Probiotic bacteria in cancer patients undergoing chemotherapy and radiation therapy

Mego, Michal; Holec, V; Drgoňa, Ľuboš; Hainova, Katarina; Ciernikova, Sona; Zajac, Vladimír

doi:10.1016/j.ctim.2013.08.018

Cited by 80 publications

(41 citation statements)

References 78 publications

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“…are not yet sufficiently conclusive to recommend the use of prebiotics; nevertheless, their administration may help improve cancer treatment. Concurrent administration of prebiotics and probiotics may prevent adverse effects from oncology treatments, particularly from pelvic radiotherapy 41 .…”

Section: Randomized Clinical Trialsmentioning

confidence: 99%

“…There is concern about the administration of probiotics in cancer patients, on account of the risk of infection and the transfer of antibiotic resistance. That said, randomized clinical trials have not reported a significant increase in the risk of developing adverse effects following probiotic supplementation, when compared to patients who received placebo; on the contrary, probiotics have been proven safe and beneficial in these patients 41 .…”

Section: Randomized Clinical Trialsmentioning

confidence: 99%

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Use of Functional Foods and Oral Supplements as Adjuvants in Cancer Treatment

Serna-Thomé

Castro-Eguiluz

Fuchs-Tarlovsky

et al. 2018

RIC

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In cancer patients treated with radiotherapy to the abdominopelvic region, dietary modifications and the use of functional foods (fortified food with added ingredients to provide specific health improving benefits, such as antioxidants, omega-3 fatty acids, and glutamine), may contribute to the improvement of the toxic effects of treatment, including nausea, diarrhea, and constipation, among others. With the aim of analyzing which coadjuvant foods benefit these patients, scientific evidence was gathered by a group of experts. For these patients, the authors recommend a diet that includes sufficient foods rich in antioxidants and polyphenols instead of supplements. Docosahexaenoic and eicosapentaenoic acids have proven useful for the management of anorexia/cachexia in pancreatic cancer patients. Probiotics composed of Lactobacillus spp. and Bifidobacterium spp. are regarded as safe even in patients with neutropenia and have been proven to decrease gastrointestinal symptoms. Several factors should be considered before probiotic supplementation, these include the stage of the disease, radiation dose, and symptomatology of each patient. There is no demonstrated clear benefit to the use of glutamine, so it is not recommended due to its high cost.

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Section: Randomized Clinical Trialsmentioning

confidence: 99%

Section: Randomized Clinical Trialsmentioning

confidence: 99%

Use of Functional Foods and Oral Supplements as Adjuvants in Cancer Treatment

Serna-Thomé

Castro-Eguiluz

Fuchs-Tarlovsky

et al. 2018

RIC

View full text Add to dashboard Cite

show abstract

“…It is well known that due to immunosuppression, neutropenia poses a risk of infectious disease occurring during treatment. In addition, chemotherapy is responsible for gastrointestinal toxicity because of mucosal damage, and altering the natural host microflora . It should be noted that tumor cells that remain after chemotherapy frequently show increased aggressiveness, and can enter blood and lymph vessels, thereby increasing the probability of metastasis .…”

Section: Combination Of Bacteriotherapy With Chemotherapymentioning

confidence: 99%

“…Whitford et al, showed that Streptococcus thermophilus has beneficial effects on 5‐fluorouracil (5‐FU) complications (intestinal mucositis) . Bowen et al suggested that, in spite of the overall shortage of hard data, probiotics should be tested for chemotherapy complications . In another investigation, 150 patients with colorectal cancer receiving 5‐FU and leucovorin bolus injections plus continuous 5‐FU infusion as postoperative adjuvant therapy, were randomly allocated to receive L rhamnosus GG (1‐2 × 10(10) CFU) and fiber (11 g guar gum) per day, while others did not.…”

Section: Combination Of Bacteriotherapy With Chemotherapymentioning

confidence: 99%

Therapeutic bacteria to combat cancer; current advances, challenges, and opportunities

et al. 2019

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Successful treatment of cancer remains a challenge, due to the unique pathophysiology of solid tumors, and the predictable emergence of resistance. Traditional methods for cancer therapy including radiotherapy, chemotherapy, and immunotherapy all have their own limitations. A novel approach is bacteriotherapy, either used alone, or in combination with conventional methods, has shown a positive effect on regression of tumors and inhibition of metastasis. Bacteria‐assisted tumor‐targeted therapy used as therapeutic/gene/drug delivery vehicles has great promise in the treatment of tumors. The use of bacteria only, or in combination with conventional methods was found to be effective in some experimental models of cancer (tumor regression and increased survival rate). In this article, we reviewed the major advantages, challenges, and prospective directions for combinations of bacteria with conventional methods for tumor therapy.

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“…33 The beneficial effects of probiotic as radioprotectors have obtained from studies that used probiotic to preserve gastrointestinal tract in different radiotherapy patients. 34,35 Probiotics, also have different abilities such as antioxidant property, toxin neutralization, antagonistic activity, synergistic activity, and stimulation of the immune system 36 (Kanmani et al, 2013).…”

Section: Biological Systems Probioticsmentioning

confidence: 99%

Radiation protection and secondary cancer prevention using biological radioprotectors in radiotherapy

Abdollahi

Shiri

Atashzar

et al. 2015

Int J Cancer Ther Oncol

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Radiotherapy is the feasible treatment approach for many malignant diseases and cancers. New radiotherapy techniques such as ion therapy, stereotactic radiosurgery and intensity modulated radiation therapy deliver higher low dose radiation to large volume of normal tissues and are in debating as more secondary cancers inducers. A secondary cancer after radiotherapy is an important issue that reduces treatment efficiency and should be decreased. Radioprotective compounds are of importance in clinical radiation therapy for saving normal tissues. In the present study, we are so interest to introduce, suggest and review the application of biological radioprotectors in radiotherapy. We propose probiotics, prebiotics, gas, vitamin and nanoparticle producing microorganisms as new biological systems based radioprotectors to protect normal tissues. Also, we reviewed the main biological pathways, molecules and also radioadaptive response that act as radioprotectors. In this review we tried to address the secondary cancer induction by radiotherapy and also main biological radiation protection approaches, although there is a wealth of data in this subject.

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Probiotic bacteria in cancer patients undergoing chemotherapy and radiation therapy

Abstract: Current evidence supporting probiotic use as adjunctive therapy to anticancer treatment is limited, especially in cancer patients treated with chemotherapy. Well designed clinical trials are needed to find true role of probiotics in oncology.

Cited by 80 publications

References 78 publications

Use of Functional Foods and Oral Supplements as Adjuvants in Cancer Treatment

Use of Functional Foods and Oral Supplements as Adjuvants in Cancer Treatment

Therapeutic bacteria to combat cancer; current advances, challenges, and opportunities

Radiation protection and secondary cancer prevention using biological radioprotectors in radiotherapy

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