Probiotic Lactobacillus rhamnosus GG and Aloe vera gel improve lipid profiles in hypercholesterolemic rats

Kumar, Manoj; Rakesh, Shruti; Nagpal, Ravinder; Hemalatha, R.; Ramakrishna, A.; Sudarshan, V.; Ramagoni, Ramesh; Shujauddin, Mohd; Verma, Vinod; Kumar, Amrendra; Tiwari, Akhilesh; Singh, Birbal; Kumar, Rajesh

doi:10.1016/j.nut.2012.09.006

Cited by 82 publications

(55 citation statements)

References 34 publications

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“…can alter the gut microbial population and influence the incidence of CRC [2,19,33,34]. Among the beneficial effects of probiotics observed in humans are the stimulation of gut immunity through various mechanisms, prevention of diarrhea and enhanced tolerance to lactose [35].…”

Section: Probiotics As Versatile Therapeutic Agentsmentioning

confidence: 99%

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Epigenetics, Probiotic Metabolites and Colon Cancer Prevention: An Overview of Progress, Opportunities and Challenges

Kumar¹,

Hemalatha²,

Kumar³

et al. 2013

Med Epigenet

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Colorectal cancer (CRC) is a common epithelial neoplasia across the globe, with about 1.2 million newly diagnosed cases and over 600,000 mortalities annually. The underlying causes are numerous including dietary ingredients, environmental factors and gut metabolome that affect colon cellular gene regulation and post-translational modifications of the proteome. Collectively, these alterations initiate epigenetic modifications leading to the inception of various metabolic diseases and malignancies. Epigenetics is at the core of modern medicine since it deals with complex processes that turn the expression of certain genes on and off, and it elucidates the mechanisms and connections between genotypes and the environment during various stages of life. However, the majority of the vertical molecular mechanisms with reference to epigenomics, epigenetic and metabolic ailments are still unidentified and need further research. This article summarizes the burgeoning role of probiotic metabolites and some prominent therapeutic dietary ingredients in the management of CRC.

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Section: Probiotics As Versatile Therapeutic Agentsmentioning

confidence: 99%

“…Dietary interventions for preventing colon cancer have recently emerged as viable alternatives to manage colon cancers [2,34]. It is envisaged that the supplementation of bacterial ingredients with the ability to synthesize anticancer metabolites (e.g.…”

Section: Future Directionsmentioning

confidence: 99%

Epigenetics, Probiotic Metabolites and Colon Cancer Prevention: An Overview of Progress, Opportunities and Challenges

Kumar¹,

Hemalatha²,

Kumar³

et al. 2013

Med Epigenet

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“…Probiotics could improve gut health by inhibiting the growth and attachment of harmful bacteria [13]. In addition to improving gut health, probiotics have also been reported to exert to other health-promoting effects against many kinds of diseases, including hypertension [14], cancer [15], allergic symptoms [16], arthritis [17], hyperlipidemia [18], and so on. In particular, probiotics have also been studied for their cholesterol-lowering effects in animal and human studies.…”

Section: Introductionmentioning

confidence: 99%

Hypocholesterolemic Effects of Probiotic Mixture on Diet-Induced Hypercholesterolemic Rats

Kim

Park²,

Sin

et al. 2017

Nutrients

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Growing evidence has indicated that supplementation with probiotics improves lipid metabolism. We aimed to investigate the beneficial effects of a probiotics mixture (PM) of three strains belonging to the species Bifidobacterium (B. longum, B. lactis, and B. breve) and two strains belonging to the species Lactobacillus (L. reuteri and L. plantarum) on cholesterol-lowering efficacy in hypercholesterolemic rats. A hypercholesterolemic rat model was established by feeding a high-cholesterol diet for eight weeks. To test the effects of PM on hypercholesterolemia, hypercholesterolemic rats were assigned to four groups, which were treated daily with low (1.65 × 109 cfu/kg), medium (5.5 × 109 cfu/kg), or high (1.65 × 1010 cfu/kg) doses of probiotic mixture or simvastatin for eight weeks. Significant reductions of serum total cholesterol (TC), triacylglycerol (TG), and low-density lipoprotein (LDL)-cholesterol levels, but increases of high-density lipoprotein (HDL)-cholesterol were observed after supplementation of PM in hypercholesterolemic rats. In PM-supplemented hypercholesterolemic rats, hepatic tissue contents of TC and TG also significantly decreased. Notably, the histological evaluation of liver tissues demonstrated that PM dramatically decreased lipid accumulation. For their underlying mechanisms, we demonstrated that PM reduced expressions of cholesterol synthesis-related proteins such as sterol regulatory element-binding protein 1 (SREBP1), fatty acid synthase (FAS), and acetyl-CoA carboxylase (ACC) in the liver. Taken together, these findings suggest that PM has beneficial effects against hypercholesterolemia. Accordingly, our PM might be utilized as a novel therapeutic agent for the management of hypercholesterolemia.

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“…Recent animal study on supplementation of Aloe vera gel with microbiota presented the antihypercholesterolemic effect of the probiotic Lactobacillus rhamnosus GG (LGG) plus Aloe vera gel in rats with induced hypercholesterolemia, where serum cholesterol, LDL, VLDL, and TAG levels were found to be decreased significantly, and HDL cholesterol levels were observed to be increased significantly. An optimized blend of the probiotic LGG and Aloe vera gel could be exploited as a potential herboprobiotic therapy to decrease cholesterol levels and lower the risk of cardiovascular disease, although the field is open for further studies [96] . Natural health product (NHP) or comprehensive and alternative medicine (CAM) use is common in patients admitted with acute cardiac-vascular disease.…”

Section: Resultsmentioning

confidence: 99%

Putative Prophylaxes of Aloe Vera for Age-Related Diseases

Yagi

2015

Journal of Gastroenterology and Hepatology Research

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The aim of the present review is focused on putative prophylaxes of Aloe vera for age-related diseases, and its check items are generally known traditional and specific diseases followed by In vitro, animal, and preliminary clinical studies: (1) prevention of cancer and alleviation of progeria; (2) prevention of cardiovascular and cerebro-vascular disorders, and inhibition of acetylcholinesterase; (3) preliminary clinical study of an aloemannose multinutrient complex on cognitive and immune functioning in Alzheimer's disease; (4) prevention of photo-aging and polycystic ovarian syndrome; (5) stimulation of periodontal fibroblasts, bone formation, and healing of pain and nephro-toxicity; and (6) anti-inflammation and immuno-response, excluding diabetic and hepatic disorders.

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Probiotic Lactobacillus rhamnosus GG and Aloe vera gel improve lipid profiles in hypercholesterolemic rats

Cited by 82 publications

References 34 publications

Epigenetics, Probiotic Metabolites and Colon Cancer Prevention: An Overview of Progress, Opportunities and Challenges

Epigenetics, Probiotic Metabolites and Colon Cancer Prevention: An Overview of Progress, Opportunities and Challenges

Hypocholesterolemic Effects of Probiotic Mixture on Diet-Induced Hypercholesterolemic Rats

Putative Prophylaxes of Aloe Vera for Age-Related Diseases

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