Abstract:TRPV1 is a tetrameric voltage-sensitive cation channel that is activated by heat and vanilloids. The architecture of TRP channels are thought to be related to Kv channels, with each subunit containing six transmembrane segments. In addition to being activated by capsaicin, TRPV1 is activated by Double-Knot Toxin (DkTx), a protein toxin purified from the Chinese Bird Spider, Selenocosmia huwena (Bohlen et al. 2010, Cell 141, 834-35). DkTx is unique in that it contains two Inhibitor Cysteine Knots (ICK) motifs c… Show more
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