Probiotic Lactobacillus rhamnosus alleviates the neurotoxicity of microcystin-LR in zebrafish (Danio rerio) through the gut-brain axis

Luan, Ning; Zuo, Junli; Niu, Qianping; Yan, Wei; Hung, Tien-Chieh; Liu, Haoling; Wu, Qin; Wang, Guoao; Deng, Ping; Ma, Xufa; Qin, Jianhui; Li, Guangyu

doi:10.1016/j.scitotenv.2023.168058

Cited by 6 publications

(2 citation statements)

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“…Luan et al found that zebrafish exposed to MCLR reduced their swimming speed but the presence of L. rhamnosus could counteract this abnormality by modulating the transmission within the gut and brain. 143 Moreover, probiotic administration affects the gut−liver−brain axis and the gut−brain axis. In the zebrafish model, SLAB51 146 Improvement of motor symptoms in the 6-OHDA model of PD is seen on administration of probiotic formulation SLAB51.…”

Section: Gut-modulating Treatment Strategiesmentioning

confidence: 99%

“…Remarkably, Lactobacillus rhamnosus can mitigate the neurotoxicity caused by microcystin LR (MCLR), a cyanobacterial toxin, in zebrafish by regulating neural signaling in the brain and intestines, as well as neuroinflammation and HPA signaling response. Luan et al found that zebrafish exposed to MCLR reduced their swimming speed but the presence of L. rhamnosus could counteract this abnormality by modulating the transmission within the gut and brain . Moreover, probiotic administration affects the gut–liver–brain axis and the gut–brain axis.…”

Section: Gut-modulating Treatment Strategiesmentioning

confidence: 99%

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Unveiling the Journey from the Gut to the Brain: Decoding Neurodegeneration–Gut Connection in Parkinson’s Disease

Bhardwaj,

Singh,

Kumar

2024

ACS Chem. Neurosci.

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Parkinson's disease, a classical motor disorder affecting the dopaminergic system of the brain, has been as a disease of the brain, but this classical notion has now been viewed differently as the pathology begins in the gut and then gradually moves up to the brain regions. The microorganisms in the gut play a critical role in maintaining the physiology of the gut from maintaining barrier integrity to secretion of microbial products that maintain a healthy gut state. The pathology subsequently alters the normal composition of gut microbes and causes deleterious effects that ultimately trigger strong neuroinflammation and nonmotor symptoms along with characteristic synucleopathy, a pathological hallmark of the disease. Understanding the complex pathomechanisms in distinct and established preclinical models is the primary goal of researchers to decipher how exactly gut pathology has a central effect; the quest has led to many answered and some openended questions for researchers. We summarize the popular opinions and some contrasting views, concise footsteps in the treatment strategies targeting the gastrointestinal system.

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Section: Gut-modulating Treatment Strategiesmentioning

confidence: 99%

Section: Gut-modulating Treatment Strategiesmentioning

confidence: 99%