 99%

Early Parenteral Administration of Ceftiofur has Gender-Specific Short- and Long-Term Effects on the Fecal Microbiota and Growth in Pigs from the Suckling to Growing Phase

Ruczizka

Metzler‐Zebeli

Unterweger

et al. 2019

Animals

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Simple Summary: Antibiotics are commonly used in prevention and therapy of bacterial diseases in pig production. Although the main target of antibiotics are the pathogenic bacteria, they often disrupt the commensal gut microbiota as a whole, leading to intestinal disturbances. These detrimental effects have been well established for oral administration of antibiotics, whereas knowledge about potential disturbing effects of single parenteral antibiotic treatments on the gut microbiota development is limited. In this research, the impact of a single antibiotic injection on the first day of life on the maturation of the fecal microbiome and host growth performance was evaluated from the suckling to the growing phase. Results showed that a single antibiotic injection early in life influenced the bacterial community development in the short-and long-term and that this disturbance in the bacterial community was sex-specific. Present results further demonstrated that changes in the bacterial ecosystem of the gut may impair the growth performance of the growing pig. Thus, the results of the present study emphasize the importance of a proper and strict use of antibiotics in swine herds.Abstract: Using ceftiofur during the first days of life is a common preventative strategy against several bacterial diseases in pig production. This study aimed to evaluate short-and long-term effects of early use of ceftiofur on the fecal microbiota development in suckling and growing pigs. Sixty-four piglets from eight litters were assigned to the antibiotic (AB; n = 32) or control group (control; n = 32). Twelve hours postpartum (day 0) AB piglets received an intramuscular injection of ceftiofur (5.0 mg/kg body weight) or a placebo. DNA was extracted from fecal samples collected on days 0, 12, 28, and 97 for deep-sequencing of the 16S rRNA gene. The AB administration disturbed the maturational changes in the fecal microbiome, whereby effects were sex-specific. Sex-related differences in AB metabolism in females and males may have caused these diverging AB-effects on the fecal microbiota. Especially the loss of bacterial diversity and of certain taxa in female AB pigs may have contributed to the decreased body weight of these females on day 97 of life. Taken together, this study showed that an AB injection with ceftiofur 12 h postpartum markedly affected the successional changes in the fecal microbiota composition in male and female pigs, with long-term consequences for host performance.

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“…Multiple lactic acid bacteria (LAB) are regarded as safe by the FDA [70]. Many of these bacteria are symbiotic with their hosts.…”

Section: Application Strategies Of Antimicrobial Peptidesmentioning

confidence: 99%

Host defense antimicrobial peptides as antibiotics: design and application strategies

Mishra

Reiling

Zarena

et al. 2017

Current Opinion in Chemical Biology

258

224

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This review deals with the design and application strategies of new antibiotics based on naturally occurring antimicrobial peptides (AMPs). The initial candidate can be designed based on three-dimensional structure or selected from a library of peptides from natural or laboratory sources followed by optimization via structure-activity relationship studies. There are also advanced application strategies such as induction of AMP expression from host cells by various factors (e.g., metals, amino acids, vitamin D and sunlight), the use of engineered probiotic bacteria to deliver peptides, the design of prodrug and peptide conjugates to improve specific targeting. In addition, combined uses of newly developed AMPs with existing antimicrobial agents may provide a practical avenue for effective management of antibiotic-resistant bacteria (superbugs, including biofilm). Finally, we highlight AMPs already in use or under clinical trials.

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Probiotic roles ofLactobacillussp. in swine: insights from gut microbiota

Cited by 199 publications

References 98 publications

Effects of Lactobacillus plantarum on the intestinal morphology, intestinal barrier function and microbiota composition of suckling piglets

Effects of Lactobacillus plantarum on the intestinal morphology, intestinal barrier function and microbiota composition of suckling piglets

Early Parenteral Administration of Ceftiofur has Gender-Specific Short- and Long-Term Effects on the Fecal Microbiota and Growth in Pigs from the Suckling to Growing Phase

Host defense antimicrobial peptides as antibiotics: design and application strategies

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