Probiotic bacteria attenuates cisplatin-induced nephrotoxicity through modulation of oxidative stress, inflammation and apoptosis in rats

Şengül, Emin; Gelen, Sevda Urçar; Yıldırım, Serkan; Çelebi, Fikret; Çınar, Ali

doi:10.4103/2221-1691.254605

Cited by 19 publications

(7 citation statements)

References 2 publications

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“…High doses of CYP cause acute cardiotoxicity, such as cardiac decompensation with fatal cardiomyopathy (1,6,7,19). Some antioxidant compounds are used to reduce oxidative stress and the possible side effects of anticancer drugs (2,(8)(9)(10)20). Naringin is one of the potent antioxidant compounds that are abundant in citrus fruits.…”

Section: Discussionmentioning

confidence: 99%

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Investigation of Protective Effects of Naringin on ECG, Cardiac Enzymes, Cardiac Histopathology and 8-OHdG Expression in Cyclophosphamide-Induced Cardiotoxicity in Rats

Kolikpinar¹,

Dağ²,

Tekin³

et al. 2021

Atatürk Üniversitesi Veteriner Bilimleri Dergisi

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Section: Discussionmentioning

confidence: 99%

“…to minimize the cytotoxic effects of antineoplastic drugs (8,9). One of the compounds used for this purpose is Naringin.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Protective Effects of Naringin on ECG, Cardiac Enzymes, Cardiac Histopathology and 8-OHdG Expression in Cyclophosphamide-Induced Cardiotoxicity in Rats

Kolikpinar¹,

Dağ²,

Tekin³

et al. 2021

Atatürk Üniversitesi Veteriner Bilimleri Dergisi

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“…The strains exerted immune-enhancing effects in the stimulation of RAW 264.7 cells, and showed higher cytokine production of inducible NO synthase (iNOS) and tumour necrosis factor-α (TNF-α), in comparison with non-stimulated control cells with LPS [ 129 ]. The protective effects of LAB on cisplatin (CP)-induced renal damage have been also observed and attributed to the anti-inflammatory and antioxidant properties of probiotics by decreasing oxidative stress, inflammation, apoptosis, DNA, and histopathological damage in rat kidney tissue [ 130 ].…”

Section: Applications To Human Healthmentioning

confidence: 99%

Synbiotics and Their Antioxidant Properties, Mechanisms, and Benefits on Human and Animal Health: A Narrative Review

et al. 2022

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Antioxidants are often associated with a variety of anti-aging compounds that can ensure human and animal health longevity. Foods and diet supplements from animals and plants are the common exogenous sources of antioxidants. However, microbial-based products, including probiotics and their derivatives, have been recognized for their antioxidant properties through numerous studies and clinical trials. While the number of publications on probiotic antioxidant capacities and action mechanisms is expanding, that of synbiotics combining probiotics with prebiotics is still emerging. Here, the antioxidant metabolites and properties of synbiotics, their modes of action, and their different effects on human and animal health are reviewed and discussed. Synbiotics can generate almost unlimited possibilities of antioxidant compounds, which may have superior performance compared to those of their components through additive or complementary effects, and especially by synergistic actions. Either combined with antioxidant prebiotics or not, probiotics can convert these substrates to generate antioxidant compounds with superior activities. Such synbiotic-based new routes for supplying natural antioxidants appear relevant and promising in human and animal health prevention and treatment. A better understanding of various component interactions within synbiotics is key to generating a higher quality, quantity, and bioavailability of antioxidants from these biotic sources.

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“…Various studies have shown that the use of some natural substances with anti-inflammatory properties can prevent inflammation-induced tissue damage [58][59][60][61][62][63][64][65]. Flavonoids are one of these natural ingredients.…”

Section: Flavonoids and Phenolic Compounds In Covid-19mentioning

confidence: 99%

Can Polyphenols be Used as Anti-Inflammatory Agents against Covid-19 (SARS-CoV-2)-Induced Inflammation?

Gelen¹,

Kükürt²,

Şengül³

et al. 2022

Phenolic Compounds - Chemistry, Synthesis, Diversity, Non-Conventional Industrial, Pharmaceutical and Therapeutic Applications

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Covid-19 is the causative agent of a beta coronavirus that causes severe inflammatory pneumonia, so excessive inflammation is considered a risk factor for the disease. In Covid-19 disease, an inflammatory response develops in the body. It has been reported as a result of various studies that this response causes damage to various organs and tissues, especially the lungs. According to reports, cytokine storms are largely responsible for death in such patients. Some of the consequences of severe inflammation and cytokine storms include acute respiratory distress syndrome, acute lung injury, and multiple organ dysfunction syndromes. Many studies are showing that there may be various agents to prevent or treat these effects of Covid-19 disease. Some of these agents are phenolic compounds. Phenolic compounds are the most abundant substances in vegetables and fruits. Inflammasomes, their function. It has been stated that phenolic compounds inhibit inflammation by inhibiting cytosolic multiprotein complexes that assemble in response to cytosolic pathogen-associated molecular patterns (PAMPs), and damage-associated molecular patterns (DAMPs) to form active forms of IL-1β and IL-18. It suggested that Apigenin, Resveratrol, Morin, and Silymarin an anti-inflammatory, antioxidant, anti-viral, and anti-microbial compound could be a potential therapeutic agent for severe inflammation from Covid-19.

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Probiotic bacteria attenuates cisplatin-induced nephrotoxicity through modulation of oxidative stress, inflammation and apoptosis in rats

Cited by 19 publications

References 2 publications

Investigation of Protective Effects of Naringin on ECG, Cardiac Enzymes, Cardiac Histopathology and 8-OHdG Expression in Cyclophosphamide-Induced Cardiotoxicity in Rats

Investigation of Protective Effects of Naringin on ECG, Cardiac Enzymes, Cardiac Histopathology and 8-OHdG Expression in Cyclophosphamide-Induced Cardiotoxicity in Rats

Synbiotics and Their Antioxidant Properties, Mechanisms, and Benefits on Human and Animal Health: A Narrative Review

Can Polyphenols be Used as Anti-Inflammatory Agents against Covid-19 (SARS-CoV-2)-Induced Inflammation?

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