Probiotic and metronidazole treatment for recurrent bacterial vaginosis

Thulkar, Jyoti; Kriplani, Alka; Agarwal, Nutan

doi:10.1016/j.ijgo.2009.09.029

Cited by 6 publications

(2 citation statements)

References 3 publications

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“…Secondary outcomes were as follows: incidence rates of adverse events (AE, defined as any untoward medical occurrence associated with the use of a drug, whether or not being considered drug-related [33]).…”

Section: Methodsmentioning

confidence: 99%

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Probiotics for the Treatment of Bacterial Vaginosis: A Meta-Analysis

Wang

Ying

2019

IJERPH

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Background: The effect of probiotic therapy on bacterial vaginosis (BV) is controversial. We conducted a meta-analysis of the efficacy and safety associated with probiotic treatment for BV. Methods: We searched multiple databases covering up to 1 March 2018. Studies published as blinded randomized controlled trials (RCTs), comparing treatment using probiotic versus active or placebo control in BV patients were included, with at least one-month follow-up. Random effects model and trial sequential analysis (TSA) were applied. Results: Ten studies (n = 2321) were included. Compared with placebo, the probiotics-only therapy resulted in a beneficial outcome both in clinical cure rate at the 30th day (risk ratio, RR = 2.57; 95% confidential interval, 95% CI: 1.96 to 3.37), and Nugent score (mean difference, MD = −2.71; 95% CI: −3.41 to −2.00). This effect decreased but remained significant after eight weeks. Probiotics-post-antibiotics therapy had a decreased effect only for a short term and possibly among studies with a mostly black study population. No extra adverse events were observed. The TSA suggested a larger sample size for effective evaluation of the probiotics as a supplementary remedy. Conclusions: Probiotic regimes are safe and may exhibit a short-term and long-term beneficial effect for BV treatment. The ethnic-specific result for the probiotic used after antibiotics is worthy of further study.

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Section: Methodsmentioning

confidence: 99%

“…We assessed heterogeneity using Cochran’s Q test [33] and Higgins’ I 2 statistic [34] for each meta-analysis. Higgins’ I 2 was used to classify the heterogeneity according to the reference (<25% = low; 25%–50% = moderate; 50%–75% = substantial; >75% = high).…”

Section: Methodsmentioning

confidence: 99%