Probiotic Bifidobacterium longum alters gut luminal metabolism through modification of the gut microbial community

Sugahara, Hirosuke; Odamaki, Toshitaka; Fukuda, Shinji; Kato, Tamotsu; Xiao, Jin‐zhong; Abe, Fumiaki; Kikuchi, Jun; Ohno, Hiroshi

doi:10.1038/srep13548

Cited by 134 publications

(82 citation statements)

References 55 publications

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“…This was consistent with changes we had previously observed in the Ang II-infusion hypertensive rodent model 22 . Furthermore, we observed a significant decrease in the Bifidobacterium genus and the related Bifidobacteriaceae family of Actinobacteria phyla (Figure 6C, in green), a gram-positive bacterium with probiotic properties 35, 36 . We also observed a decrease in several bacterial genera of the Bacteroidetes phyla.…”

Section: Resultsmentioning

confidence: 94%

Hypertension-Linked Pathophysiological Alterations in the Gut

Santisteban¹,

Qi²,

Zubcevic³

et al. 2017

Circulation Research

390

421

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Rationale Sympathetic nervous system control of inflammation plays a central role in hypertension. The gut receives significant sympathetic innervation, is densely populated with a diverse microbial ecosystem, and contains immune cells that greatly impact overall inflammatory homeostasis. Despite this uniqueness, little is known about the involvement of the gut in hypertension. Objective Test the hypothesis that increased sympathetic drive to the gut is associated with increased gut wall permeability, increased inflammatory status, and microbial dysbiosis and that these gut pathological changes are linked to hypertension. Methods and Results Gut epithelial integrity and wall pathology were examined in spontaneously hypertensive rat (SHR) and chronic Angiotensin II infusion rat models. The increase in blood pressure in SHR was associated with gut pathology that included increased intestinal permeability and decreased tight junction proteins. These changes in gut pathology in hypertension were associated with alterations in microbial communities relevant in blood pressure control. We also observed enhanced gut-neuronal communication in hypertension originating from paraventricular nucleus of the hypothalamus and presenting as increased sympathetic drive to the gut. Finally, angiotensin converting enzyme inhibition (captopril) normalized blood pressure and was associated with reversal of gut pathology. Conclusions A dysfunctional sympathetic-gut communication is associated with gut pathology, dysbiosis, and inflammation, and plays a key role in hypertension. Thus, targeting of gut microbiota by innovative probiotics, antibiotics, and fecal transplant, in combination with current pharmacotherapy, may be a novel strategy for hypertension treatment.

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Section: Resultsmentioning

confidence: 94%

Hypertension-Linked Pathophysiological Alterations in the Gut

Santisteban¹,

Qi²,

Zubcevic³

et al. 2017

Circulation Research

390

421

View full text Add to dashboard Cite

show abstract

“…For instance, one study included species that are able to break down complex dietary polysaccharides not accessible to the host (B. thetaiotaomicron, Bacteroides ovatus, and Bacteroides caccae), to consume oligosaccharides and simple sugars (Eubacterium rectale, Marvinbryantia formatexigens, Collinsella aerofaciens, and E. coli), to ferment amino acids (Clostridium symbiosum and E. coli), or to remove the end products of fermentation by reducing sulfate (Desulfovibrio piger) or generating acetate (Blautia hydrogenotrophica) (41). This community has been frequently exploited to study hostmicrobe interactions or microbe-microbe interactions by the same research group or adopted by others albeit in different combinations ranging from 8 to 15 species (40,42,(44)(45)(46)(47)(48)(49)(50). Recently, a more diverse, complex defined community comprising no fewer than 92 species was developed (51).…”

Section: Toward a Normal Model Gut Microbiotamentioning

confidence: 99%

The Use of Defined Microbial Communities To Model Host-Microbe Interactions in the Human Gut

Elzinga

Oost

Vos

et al. 2019

Microbiol Mol Biol Rev

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SUMMARYThe human intestinal ecosystem is characterized by a complex interplay between different microorganisms and the host. The high variation within the human population further complicates the quest toward an adequate understanding of this complex system that is so relevant to human health and well-being. To study host-microbe interactions, defined synthetic bacterial communities have been introduced in gnotobiotic animals or in sophisticatedin vitrocell models. This review reinforces that our limited understanding has often hampered the appropriate design of defined communities that represent the human gut microbiota. On top of this, some communities have been applied toin vivomodels that differ appreciably from the human host. In this review, the advantages and disadvantages of using defined microbial communities are outlined, and suggestions for future improvement of host-microbe interaction models are provided. With respect to the host, technological advances, such as the development of a gut-on-a-chip system and intestinal organoids, may contribute to more-accuratein vitromodels of the human host. With respect to the microbiota, due to the increasing availability of representative cultured isolates and their genomic sequences, our understanding and controllability of the human gut “core microbiota” are likely to increase. Taken together, these advancements could further unravel the molecular mechanisms underlying the human gut microbiota superorganism. Such a gain of insight would provide a solid basis for the improvement of pre-, pro-, and synbiotics as well as the development of new therapeutic microbes.

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“…Many strains produce bacteriocins, namely lactacin and bisin that inhibit the growth of pathogenic bacteria [52][53][54]. Specific strains may modulate gut inflammation lowering the levels of pro-inflammatory biomarkers, such as IL-1β and C-reactive protein and increasing middle molecules, such as IL-6 and TNF-α, that up-regulate the levels of anti-inflammatory markers like IL-10 [55][56][57][58][59].…”

Section: Probioticsmentioning

confidence: 99%

Reality of "Enteric Dialysis ®" with Probiotics and Prebiotics to Delay the Need of Conventional Dialysis

Ranganathan¹

2018

J Nephrol Ther

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Probiotics and prebiotics are generally used for gut, immune and digestive health. However, we have been looking outside the box for the use of probiotics and prebiotics toward help in maintaining healthy kidney function. The gut microbiome is unfavorably altered (i.e., dysbiosis) in individuals with renal impairment, promoting progressive renal failure, persistent systemic inflammation, and small bowel bacterial overgrowth (SBBO). A probiotic that delays the progression of kidney failure would have enormous impact as millions of individuals worldwide suffer from chronic kidney disease and, not all individuals; especially in low income countries have access to chronic dialysis care. Probiotics have demonstrated their ability to remove uremic toxins, and early studies indicate the slowing of renal disease progression. The role of probiotics in managing renal failure is not yet clearly defined, but the data thus far, suggest that probiotics will prove to play a significant role in chronic kidney disease management.

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Probiotic Bifidobacterium longum alters gut luminal metabolism through modification of the gut microbial community

Cited by 134 publications

References 55 publications

Hypertension-Linked Pathophysiological Alterations in the Gut

Hypertension-Linked Pathophysiological Alterations in the Gut

The Use of Defined Microbial Communities To Model Host-Microbe Interactions in the Human Gut

Reality of "Enteric Dialysis ®" with Probiotics and Prebiotics to Delay the Need of Conventional Dialysis

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