Probiotic <i>Lactobacillus rhamnosus</i> Supplementation Improved Capecitabine Protective Effect against Gastric Cancer Growth in Male BALB/c Mice

Rahimi, Alireza; Nabavizadeh, Fatemeh; Ashabi, Ghorbangol; Halimi, Shahnaz; Rahimpour, Milad; Vahedian, Jalal; Panahi, Mahshid

doi:10.1080/01635581.2020.1832237

Cited by 9 publications

(3 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Various studies indicate that L. rhamnosus could exert anticancer effects on various gastrointestinal cancer cell lines, including HT-29 and AGS cancer cell lines 54 , 55 . The results of the research conducted by Dehghani et al demonstrated that L. rhamnosus has the ability to inhibit HT-29 cell growth and induce apoptosis.…”

Section: Discussionmentioning

confidence: 99%

The inhibition effects of Lentilactobacillus buchneri-derived membrane vesicles on AGS and HT-29 cancer cells by inducing cell apoptosis

Abedi,

Tafvizi,

Jafari

et al. 2024

Sci Rep

View full text Add to dashboard Cite

In recent years, probiotics and their derivatives have been recognized as important therapeutic agents in the fight against cancer. Therefore, this study aimed to investigate the anticancer effects of membrane vesicles (MVs) from Lentilactobacillus buchneri strain HBUM07105 probiotic isolated from conventional and unprocessed yogurt in Arak province, Iran, against gastric and colon cancer cell lines. The MVs were prepared from the cell-free supernatant (CFS) of L. buchneri and characterized using field-emission scanning electron microscopy (FE-SEM) and transmission electron microscopy (TEM) and SPS-PAGE techniques. The anticancer activity of MVs was evaluated using MTT, flow cytometry, qRT-PCR techniques, and a scratch assay. The study investigated the anti-adenocarcinoma effect of MVs isolated from L. buchneri on a human gastric adenocarcinoma cell line (AGS) and a human colorectal adenocarcinoma cell line (HT-29) at 24, 48, and 72-h time intervals. The results demonstrated that all prepared concentrations (12.5, 25, 50, 100, and 200 µg/mL) of MVs reduced the viability of both types of human adenocarcinoma cells after 24, 48, and 72 h of treatment. The analysis of the apoptosis results revealed that the percentage of AGS and HT-29 cancer cells in the early and late stages of apoptosis was significantly higher after 24, 48, and 72 h of treatment compared to the untreated cancer cells. After treating both AGS and HT-29 cells with the MVs, the cells were arrested in the G0/G1 phase. These microvesicles demonstrate apoptotic activity by increasing the expression of pro-apoptotic genes (BAX, CASP3, and CASP9). According to the scratch test, MVs can significantly decrease the migration of HT-29 and AGS cancer cells after 24, 48, and 72 h of incubation compared to the control groups. The MVs of L. buchneri can also be considered a potential option for inhibiting cancer cell activities.

show abstract

Section: Discussionmentioning

confidence: 99%

The inhibition effects of Lentilactobacillus buchneri-derived membrane vesicles on AGS and HT-29 cancer cells by inducing cell apoptosis

Abedi,

Tafvizi,

Jafari

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

“…It has been demonstrated that FOLFOX reduces the variety of the whole microbiome, and intriguingly, this diversity was reduced in patients who reacted to the FOLFOX rather than in nonresponders ( 333 – 335 ). Lactobacillus rhamnosus , a probiotic, improved the effectiveness of capecitabine against mouse GC growth ( 336 ). Cyclophosphamide (CTX) inhibits several immunological signaling cascades to produce its anticancer action ( 337 ).…”

Section: Microbiomes and Therapies For Gastrointestinal Cancersmentioning

confidence: 99%

The role of microbiomes in gastrointestinal cancers: new insights

Yarahmadi,

Afkhami

2024

Front. Oncol.

View full text Add to dashboard Cite

Gastrointestinal (GI) cancers constitute more than 33% of new cancer cases worldwide and pose a considerable burden on public health. There exists a growing body of evidence that has systematically recorded an upward trajectory in GI malignancies within the last 5 to 10 years, thus presenting a formidable menace to the health of the human population. The perturbations in GI microbiota may have a noteworthy influence on the advancement of GI cancers; however, the precise mechanisms behind this association are still not comprehensively understood. Some bacteria have been observed to support cancer development, while others seem to provide a safeguard against it. Recent studies have indicated that alterations in the composition and abundance of microbiomes could be associated with the progression of various GI cancers, such as colorectal, gastric, hepatic, and esophageal cancers. Within this comprehensive analysis, we examine the significance of microbiomes, particularly those located in the intestines, in GI cancers. Furthermore, we explore the impact of microbiomes on various treatment modalities for GI cancer, including chemotherapy, immunotherapy, and radiotherapy. Additionally, we delve into the intricate mechanisms through which intestinal microbes influence the efficacy of GI cancer treatments.

show abstract

“…Studies have reported Lactobacillus rhamnosus (LGG) and Bifidobacterium longum’s functions in anti-inflammatory, anti-cancer, anti-metastasis, 15 , 16 , 17 , 18 and enhancing the function of dendritic cells, and specifically augmenting T cell responses. 19 , 20 In addition, B. longum administration could reduce intestinal inflammation without impairing the antitumor function of CTLA-4 in mice.…”

Section: Introductionmentioning

confidence: 99%

Probiotics formulation and cancer nanovaccines show synergistic effect in immunotherapy and prevention of colon cancer

Xu¹,

Zhao²,

Liu³

et al. 2023

iScience

View full text Add to dashboard Cite

Probiotic Lactobacillus rhamnosus Supplementation Improved Capecitabine Protective Effect against Gastric Cancer Growth in Male BALB/c Mice

Cited by 9 publications

References 21 publications

The inhibition effects of Lentilactobacillus buchneri-derived membrane vesicles on AGS and HT-29 cancer cells by inducing cell apoptosis

The inhibition effects of Lentilactobacillus buchneri-derived membrane vesicles on AGS and HT-29 cancer cells by inducing cell apoptosis

The role of microbiomes in gastrointestinal cancers: new insights

Probiotics formulation and cancer nanovaccines show synergistic effect in immunotherapy and prevention of colon cancer

Contact Info

Product

Resources

About