Probiotic infant cereal improves children’s gut microbiota: Insights using the Simulator of Human Intestinal Microbial Ecosystem (SHIME®)

Salgaço, Mateus Kawata; Perina, Natália P.; Tomé, Thaís Moreno; Mosquera, Elaine Martins Bento; Lazarini, Tamara; Sartoratto, Adilson; Sivieri, Kátia

doi:10.1016/j.foodres.2021.110292

Cited by 22 publications

(19 citation statements)

References 88 publications

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“…The gut microbiota plays a vital role in cyclic fission, hydrolysis, deamination, reduction, and dehydrogenation of complex nutrient to generate variety of metabolites (short chain fatty acids, hydrogen, alcohols, carbon dioxide, ammonia, choline derivatives, branched-chain fatty acids, phenols and indoles, and amines) which might be absorbed to blood and act throughout the host body [26][27][28]. Amongst these metabolites, the short chain fatty acids showed excellent ability to impact the preservation of colonic epithelial cells as these cells use them as an energy source [29]. Furthermore, the amino acid and lipid catabolism exert significant impact on composition of gut microbiota which in turn influence the host health [29].…”

Section: Composition Of Gut Microbiota and Their Impact On Host Healthmentioning

confidence: 99%

“…Amongst these metabolites, the short chain fatty acids showed excellent ability to impact the preservation of colonic epithelial cells as these cells use them as an energy source [29]. Furthermore, the amino acid and lipid catabolism exert significant impact on composition of gut microbiota which in turn influence the host health [29].…”

Section: Composition Of Gut Microbiota and Their Impact On Host Healthmentioning

confidence: 99%

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Role of Food Antioxidants in Modulating Gut Microbial Communities: Novel Understandings in Intestinal Oxidative Stress Damage and Their Impact on Host Health

et al. 2021

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Dietary components have an important role on the structure and function of host gut microbial communities. Even though, various dietary components, such as carbohydrates, fats, proteins, fibers, and vitamins, have been studied in depth for their effect on gut microbiomes, little attention has been paid regarding the impact of several food antioxidants on the gut microbiome. The long-term exposure to reactive oxygen species (ROS) can cause microbial dysbiosis which leads to numerous intestinal diseases such as microbiota dysbiosis, intestinal injury, colorectal cancers, enteric infections, and inflammatory bowel diseases. Recently, it has been shown that the food derived antioxidant compounds might protect the host from intestinal oxidative stress via modulating the composition of beneficial microbial species in the gut. The present review summarizes the impact of food antioxidants including antioxidant vitamins, dietary polyphenols, carotenoids, and bioactive peptides on the structure as well as function of host gut microbial communities. Several in vitro, animal model, and clinical studies indicates that food antioxidants might modify the host gut microbial communities and their health status. However, still further clarification is needed as to whether changes in certain microbial species caused by food additives may lead to changes in metabolism and immune function.

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Section: Composition Of Gut Microbiota and Their Impact On Host Healthmentioning

confidence: 99%

Section: Composition Of Gut Microbiota and Their Impact On Host Healthmentioning

confidence: 99%

Role of Food Antioxidants in Modulating Gut Microbial Communities: Novel Understandings in Intestinal Oxidative Stress Damage and Their Impact on Host Health

et al. 2021

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“…Bifidobacteria are recognized probiotics, which can indirectly exert probiotic effects by the immunomodulatory regulation of intestinal cells or modifying the function of normal microbiota. In particular, the Bifidobacterium BB12 can effectively promote the balance of intestinal microbiota and improve human immunity [ 36 ]. Figure 6 shows the heat map analysis of the level of intestinal microbiota, and the red shades represent the relative abundance of the microbiota.…”

Section: Resultsmentioning

confidence: 99%

Ultrasound Improved the Non-Covalent Interaction of β-Lactoglobulin with Luteolin: Regulating Human Intestinal Microbiota and Conformational Epitopes Reduced Allergy Risks

Wang

Chen

Shao

et al. 2022

Foods

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The present study aims to investigate the effects of ultrasound on the non-covalent interaction of β-lactoglobulin (β-LG) and luteolin (LUT) and to investigate the relationship between allergenicity and human intestinal microbiota. After treatment, the conformational structures of β-LG were changed, which reflected by the decrease in α-helix content, intrinsic fluorescence intensity and surface hydrophobicity, whereas the β-sheet content increased. Molecular docking studies revealed the non-covalent interaction of β-LG and LUT by hydrogen bond, van der Walls bond and hydrophobic bond. β-LG-LUT complex treated by ultrasound has a lower IgG/IgE binding ability and inhibits the allergic reaction of KU812 cells, depending on the changes in the conformational epitopes of β-LG. Meanwhile, the β-LG-LUT complex affected the composition of human intestinal microbiota, such as the relative abundance of Bifidobacterium and Prevotella. Therefore, ultrasound improved the non-covalent interaction of β-LG with LUT, and the reduction in allergenicity of β-LG depends on conformational epitopes and human intestinal microbiota changes.

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“…The composition of gut microbiota can be changed by antibiotics ( 112 ), prebiotics ( 113 ), probiotics ( 114 ), or microflora transplantation ( 115 ). The treatment of EC by regulating the microflora may become a novel treatment method.…”

Section: Harnessing Microbiota For Esophageal Cancer Therapy-related Applicationsmentioning

confidence: 99%

Gut Microbiota for Esophageal Cancer: Role in Carcinogenesis and Clinical Implications

et al. 2021

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Esophageal cancer (EC) is a common malignant tumor of the upper digestive tract. The microbiota in the digestive tract epithelium comprises a large number of microorganisms that adapt to the immune defense and interact with the host to form symbiotic networks, which affect many physiological processes such as metabolism, tissue development, and immune response. Reports indicate that there are microbial compositional changes in patients with EC, which provides an important opportunity to advance clinical applications based on findings on the gut microbiota. For example, microbiota detection can be used as a biomarker for screening and prognosis, and microorganism levels can be adjusted to treat cancer and decrease the adverse effects of treatment. This review aims to provide an outline of the gut microbiota in esophageal neoplasia, including the mechanisms involved in microbiota-related carcinogenesis and the prospect of utilizing the microbiota as EC biomarkers and treatment targets. These findings have important implications for translating the use of gut microbiota in clinical applications.

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Probiotic infant cereal improves children’s gut microbiota: Insights using the Simulator of Human Intestinal Microbial Ecosystem (SHIME®)

Cited by 22 publications

References 88 publications

Role of Food Antioxidants in Modulating Gut Microbial Communities: Novel Understandings in Intestinal Oxidative Stress Damage and Their Impact on Host Health

Role of Food Antioxidants in Modulating Gut Microbial Communities: Novel Understandings in Intestinal Oxidative Stress Damage and Their Impact on Host Health

Ultrasound Improved the Non-Covalent Interaction of β-Lactoglobulin with Luteolin: Regulating Human Intestinal Microbiota and Conformational Epitopes Reduced Allergy Risks

Gut Microbiota for Esophageal Cancer: Role in Carcinogenesis and Clinical Implications

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