Probiotic-enriched oily suspension in modulating skin microbiome and treating seborrheic dermatitis

Abstract

Seborrheic dermatitis (SD) affects 2-5% of the global population, with imbalances in the skin microbiome implicated in its development. This study assessed the impact of an oily suspension containing Lactobacillus crispatus P17631 and Lacticaseibacillus paracasei I1688 (termed EUTOPLAC) on SD symptoms and skin microbiome modulation. 25 SD patients were treated with EUTOPLAC for a week. Symptom severity and skin microbiome changes were measured at the start of the treatment (T0), after seven days (T8), and three weeks post-treatment (T28). Results indicated symptom improvement post-EUTOPLAC, with notable reductions in the Malassezia genus. Concurrently, bacterial shifts were observed, including a decrease in Staphylococcus and an increase in Lactobacillus and Lacticaseibacillus. Network analysis highlighted post-EUTOPLAC instability in fungal and bacterial interactions, with increased negative correlations between Malassezia and Lactobacillus and Lacticaseibacillus genera. The study suggests EUTOPLAC's potential as a targeted SD treatment, reducing symptoms and modulating the microbiome composition.

Role of Nutribiotics in Skin Care

“…Additionally, Di Domenico et al [229] assessed the impact of a topical oily suspension containing Lactobacillus crispatus P17631 and Lacticaseibacillus paracasei I1688 in patients affected by severe to moderate seborrheic dermatitis, finding that this mixture was able to reduce symptoms and modulate the microbiome composition, showing that topical administration of probiotics could also be useful in seborrheic dermatitis.…”