Probiotic mitigates the toxic effects of potassium dichromate in a preclinical study: a randomized controlled trial

Younan, Soraia; Sakita, Gabriel Zanuto; Coluna, João Gabriel Younan; Rufino, Marcos Natal; Keller, Rogéria; Bremer‐Neto, Hermann

doi:10.1002/jsfa.9159

Cited by 7 publications

(5 citation statements)

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“…Lactobacillus strains were able to produce intracellular cholesterol reductase, and extracellular cholesterol reductase was also detected, indicating that the bioconversion of cholesterol to coprostanol could also occur outside the cell, and this could benefit the host by reducing blood cholesterol levels (Lye et al, 2010;Nocianitri et al, 2017). In addition, the results revealed the ability of probiotic microorganisms to remedy the deleterious effects of chromium present in cigarette smoke, increasing HDL levels and decreasing LDL (Younan et al, 2018).…”

Section: Discussionmentioning

confidence: 97%

“…In murines and humans, due to the large number of numerous harmful agents in its composition, chronic exposure to cigarette smoke has been shown to cause oxidative stress. This effect has been mitigated by supplementation of functional foods (probiotics, prebiotics, and symbiotics) because of the anti-inflammatory, immunomodulator, and antioxidant roles of these compounds (Bezerra et al, 2015;George Kerry et al, 2018;Gibson et al, 2017;Hamed et al, 2018;Hill et al, 2014;Younan et al, 2018). From this perspective, it is suggested that supplementation in the diet with functional foods, in suitable quantities and periodicity can have beneficial systemic effects, however, there is little evidence regarding physiological and biochemical parameters, particularly using the pool of probiotic microorganisms: Lactobacillus acidophilus, Enterococcus faecium, Bifidobacterium thermophilum, and Bifidobacterium longum; the prebiotic mananoligosaccharide (MOS), and symbiotics resulting from the mixture of both.…”

Section: Introductionmentioning

confidence: 99%

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Probiotics, prebiotics and symbiotics attenuate chronic effects of passive smoking on physiological and biochemical parameters in rats: A randomized and controlled study

Rombi

Lopes

Ortiz

et al. 2021

RSD

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Passive and chronic exposure to tobacco smoke is a major cause of preventable diseases in humans and animals. The aim of this study was to evaluate the physiological and biochemical effects of functional foods: probiotics, prebiotics, and symbiotics in young rats exposed chronically to cigarette smoke. Ninety-six young male rats were randomly assigned to eight groups (n = 12): control (C); probiotic (Pro); prebiotic (Pre); symbiotic (Sym); smoking control (CS); smoking probiotic (ProbS); smoking prebiotic (PrebS); and smoking symbiotic (SymbS). After the experimental period of 189 days, the animals were anesthetized, blood samples were collected, and the animals were euthanized by exsanguination. The data were submitted to the Shapiro Wilk test, followed by the one-way ANOVA test, with contrasts by the Tukey method (P<0.05). The results demonstrated that chronic passive exposure to cigarette smoke had deleterious effects on the animals, and that these effects were attenuated in groups of animals supplemented with functional foods. In the supplemented groups there were significant improvements in weight gain, and mean values of liver enzymes (ALT, AST, GGT, and ALP), serum proteins (albumin and globulins), blood glucose, uremia, and creatininemia. We conclude that functional foods, probiotics, prebiotics, and symbiotics, attenuate the deleterious effects on the physiological and biochemical parameters of rats chronically exposed to cigarette smoke.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Probiotics, prebiotics and symbiotics attenuate chronic effects of passive smoking on physiological and biochemical parameters in rats: A randomized and controlled study

Rombi

Lopes

Ortiz

et al. 2021

RSD

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“…Response heterogeneity is a common phenomenon in RCT, especially in disease-related studies. [60] This heterogeneity was explored in terms of baseline gut microbial profiles, and indicated that in the gut microbiota of poorly responding individuals during juice intervention, the probiotic B. thermophilum was depleted [61] , whereas opportunistic pathogens were enriched, which included E. coli [62] , B. ovatus [63] and P.…”

Section: Discussionmentioning

confidence: 99%

Supplementation with Berry Juice and Vitamin E Ameliorates Blood Cholesterol Level and Alters Gut Microbiota Composition

Chen

et al. 2023

Preprint

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Scope: Antioxidants, including vitamin E (VE) and grape seed extract, as anti-aging supplementation have been widely used to improve human health. However, the role of gut microbiota in dietary antioxidant supplementation is debatable. This study aimed to assess the longitudinal impact of dietary supplementation with antioxidant compounds on body health and the gut microbiota. Methods and results: One hundred and twenty healthy individuals were randomly divided into a placebo group (amylodextrin) and three experimental groups ingesting different supplement (VE, grape seed extract, or mixed berry juice). Blood and fecal samples were collected during three intervention phases. We found that VE and mixed berry juice ameliorated blood cholesterol levels by reducing the levels of low-density lipoprotein cholesterol (LDL-C) in healthy volunteers. After the intervention, there was an increase in the relative abundance of short-chain fatty acid (SCFA)-producing bacteria and bile acid metabolizers. Specifically, the abundances of Lachnospira sp. and Faecalibacterium spp. increased in the VE and berry juice groups. Interestingly, the gut microbiota of poor responders harbored a greater proportion of disease-associated bacterial species. Conclusion: Juice and VE could promote health by lowering LDL-C, partly and indirectly by affecting gut bacteria with the ability to produce SCFAs or metabolize bile acids.

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“…Portions of these organs were fixed in 10% formalin (Chemical Kinetics, São Paulo, Brazil) for 24 hours and subjected to standard histological processing and paraffin embedding (Dynamic Analytical Reagents, São Paulo, Brazil). Serial sections with a thickness of 5 μm were obtained using a LEICA microtome RM2265 (Leica Biosystems Nussoch GmbH, Germany) and stained with hematoxylin-eosin (HE) (Younan et al, 2019).…”

Section: Histopathologymentioning

confidence: 99%

Influence of water pH in the hepato- and nephrotoxicity of chronic cadmium poisoning in Wistar rats

Bonfim

García

Laposy

et al. 2021

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Introduction: Cadmium is a heavy metal found in the environment that is used industrially; however, it also causes hepato- and nephrotoxic effects. Objective: To evaluate the effect of drinking water pH on the hepato- and nephrotoxicity caused by chronic cadmium poisoning. Material and Methods: We used 90 adult, male Wistar albino rats divided into 6 groups (n = 15): GC5 received a solution of cadmium chloride in drinking water with an acidic pH (pH 5.0); GC7 received a solution of cadmium chloride (400 mg/L) in drinking water with a neutral pH (pH 7.0 water); GC8 received a solution of cadmium chloride in water with an alkaline pH (pH 8.0); GWC5 received drinking water with an acidic pH (pH 5.0); GWC7 received drinking water with a neutral pH (pH 7.0); GWC8 received drinking water with an alkaline pH (pH 8.0). The animals were euthanized 6 months after the start of the experiment. We performed tests for hepatic and renal function and conducted liver and renal histopathology. Results: Water with an acidic pH caused alterations in ALP, ALT and urea in animals exposed to cadmium (P<0.05). In the liver, the majority of animals from the GC7 (57.1%) and GC5 (53.3%) groups showed diffuse microvesicular steatosis, while other groups showed no steatosis (P>0.05). In the kidney, the majority of animals from the GC7 (78.6%) and GWC5 (71.4%) groups showed tubular hydropic degeneration; however, these data were only statistically different from the GWC7 group (P<0.05). Conclusion: Exposure to cadmium in water with an acidic pH led to higher elevations of serum ALP, AST and urea, suggesting that the pH of drinking water influences the hepato- and nephrotoxic effects of this heavy metal.

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Probiotic mitigates the toxic effects of potassium dichromate in a preclinical study: a randomized controlled trial

Abstract: Supplementation with probiotics in the diet beneficially modified the nutritional and physiological parameters, as well as hepatic, renal, glycemic and lipid profiles, of animals intoxicated with increasing doses of K Cr O . © 2018 Society of Chemical Industry.

Cited by 7 publications

References 46 publications

Probiotics, prebiotics and symbiotics attenuate chronic effects of passive smoking on physiological and biochemical parameters in rats: A randomized and controlled study

Probiotics, prebiotics and symbiotics attenuate chronic effects of passive smoking on physiological and biochemical parameters in rats: A randomized and controlled study

Supplementation with Berry Juice and Vitamin E Ameliorates Blood Cholesterol Level and Alters Gut Microbiota Composition

Influence of water pH in the hepato- and nephrotoxicity of chronic cadmium poisoning in Wistar rats

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