Probiotic bacteria reduced duration and severity but not the incidence of common cold episodes in a double blind, randomized, controlled trial

Vrese, Michael de; Winkler, Petra; Rautenberg, Peter; Harder, Timm C.; Noah, Christian; Laue, Christiane; Ott, Stephan; Hampe, Jochen; Schreiber, Stefan; Heller, Knut J.; Schrezenmeir, Jürgen

doi:10.1016/j.vaccine.2006.05.048

Cited by 172 publications

(124 citation statements)

References 20 publications

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“…The results indicate a reduction in the duration of episodes of common cold of at least 2 days and a decrease in the severity of symptoms among subjects receiving probiotics if compared to the randomized placebo-control group [92]. Similar conclusions were obtained in a study that assessed the effect of long-term intake of probiotics on the same pathology [93]. Another, double-blind, randomized, placebo-controlled trial, performed on 237, 234, and 250 healthy adults investigated, in three winter seasons, the efficacy of different probiotics in restoring and maintaining intestinal balance and the potential protection from respiratory tract infections [94].…”

Section: Adultssupporting

confidence: 75%

Probiotics and health: An evidence-based review

Aureli

Capurso

Castellazzi

et al. 2011

Pharmacological Research

232

131

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a b s t r a c tThe intestinal microbiota is an ecosystem formed by a variety of ecological niches, made of several bacterial species and a very large amount of strains. The microbiota is in close contact with the intestinal mucosa or epithelial interface which is, after the respiratory area, the largest surface of the body, occupying approximately 250-400 m 2 . The physiological activities of the microbiota are manifold and are just being unraveled. Based on the observations of the multiple roles played by the microbiota in health and disease, the notion of modifying it with appropriate formulations, i.e. probiotics, is being tested in several settings.This review summarizes the current knowledge on probiotics and discusses both limitations and acquired evidence to support their use in preventive and therapeutic medicine.

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Section: Adultssupporting

confidence: 75%

Probiotics and health: An evidence-based review

Aureli

Capurso

Castellazzi

et al. 2011

Pharmacological Research

232

131

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“…A better precise immune response to a Salmonella typhi oral vaccine has been described in persons consuming a probiotic containing Lactobacillus johnsonii and Bifidobacterium lactis [145], and Lactobacillus fermentum showed positive results for influenza [146]. Probiotics containing Lactobacillus gasseri, Bifidobacterium longum, and Bifidobacterium bifidum concise the duration of common cold and reduced fever [147]. Irritable bowel syndrome, one of the most common disorders seen by primary care physicians, affects 7-10% of the world population.…”

Section: Beneficial Microbes For Human Healthmentioning

confidence: 99%

Beneficial microbiomes: Biodiversity and potential biotechnological applications for sustainable agriculture and human health

Yadav¹,

Kumar²,

Kumar³

et al. 2017

J App Biol Biotech

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The beneficial microbes plays an important role in medical, industrial, and agricultural processes. The precious microbes belong to different groups including archaea, bacteria, and fungi which can be sort out from different habitat such as extreme environments (acidic, alkaline, drought, pressure, salinity, and temperatures) and associated with plants (epiphytic, endophytic, and rhizospheric) and human. The beneficial microbes exhibited multifunctional plant growth promoting (PGP) attributes such as N 2 -fixation, solubilization of micronutrients (phosphorus, potassium and zinc), and production of siderophores, antagonistic substances, antibiotic, auxin, and gibberellins. These microbes could be applied as biofertilizers for native as well as crops growing at diverse extreme habitat. Microbes with PGP attributes of N 2 -fixation, P-, and K-solubilization could be used at a place of NPK chemical fertilizers. Agriculturally, important microbes with Fe-and Zn-solubilizing attributes can be used for biofortification of micronutrients in different cereal crops. The biofertilizers are an eco-friendly technology and bioresources for sustainable agriculture and human health. In general, the concentrations of micronutrient in different crops are not adequate for human nutrition in diets. Hence, consumption of such cereal-based diet may result in micronutrient malnutrition and related severe health complications. The biofortification approach is getting much attention to increase the availability of micronutrients, especially Fe and Zn in the major food crops. The beneficial microbes can be used as probiotic as functional foods for human health. Probiotics microbes such as Bifidobacterium, Lactobacillus, Methanobrevibacter, Methanosphaera, and Saccharomyces are increasingly being used as dietary supplements in functional food products. The microbes with beneficial properties could be utilized for sustainable agriculture and human health.

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“…Probiotic bacteria may reduce the incidence and/or severity of respiratory infections in children (67) , adults (68) Fig. 3.…”

Section: Probiotics and Respiratory Infectionsmentioning

confidence: 99%

Ageing, immunity and influenza: a role for probiotics?

Yaqoob

2013

Proc. Nutr. Soc.

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Influenza is a major cause of death in the over 65s. Increased susceptibility to infection and reduced response to vaccination are due to immunosenscence in combination with medical history and lifestyle factors. Age-related alterations in the composition of the gut microbiota have a direct impact on the immune system and it is proposed that modulation of the gut microbiota using pre- and probiotics could offer an opportunity to improve immune responses to infections and vaccination in older people. There is growing evidence that probiotics have immunomodulatory properties, which to some extent are strain-dependent, and are strongly influenced by ageing. Randomised controlled trials suggest that probiotics may reduce the incidence and/or severity of respiratory infections, although there is limited data on older people. A small number of studies have examined the potential adjuvant effects of selected probiotics for vaccination against influenza; however, the data is inconsistent, particularly in older people. This review describes the impact of age-related changes in the gut on the immune response to respiratory infections and evaluates whether restoration of gut microbial homoeostasis by probiotics offers an opportunity to modulate the outcome of respiratory infections and vaccination against influenza in older people. Although there is promising evidence for effects of probiotics on human health, there is a lack of consistent data, perhaps partly due to strain-specific differences and an influence of the age of the host. Further research is critical in evaluating the potential use of probiotics in respiratory infections and vaccination in the ageing population.

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Probiotic bacteria reduced duration and severity but not the incidence of common cold episodes in a double blind, randomized, controlled trial

Cited by 172 publications

References 20 publications

Probiotics and health: An evidence-based review

Probiotics and health: An evidence-based review

Beneficial microbiomes: Biodiversity and potential biotechnological applications for sustainable agriculture and human health

Ageing, immunity and influenza: a role for probiotics?

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