Probiotic Correction of Disorders of Liver Functions and Large Intestine Microecology in Chronic Viral Hepatitis

Abstract

the aim of the work was to study interrelations between blood activity and microbiocenosis of the large intestine in chronic viral hepatitis with the use of probiotic correction. Methods. To assess the condition of the liver and large intestine microbiocenosis, a case-control study of patients with CHB, CHC was conducted. Biochemical and microbiological parameters in patients with chronic hepatitis B and CHC have been compared with healthy individuals (the control group). For a comparative analysis of these samples’ differences, the Mann-Whitney test and Fisher test were used. Results. The liver disease of viral origin was manifested in 2-3times increase in activity of serum enzymes, microbiocenosis disorders of the large intestine (lower numbers of bifidobacteria - 10 6 CFU/g and lactobacilli - 10 3 CFU/g, 30 % increase of frequency of occurrence of S. aureus and reduction to 45 % of enterococci), and voltage mismatch intersystem links (links to the weakening of (τ = 0.26)). Conclusions. Use of probiotic preparations in treatment helps to restore the liver functions by means of increased functions of the large intestine microflora that is manifested in decreased activity of enzymes, increased content of representatives of obligate microflora up to physiological values and reduced frequency of occurrence of opportunistic pathogens, recovery of the interaction of the liver and the large intestine microbiocenosis (strengthening ties to (t = 0.56)).