Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome

Sánchez, María Inés Pinto; Hall, Geoffrey B.; Ghajar, Kathy; Nardelli, Andrea; Bolino, Carolina; Lau, Jennifer T.; Martin, François‐Pierre J.; Cominetti, Ornella; Welsh, Chris; Rieder, Amber D.; Traynor, Jenna; Gregory, Caitlin; Palma, Giada De; Pigrau, Marc; Ford, Alexander C; Macri, Joseph; Berger, Bernard; Bergonzelli, Gabriela; Surette, Michael G.; Collins, Stephen M.; Martin, Paul; Berčík, Přemysl

doi:10.1053/j.gastro.2017.05.003

Cited by 601 publications

(569 citation statements)

References 60 publications

(11 reference statements)

Supporting

Mentioning

493

Contrasting

Unclassified

Order By: Relevance

“…Some studies have suggested that the gut microbiota is modified by probiotic supplementation, and can significantly decrease anxiety scores and improve anxiety disorders. Maria Ines PS, et al showed that one probiotic (named BL) can reduce anxiety scores and increase the quality of life in patients with IBS [33]. However, other studies have shown opposite results.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of Probiotics on Anxiety: A Meta-analysis of Randomized Controlled Trials

Huang¹,

Ning²,

Yang³

et al. 2017

Neuropsychiatry

View full text Add to dashboard Cite

Objective:Anxiety is a common, burdensome, and psychologically important global concern. However, probiotics may be useful for the treatment of anxiety. Methods:To assess the effects of probiotics on anxiety, seven academic databases were searched for reports published in the English language. Results:Based on our search, 10 studies were identified. Probiotics significantly decreased anxiety compared to controls (mean difference [MD], 0.66; 95% confidence interval [CI], 0.41 to 0.92; P < 0.001). However, significantly lower DASS values were reported of -9.87 (95%CI, -17.2 to -2.47; P < 0.009). Conclusions:Our report showed that probiotics decrease anxiety values in populations with anxiety. These results are important for the management of anxiety. In the future, more adequately powered RCTs using standardized measurements are required to assess the specific probiotics and dosages as well as the treatment periods that are most beneficial for anxiety.

show abstract

Section: Discussionmentioning

confidence: 99%

“…In our initial search, 128 articles were examined. Eventually, 10 studies [20,[28][29][30][31][32][33][34][35][36] involving 660 human subjects were identified that fulfilled the selection criteria (Table 1). One study used two scales for assessment, and we included both sets of subjects into the total numbers [34].…”

Section: Included Studiesmentioning

confidence: 99%

Efficacy of Probiotics on Anxiety: A Meta-analysis of Randomized Controlled Trials

Huang¹,

Ning²,

Yang³

et al. 2017

Neuropsychiatry

View full text Add to dashboard Cite

show abstract

“…Intake of Bifidobacterium longum did reduce depression and increase quality of life, but did not reduce anxiety in subjects with irritable bowel syndrome [22]. However, in another study, administration of the prebiotic trans-galactooligosaccharide, which promotes the growth of Lactobacilli, did result in decreased scores on the anxiety subscale of the Hospital Anxiety and Depression scale (HADS-A) [23].…”

Section: Discussionmentioning

confidence: 91%

Gut Microbiota and Anxiety: An Exploration of Key Findings

Ding¹

2017

J Depress Anxiety

View full text Add to dashboard Cite

“…Regarding the role of the microbiome-gut-brain axis in IBS (reviewed in 124 and 125 ), probiotic therapy has been shown to modulate CNS function in healthy volunteers 126 through effects on brain regions controlling processing of emotion and sensation. More recently, in a recent placebo controlled trial in IBS patients, treatment with the probiotic B. longum NCC3001 was associated with improved symptoms of depression and changes in brain activation patterns measured by functional magnetic resonance imaging 127 .…”

Section: Functional Gi Disordersmentioning

confidence: 99%

The Gut Microbiome in Adult and Pediatric Functional Gastrointestinal Disorders

Shin

Preidis

Shulman

et al. 2019

Clinical Gastroenterology and Hepatology

128

View full text Add to dashboard Cite

The importance of gut microbiota in gastrointestinal (GI) physiology was well described, but our ability to study gut microbial ecosystems in their entirety was limited by culture-based methods prior to the sequencing revolution. The advent of high-throughput sequencing opened new avenues, allowing us to study gut microbial communities as an aggregate, independent of our ability to culture individual microbes. Early studies focused on association of changes in gut microbiota with different disease states, which was necessary to identify a potential role for microbes and generate novel hypotheses. Over the past few years the field has moved beyond associations to better understand the mechanistic implications of the microbiome in the pathophysiology of complex diseases. This movement also has resulted in a shift in our focus toward therapeutic strategies, which rely on better understanding the mediators of gut microbiota-host cross-talk. It is not surprising the gut microbiome has been implicated in the pathogenesis of functional gastrointestinal disorders given its role in modulating physiological processes such as immune development, GI motility and secretion, epithelial barrier integrity, and brain-gut communication. In this review, we focus on the current state of knowledge and future directions in microbiome research as it pertains to functional gastrointestinal disorders. We summarize the factors that help shape the gut microbiome in human beings. We discuss data from animal models and human studies to highlight existing paradigms regarding the mechanisms underlying microbiota-mediated alterations in physiological processes and their relevance in human interventions. While translation of microbiome science is still in its infancy, the outlook is optimistic and we are advancing in the right direction toward precise mechanism-based microbiota therapies.

show abstract

Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome

Cited by 601 publications

References 60 publications

Efficacy of Probiotics on Anxiety: A Meta-analysis of Randomized Controlled Trials

Efficacy of Probiotics on Anxiety: A Meta-analysis of Randomized Controlled Trials

Gut Microbiota and Anxiety: An Exploration of Key Findings

The Gut Microbiome in Adult and Pediatric Functional Gastrointestinal Disorders

Contact Info

Product

Resources

About