Probing the Thermal Transitions of Lactobionic Acid and Effects of Sample History by DSC Analysis

Mascia, L.; Coroli, Alessandro; Mele, Elisa

doi:10.1016/j.xphs.2019.09.017

Cited by 4 publications

(3 citation statements)

References 11 publications

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“…Vassileva and Friederich [149] have observed suppression in the β relaxations and an increase in T β with the incorporation of alumina nanoparticles into an amine cured epoxy resin, which they have attributed to an antiplasticization feature resulting from densification of the resin matrix around the dispersed nanoparticle. A similar effect on β relaxations created by the presence of a filler (insoluble high-surface energy component of a mixture) was recently observed by Mascia et al [150] in studies on the thermal transition by DSC analysis of lactobionic acid (organic molecular glass). The relaxation peak below the Tg was shifted to higher temperatures and became more pronounced through physical ageing, which can be taken as a confirmation that the antiplasticization effect observed in a "thermoset" polymer glass can be attributed to the presence of "free" low-MW species, as also indicated in the findings of Rasoldier et al [148].…”

Section: Polymer Matrix Composites and Nanocompositessupporting

confidence: 73%

Antiplasticization of Polymer Materials: Structural Aspects and Effects on Mechanical and Diffusion-Controlled Properties

et al. 2020

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Antiplasticization of glassy polymers, arising from the addition of small amounts of plasticizer, was examined to highlight the developments that have taken place over the last few decades, aiming to fill gaps of knowledge in the large number of disjointed publications. The analysis includes the role of polymer/plasticizer molecular interactions and the conditions leading to the cross-over from antiplasticization to plasticization. This was based on molecular dynamics considerations of thermal transitions and related relaxation spectra, alongside the deviation of free volumes from the additivity rule. Useful insights were gained from an analysis of data on molecular glasses, including the implications of the glass fragility concept. The effects of molecular packing resulting from antiplasticization are also discussed in the context of physical ageing. These include considerations on the effects on mechanical properties and diffusion-controlled behaviour. Some peculiar features of antiplasticization regarding changes in Tg were probed and the effects of water were examined, both as a single component and in combination with other plasticizers to illustrate the role of intermolecular forces. The analysis has also brought to light the shortcomings of existing theories for disregarding the dual cross-over from antiplasticization to plasticization with respect to modulus variation with temperature and for not addressing failure related properties, such as yielding, crazing and fracture toughness.

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Section: Polymer Matrix Composites and Nanocompositessupporting

confidence: 73%

Antiplasticization of Polymer Materials: Structural Aspects and Effects on Mechanical and Diffusion-Controlled Properties

et al. 2020

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“…The complexity of the thermal transitions exhibited by LBA has been discussed in our previous work [ 6 ], which established that the behavior is very sensitive to the thermal history of the sample. It was shown that the main glass transition of LBA started at around 122 °C, while another transition ( T β ), associated with β relaxations, occurred at around 75 °C, which was very sensitive to the moisture present in the sample.…”

Section: Resultsmentioning

confidence: 99%

“…It is composed of a galactose moiety linked to a gluconic acid molecule via an ether-like linkage. The high content and proximity of hydroxyl groups of the LBA molecule are largely responsible for the high solubility of LBA in water (free water); while the strong intermolecular attractions with COOH groups through H-bonds with water molecules (bond water) are likely to determine moisture retention characteristics up to a temperature higher than the boiling point of water and close to the glass transition temperature ( T g ) of LBA [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

An In-Vitro Evaluation of the Characteristics of Zein-Based Films for the Release of Lactobionic Acid and the Effects of Oleic Acid

et al. 2021

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Lactobionic acid (LBA) is widely used in different industrial sectors owing to its biocompatibility characteristics as well as antioxidant and antimicrobial properties. In this study, mixtures of the protein zein with LBA and with the addition of oleic acid (OA) as a ternary system were investigated as drug delivery films for the release of LBA. The chosen combinations exploit the vast difference in water solubility between LBA and the other two components (zein and OA). DSC thermograms and dynamic mechanical spectra, alongside electron microscopy images, were used to describe the microstructural features of the films and were found to provide insights for the release of LBA from the two examined zein-based films immersed in an aqueous physiological solution. For both film systems, a burst release behavior was observed, followed by a rapid and total extraction of LBA. The required immersion time for the total extraction of LBA was greatly reduced when oleic acid was added to the precursor solution mixture for producing the films. The LBA released from the zein-based films was found to exhibit both the expected antioxidant properties as well as exerting bacteriostatic effects towards Escherichia coli and Staphylococcus epidermidis.

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Apocynin-loaded PLGA nanomedicine tailored with galactosylated chitosan intrigue asialoglycoprotein receptor in hepatic carcinoma: Prospective targeted therapy

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Aman

Othman

et al. 2023

International Journal of Pharmaceutics

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Probing the Thermal Transitions of Lactobionic Acid and Effects of Sample History by DSC Analysis

Cited by 4 publications

References 11 publications

Antiplasticization of Polymer Materials: Structural Aspects and Effects on Mechanical and Diffusion-Controlled Properties

Antiplasticization of Polymer Materials: Structural Aspects and Effects on Mechanical and Diffusion-Controlled Properties

An In-Vitro Evaluation of the Characteristics of Zein-Based Films for the Release of Lactobionic Acid and the Effects of Oleic Acid

Apocynin-loaded PLGA nanomedicine tailored with galactosylated chitosan intrigue asialoglycoprotein receptor in hepatic carcinoma: Prospective targeted therapy

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