“…Chromatin components, including core histones, are loaded in vast excess of what is required for the first divisions (Horard and Loppin, 2015;Adamson and Woodland, 1974;Woodland and Adamson, 1977;Shindo and Amodeo, 2019). In Drosophila, maternal histone stores are sufficient for progression through the MBT, but zygotic histone production is required for progression past the first post-MBT cell cycle (Günesdogan et al, 2010(Günesdogan et al, , 2014Zhang et al, 2018). It has been suggested that overabundant histones compete with transcription factors for DNA binding to repress transcription in the early cycles (Almouzni et al, 1990(Almouzni et al, , 1991Prioleau et al, 1994;Almouzni and Wolffe, 1995;Amodeo et al, 2015;Joseph et al, 2017).…”