Probiotic Interventions for Oral Health

Twetman, Svante; Jørgensen, Mette Rose

doi:10.1007/978-981-33-6236-9_11

Cited by 5 publications

(5 citation statements)

References 76 publications

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“…Probiotic supplements and a prebiotic diet are encouraged for children who are deprived of natural breastfeeding to restore their oral microbiome and ensure good oral and dental health [ 50 , 51 ]. To reverse the undesired changes in the microbiota’s composition and function brought on by antibiotic treatments or caesarean delivery, a probiotic mixture in addition to at least partial breastfeeding is highly recommended [ 52 ]. More studies are needed to report the effect of antibiotic misuse in Egypt on several aspects of health, including oral health.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Cariogenic and Anti-Cariogenic Potential of Human Colostrum and Colostrum-Derived Probiotics: Impact on S. mutans Growth, Biofilm Formation, and L. rhamnosus Growth

Zaghloul,

Hashem,

El-Sayed

et al. 2023

Life

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Human colostrum (HC) is essential for oral health as it is rich in probiotics that could affect the growth of the cariogenic S. mutans and its biofilm formation; hindering dental caries in advance. In this study, HC was collected from 36 healthy mothers 1–3 days postpartum. The effect of HC on oral health was carried out by assessing the impact of HC and its derived probiotics’ cell-free supernatants (CFS) on the growth of S. mutans (using modified well diffusion) and its biofilm formation (using microtiter plate assay). Moreover, the effect of whole HC on L. rhamnosus, a probiotic oral bacterium, was examined. Probiotics were isolated and identified phenotypically by API 50 CH carbohydrate fermentation and genotypically by 16S rRNA amplification. The in vitro study revealed that HC has cariogenic activity and is associated with biofilm formation. Biofilm strength was inversely proportional to HC dilution (p-value < 0.0001). Nevertheless, HC and colostrum-derived probiotics improve oral health by inhibiting the growth of caries-inducing S. mutans with lower inhibition to L. rhamnosus probiotics. The CFS of isolated probiotics reduced the biofilm formation via the cariogenic S. mutans. These results are not only promising for caries eradication, but they also highlight the importance of breastfeeding infants from their first hours to shape healthy oral microbiota, protecting them from various diseases including dental caries.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the Cariogenic and Anti-Cariogenic Potential of Human Colostrum and Colostrum-Derived Probiotics: Impact on S. mutans Growth, Biofilm Formation, and L. rhamnosus Growth

Zaghloul,

Hashem,

El-Sayed

et al. 2023

Life

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“…The evidence supporting probiotics in maintaining oral health and preventing disease is also rapidly expanding. 23 Probiotics have demonstrated a reduction in dental caries, periodontal disease, peri-implantitis, oral candidiasis and halitosis. 23 , 40 Furthermore, there is evidence that probiotics can prevent and reduce upper respiratory infections.…”

Section: Discussionmentioning

confidence: 99%

“… 23 Probiotics have demonstrated a reduction in dental caries, periodontal disease, peri-implantitis, oral candidiasis and halitosis. 23 , 40 Furthermore, there is evidence that probiotics can prevent and reduce upper respiratory infections. 41 Although researchers initially tried to establish whether conventional approved intestinal probiotics could also influence the oral microbiome, these bacteria could not inhabit the oral mucosa.…”

Section: Discussionmentioning

confidence: 99%

“…The Human Microbiome Project identified over 700 species of bacteria that reside as commensals in the oral cavity. 23 As a result, several companies have developed various probiotic mixtures to create greater genetic diversity to restore the ‘natural’ microbiota. However, the comparative efficacy of mono-strain and multi-strain probiotics has not been adequately studied yet.…”

Section: Discussionmentioning

confidence: 99%

“…oral cavity, gastrointestinal tract, skin and vagina), with each performing specific functions beneficial to the host. 23 In 2001, Nobel prize laureate Joshua Lederberg coined the term ‘microbiome’, referring to the ecosystem of symbiotic, commensal and pathogenic microorganisms that reside in the human body. 24 The human microbiome is composed of all the genes isolated from microorganisms (bacteria, viruses and fungi) that reside on or within human tissues and biofluids.…”

Section: Introductionmentioning

confidence: 99%

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Can probiotic gargles reduce post-tonsillectomy morbidity in adult patients? A pilot, triple-blind, randomised, controlled trial and feasibility study

et al. 2022

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Objective This study aimed to determine the efficacy of probiotic gargles compared with placebo gargles on reducing post-tonsillectomy morbidity in adults. Method This was a triple-blind, randomised, controlled trial and feasibility study. Thirty adults underwent elective tonsillectomy and were randomly assigned to receive either probiotic or placebo gargles for 14 days after surgery. Daily pain scores and requirement of analgesia were measured for 14 days post-operatively. Secondary outcomes assessed probiotic safety and tolerability and the feasibility of the trial. Results The probiotic group experienced less pain at rest on day 2. However, the amount of oxycodone (5 mg) tablets used was greater in the probiotic group compared with placebo. There were no statistically significant differences in the frequency of adverse effects between both groups. This trial was feasible. Conclusion This pilot study suggested that probiotic gargles do not reduce post-tonsillectomy pain or bleeding, highlighting the importance of pilot and feasibility studies in clinical research.

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Prevention of Recurrent Childhood Caries with Probiotic Supplements: A Randomized Controlled Trial with a 12-Month Follow-Up

Hasslöf

Granqvist

Stecksén‐Blicks

et al. 2022

Probiotics & Antimicro. Prot.

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The aim of this study was to evaluate the effect of drops containing probiotic bacteria on the recurrence of dental caries in preschool children. The study employed a randomized, placebo-controlled, double-blinded design with two parallel arms. 38 preschool children were enrolled after comprehensive restorative treatment under general anesthesia or conscious sedation (baseline), and they were followed up after 6 and 12 months. Parents of children in the test group were instructed to give 5 daily drops containing two strains of Limosilactobacillus reuteri (DSM 17938 and ATCC PTA 5289) at bedtime. The placebo drops were identically composed but lacked bacteria. The duration of the intervention was 12 months. The primary endpoint was recurrence of new caries lesions on subject level (yes/no), and secondary endpoints were presence of dental plaque and gingivitis. We found high rate of recurrent moderate and extensive lesions after 12 months (67%) but there were no significant differences between the groups. We observed no beneficial effects on dental plaque or gingival inflammation. The findings were however uncertain and inconclusive due to lack of power, a consequence of the COVID-19 pandemic. ClinTrials.gov Identifier: (NCT04929340), June 18, 2021; retrospectively registered.

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Probiotic Interventions for Oral Health

Cited by 5 publications

References 76 publications

Evaluation of the Cariogenic and Anti-Cariogenic Potential of Human Colostrum and Colostrum-Derived Probiotics: Impact on S. mutans Growth, Biofilm Formation, and L. rhamnosus Growth

Evaluation of the Cariogenic and Anti-Cariogenic Potential of Human Colostrum and Colostrum-Derived Probiotics: Impact on S. mutans Growth, Biofilm Formation, and L. rhamnosus Growth

Can probiotic gargles reduce post-tonsillectomy morbidity in adult patients? A pilot, triple-blind, randomised, controlled trial and feasibility study

Prevention of Recurrent Childhood Caries with Probiotic Supplements: A Randomized Controlled Trial with a 12-Month Follow-Up

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