Probing the molecular determinant of the lipase-specific foldase Lif26 for the interaction with its cognate Lip26

Zheng, Xiaomei; Tian, Jian; Wu, Ningfeng; Fan, Yanting

doi:10.1016/j.ijbiomac.2012.11.007

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…In A. baumannii , major T2SS effectors include the metalloendopeptidase, CpaA, and the lipases, LipA and LipH ( Johnson et al, 2016 ; Weber et al, 2017 ). Secretion of CpaA and LipA requires specific membrane-associated chaperones CpaB and LipB ( Zheng et al, 2013 ; Harding, 2016 ). In particular, LipA contributes to extracellular lipolytic activity by using long-chain fatty acids as carbon sources for growth and may use fatty acids derived through lipid hydrolysis as signaling molecules allowing bacterial escape from innate immunity ( Johnson et al, 2016 ; Lee et al, 2017 ).…”

Section: Virulence and Pathogenicitymentioning

confidence: 99%

Acinetobacter baumannii in the critically ill: complex infections get complicated

et al. 2023

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Acinetobacter baumannii is increasingly associated with various epidemics, representing a serious concern due to the broad level of antimicrobial resistance and clinical manifestations. During the last decades, A. baumannii has emerged as a major pathogen in vulnerable and critically ill patients. Bacteremia, pneumonia, urinary tract, and skin and soft tissue infections are the most common presentations of A. baumannii, with attributable mortality rates approaching 35%. Carbapenems have been considered the first choice to treat A. baumannii infections. However, due to the widespread prevalence of carbapenem-resistant A. baumannii (CRAB), colistin represents the main therapeutic option, while the role of the new siderophore cephalosporin cefiderocol still needs to be ascertained. Furthermore, high clinical failure rates have been reported for colistin monotherapy when used to treat CRAB infections. Thus, the most effective antibiotic combination remains disputed. In addition to its ability to develop antibiotic resistance, A. baumannii is also known to form biofilm on medical devices, including central venous catheters or endotracheal tubes. Thus, the worrisome spread of biofilm-producing strains in multidrug-resistant populations of A. baumannii poses a significant treatment challenge. This review provides an updated account of antimicrobial resistance patterns and biofilm-mediated tolerance in A. baumannii infections with a special focus on fragile and critically ill patients.

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Section: Virulence and Pathogenicitymentioning

confidence: 99%

Acinetobacter baumannii in the critically ill: complex infections get complicated

et al. 2023

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“…Two Acinetobacter T2SS effectors, LipA and CpaA, were found to require membrane bound chaperones, LipB and CpaB respectively, for their secretion [26, 28]. Topological prediction servers and bioinformatic analysis of these membrane bound chaperones suggested that their N-terminal transmembrane domains are imbedded in the inner membrane, with the C-terminal globular portions present in the periplasm.…”

Section: Type II Secretionmentioning

confidence: 99%

The Secrets of Acinetobacter Secretion

Weber

Kinsella

Harding

et al. 2017

Trends in Microbiology

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Infections caused by the bacterial pathogen Acinetobacter baumannii are a mounting concern for healthcare practitioners as widespread antibiotic resistance continues to limit therapeutic treatment options. The biological processes used by A. baumannii to cause disease are not well-defined, but recent research has indicated that secreted proteins may play a major role. A variety of mechanisms have now been shown to contribute to protein secretion by A. baumannii and other pathogenic species of Acinetobacter, including a type II and type VI secretion system, autotransporter, and outer membrane vesicles. In this review, we summarize the current knowledge of secretion systems in Acinetobacter species, and highlight their unique aspects that contribute to the pathogenicity and persistence of these emerging pathogens.

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Predicting recombinant protein expression experiments using molecular dynamics simulation

Schaller

Connors

Oelmeier

et al. 2015

Chemical Engineering Science

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Probing the molecular determinant of the lipase-specific foldase Lif26 for the interaction with its cognate Lip26

Cited by 3 publications

References 26 publications

Acinetobacter baumannii in the critically ill: complex infections get complicated

Acinetobacter baumannii in the critically ill: complex infections get complicated

The Secrets of Acinetobacter Secretion

Predicting recombinant protein expression experiments using molecular dynamics simulation

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