Probiotic Characterization of Lactobacillus paracasei subsp. paracasei KNI9 Inhibiting Adherence of Yersinia enterocolitica on Caco-2 Cells In Vitro

Damodharan, Karthiyaini; Palaniyandi, Sasikumar Arunachalam; Suh, Joo‐Won; Yang, Seung Hwan

doi:10.1007/s12602-019-09535-8

Cited by 12 publications

(12 citation statements)

References 36 publications

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“…Lastly, we are under investigation whether fermented cpkimchi can afford probiotic-induced O-linked b-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) supported with publication by Hirata et al (48) that O-GlcNAcylation prevented colon carcinogenesis through reducing acute maximum inflammation in O-GlcNAc transferase-transgenic (Ogt-Tg) mice and some strain of probiotics can modify Ogt. (49) Our current investigation consistently showed dietary intake of fermented and special recipe kimchi, cpkimchi, can be ideal way for prevention of colitic cancer. While we studied the timing of cpkimchi administration in separate experiment, though coincidental intake of cpkimchi also showed significant suppression of colitic cancer, the best outcome was noted in group with preemptive intake of cpkimchi.…”

Section: Discussionsupporting

confidence: 62%

“…Lastly, we are under investigation whether fermented cpkimchi can afford probiotic-induced O -linked β- N -acetylglucosamine ( O -GlcNAc) modification ( O -GlcNAcylation) supported with publication by Hirata et al ( 48 ) that O -GlcNAcylation prevented colon carcinogenesis through reducing acute maximum inflammation in O -GlcNAc transferase-transgenic ( Ogt -Tg) mice and some strain of probiotics can modify Ogt. ( 49 )…”

Section: Discussionmentioning

confidence: 99%

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Dietary intake of fermented kimchi prevented colitis-associated cancer

Han

Kang

Park

et al. 2020

J. Clin. Biochem. Nutr.

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Kimchi is composed of various chemopreventive phytochemicals and profuse probiotics, defining kimchi as probiotic foods. Concerns had increased on the modulation of intestinal microbiota on various kinds of systemic diseases. Under the hypothesis that dietary intake of kimchi can be ideal intervention for either ameliorating colitis or preventing colitic cancer, we performed the study to validate the efficolitic cancery of fermented kimchi on preventing colitic cancer. Using azoxymethane-initiated and dextran sulfate sodium-promoted colitic cancer models, we have administrated fermented or non-fermented kimchi to modulate colitic cancer preemptively. Detailed molecular mechanisms were explored. Preemptive administration of fermented kimchi significantly afforded colitic cancer prevention through attenuating inflammasomes (IL-18, IL-1β, caspase-1), enhancing antioxidative (NQO1, GST-π), imposing anti-proliferative (Bax, caspase-3, β-catenin), and affording cytoprotective actions (HSP70, 15-PGDH), while non-fermented kimchi did not prevent colitic cancer. Special recipe cancer preventive kimchi (cpkimchi) was more effective compared to standard recipe fermented kimchi ( p <0.01), while non-fermented kimchi (kimuchi) worsened colitic cancer development, telling the importance of fermentation in cancer prevention. Repression of NF-kB p65, induction of tumor suppressive 15-PGDH, and inactivation of ERK1/2 by cpkimchi contributed to colitic cancer prevention. Dietary intake of cpkimchi ameliorated colitis and prevented colitic cancer via concerted anti-inflammatory, antioxidative, and anti-mutagenic actions.

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Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Dietary intake of fermented kimchi prevented colitis-associated cancer

Han

Kang

Park

et al. 2020

J. Clin. Biochem. Nutr.

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“…Damodharan et al reported L. paracasei produced both D-and L-lactate, which could be the reason for the broad-spectrum antimicrobial activity against enteropathogens. L. paracasei also showed high inhibition of pathogen adherence by competition and exclusion [42]. L. salivarius may influence immune regulation by increased induction of interleukin-10 (IL-10) [43], an anti-inflammatory cytokine, and reduced secretion of proinflammatory cytokines, such as tumor necrosis factor (TNF) alpha, IL-12, and interferon (IFN) gamma [44].…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of New Lactobacilli Probiotics for Unconstipated Irritable Bowel Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial

Jang

Kang

et al. 2019

Nutrients

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Irritable bowel syndrome (IBS) is a common and chronic gastrointestinal disorder. Probiotics may have the potential to impact the management of IBS; however, the results of trials are conflicting. This study aimed to investigate whether a mixture of lactobacilli probiotics could improve abdominal symptoms in patients with unconstipated IBS. Fifty Vietnamese patients with unconstipated IBS were randomly assigned to either the probiotics or placebo groups. During the intervention, participants took the probiotic supplement, named Foodis Lactobacillus, or placebo capsule once a day. Patients recorded their subject global assessment (SGA) weekly and were assessed with the visual analogue scale (VAS) during the 4-week study period. Patients with SGA score of 2 points or more or a decrease of more than 30% in VAS score were considered responders. Patients who responded weekly for more than 2 of the 4 weeks were considered overall responders. There was no significant difference in demographic characteristics between the groups. Overall responder rates of improvement of global IBS symptoms assessed by SGA score were significantly higher in the probiotics group (80.8%) than in the placebo group (45.8%) (p = 0.009). The overall responder rates assessed by VAS score were also higher in the probiotics group (69.2%, 41.7%, p = 0.048). There were no adverse events in either group during the study period. Our findings suggest that the new combination of Lactobacilli appears to be promising in the relief of abdominal symptoms in Vietnamese patients with unconstipated IBS.

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“…pentosaceus AOA2017-fermented soybean product . Importantly, the prerequisite for these beneficial effects was that LAB can tolerate harsh gastrointestinal (GIT) conditions and adhere to the intestinal mucosa for colonization in the intestinal tract . Previous research showed that P.…”

Section: Introductionmentioning

confidence: 99%

Pediococcus pentosaceus PP04 Ameliorates High-Fat Diet-Induced Hyperlipidemia by Regulating Lipid Metabolism in C57BL/6N Mice

Wang

You

Tian

et al. 2020

J. Agric. Food Chem.

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In this study, Pediococcus pentococcus PP04 isolated from the Northeast pickled cabbage had good gastrointestinal tolerance and can colonize in the intestine stably. C57BL/6N mice were fed a high-fat diet to build animal models and treated with Pediococcus pentosaceus PP04 to evaluate the antihyperlipidemia effect. After 8 weeks, the indicators of hyperlipidemia, liver injury, and inflammation were measured. The treatment of P. pentosaceus PP04 reduced the gain of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), free fatty acids (FFAs), leptin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), lipopolysaccharides (LPS), and tumor necrosis factor-α (TNF-α) significantly. The western blotting results suggested P. pentosaceus PP04 ameliorated high-fat diet-induced hyperlipidemia by the AMPK signaling pathway, which stimulated lipolysis via upregulation of PPARα and inhibited lipogenesis by downregulation of SREBP-1c, fatty acid synthase (FAS), and stearoyl-CoA desaturase-1 (SCD1) mainly. Furthermore, P. pentosaceus PP04 improved high-fat diet-induced oxidative stress effectively by triggering the Nrf2/CYP2E1 signaling pathway that enhanced the antioxidant activity including superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px).

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Probiotic Characterization of Lactobacillus paracasei subsp. paracasei KNI9 Inhibiting Adherence of Yersinia enterocolitica on Caco-2 Cells In Vitro

Cited by 12 publications

References 36 publications

Dietary intake of fermented kimchi prevented colitis-associated cancer

Dietary intake of fermented kimchi prevented colitis-associated cancer

Efficacy and Safety of New Lactobacilli Probiotics for Unconstipated Irritable Bowel Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial

Pediococcus pentosaceus PP04 Ameliorates High-Fat Diet-Induced Hyperlipidemia by Regulating Lipid Metabolism in C57BL/6N Mice

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