Probing the potential of mucus permeability to signify preterm birth risk

Smith-Dupont, Kathryn B.; Wagner, Caroline E.; Witten, Jacob; Conroy, Kelley; Rudoltz, H.; Pagidas, Kelly; Snegovskikh, Victoria; House, Michael; Ribbeck, Katharina

doi:10.1038/s41598-017-08057-z

Cited by 29 publications

(39 citation statements)

References 59 publications

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“…When the structure and composition of the mucus layer are aberrant, infections are likely to arise (Goldenberg et al, 2000). During pregnancy, this can be linked to preterm birth (Smith-Dupont et al, 2017). The tightness of the barrier as composed by in vitro cultured epithelial cells, can be quantified using transepithelial electrical resistance (TEER) (Gorodeski, 1996;Srinivasan B. et al, 2015).…”

Section: Fatty Acid Metabolites Affect the Epithelial Barrier Functionmentioning

confidence: 99%

The Role of Fatty Acid Metabolites in Vaginal Health and Disease: Application to Candidiasis

et al. 2021

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Although the vast majority of women encounters at least one vaginal infection during their life, the amount of microbiome-related research performed in this area lags behind compared to alternative niches such as the intestinal tract. As a result, effective means of diagnosis and treatment, especially of recurrent infections, are limited. The role of the metabolome in vaginal health is largely elusive. It has been shown that lactate produced by the numerous lactobacilli present promotes health by limiting the chance of infection. Short chain fatty acids (SCFA) have been mainly linked to dysbiosis, although the causality of this relationship is still under debate. In this review, we aim to bring together information on the role of the vaginal metabolome and microbiome in infections caused by Candida. Vulvovaginal candidiasis affects near to 70% of all women at least once in their life with a significant proportion of women suffering from the recurrent variant. We assess the role of fatty acid metabolites, mainly SCFA and lactate, in onset of infection and virulence of the fungal pathogen. In addition, we pinpoint where lack of research limits our understanding of the molecular processes involved and restricts the possibility of developing novel treatment strategies.

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Section: Fatty Acid Metabolites Affect the Epithelial Barrier Functionmentioning

confidence: 99%

The Role of Fatty Acid Metabolites in Vaginal Health and Disease: Application to Candidiasis

et al. 2021

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“…Microorganisms identified in the amniotic fluid are generally similar to those found in the vagina, which suggests that the cervical canal is the most common pathway for bacteria to enter the uterine cavity [128]. As discussed above, the CMP plays an important role in preventing the ascent of infection, and a shorter, more permeable, and less mucoadhesive CMP has been found in women at high risk for preterm birth compared with those at low risk [53].…”

Section: Bacterial Vaginal Infection During Pregnancymentioning

confidence: 76%

“…The mucus of the CMP continues to flow into the vaginal compartment throughout the pregnancy so that the CMP always contains freshly synthesized mucus. Abnormalities of the CMP, such as short length and excessive porosity, are associated with uterine infection and preterm birth [52,53]. Animal and human studies indicate that intra-amniotic infection through the cervical route triggers an inflammatory response leading to preterm labor [54].…”

Section: The Cervical Mucus Plugmentioning

confidence: 99%

“…Gel-forming mucins are mainly responsible for the viscoelastic properties of the CMP and altered permeability properties of the CMP likely result from underproduction or degradation of GFMs and/or the modification of mucin-associated glycans by bacteria usually associated with a dysbiotic vaginal flora, as discussed above. It has also been suggested that a decrease in sialic acid residues in GFM carbohydrates might increase the net charge of mucins, and thereby alter the mucoadhesive properties of the CMP and repulse cationic AMPs [53]. This could explain the insufficient antimicrobial properties of the CMP for killing some pathogenic bacteria such as Group B Streptococcus and Ureaplasma parvum [55,67].…”

Section: Bacterial Vaginal Infection During Pregnancymentioning

confidence: 99%

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The Cervicovaginal Mucus Barrier

Lacroix

Gouyer

Gottrand

et al. 2020

IJMS

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Preterm births are a global health priority that affects 15 million babies every year worldwide. There are no effective prognostic and therapeutic strategies relating to preterm delivery, but uterine infections appear to be a major cause. The vaginal epithelium is covered by the cervicovaginal mucus, which is essential to health because of its direct involvement in reproduction and functions as a selective barrier by sheltering the beneficial lactobacilli while helping to clear pathogens. During pregnancy, the cervical canal is sealed with a cervical mucus plug that prevents the vaginal flora from ascending toward the uterine compartment, which protects the fetus from pathogens. Abnormalities of the cervical mucus plug and bacterial vaginosis are associated with a higher risk of preterm delivery. This review addresses the current understanding of the cervicovaginal mucus and the cervical mucus plug and their interactions with the microbial communities in both the physiological state and bacterial vaginosis, with a focus on gel-forming mucins. We also review the current state of knowledge of gel-forming mucins contained in mouse cervicovaginal mucus and the mouse models used to study bacterial vaginosis.

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“…[7,26]. In this process, it is thought that the host defense system, such as the cervical canal and cervical mucus, plays an important role [85][86][87][88]. A solid body of evidence indicates that a short cervical length is associated with intra-amniotic infection/inflammation [68,71,[89][90][91] and development of spontaneous preterm birth [68,90,.…”

Section: Intra-amniotic Infection By Ureaplasma Sppmentioning

confidence: 99%

The earlier the gestational age, the greater the intensity of the intra-amniotic inflammatory response in women with preterm premature rupture of membranes and amniotic fluid infection byUreaplasmaspecies

Romero

Park

et al. 2019

Journal of Perinatal Medicine

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Objectives To determine the relationship between the intensity of the intra-amniotic inflammatory response and the gestational age at the time of diagnosis in cases with preterm premature rupture of membranes (PROM) and intra-amniotic infection caused by Ureaplasma spp. Methods A retrospective cohort study was conducted which included 71 women with preterm PROM and a positive amniotic fluid culture with Ureaplasma spp. Women with mixed intra-amniotic infections were excluded. The study population was classified into three groups according to gestational age: group 1, <26 weeks (extreme preterm PROM, n = 17); group 2, 26.0–33.9 weeks (moderate preterm PROM, n = 39); group 3, 34.0–36.9 weeks (late preterm PROM, n = 15). The intensity of the intra-amniotic and maternal inflammatory response was compared among the three groups. The intensity of the intra-amniotic inflammatory response was assessed by the concentration of amniotic fluid matrix metalloproteinase-8 (MMP-8) and white blood cell (WBC) count. The maternal inflammatory response was assessed by the concentration of C-reactive protein (CRP) and WBC count in maternal blood at the time of amniocentesis. Results (1) The median values of amniotic fluid MMP-8 concentration and WBC count were the highest in the extreme preterm PROM group and the lowest in the late preterm PROM group (P < 0.001 and P = 0.01, respectively); (2) the intensity of the maternal inflammatory response measured by maternal blood WBC count and CRP concentration was not significantly associated with gestational age at the time of diagnosis. Conclusion The earlier the gestational age at the time of PROM, the higher the intensity of the intra-amniotic inflammatory response in women with preterm PROM and intra-amniotic infection caused by Ureaplasma spp.

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Probing the potential of mucus permeability to signify preterm birth risk

Cited by 29 publications

References 59 publications

The Role of Fatty Acid Metabolites in Vaginal Health and Disease: Application to Candidiasis

The Role of Fatty Acid Metabolites in Vaginal Health and Disease: Application to Candidiasis

The Cervicovaginal Mucus Barrier

The earlier the gestational age, the greater the intensity of the intra-amniotic inflammatory response in women with preterm premature rupture of membranes and amniotic fluid infection byUreaplasmaspecies

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