Probing the coverage of nanoparticles by biomimetic membranes through nanoplasmonics

Cardellini, Jacopo; Ridolfi, Andrea; Donati, Melissa; Giampietro, Valentina; Brucale, Marco; Valle, Francesco; Bergese, Paolo; Montis, Costanza; Caselli, Lucrezia; Berti, Debora

doi:10.1016/j.jcis.2023.02.073

Cited by 10 publications

(10 citation statements)

References 100 publications

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“…In the latter case, the average interparticle spacing of the Fe 3 O 4 seeds and Au–Fe 3 O 4 NPs adsorbed on the membranes is higher and the number of adhered particles per vesicle is notably reduced. Interestingly, a similar effect was observed for liposomes interacting with citrate-coated AuNPs, despite the different nature of the NPs in terms of size and core composition. ,,, Reasonably, upon adhesion, Fe 3 O 4 seeds release the exchangeable citrate coating and interact with lipid vesicle phosphocholine polar head groups …”

Section: Resultsmentioning

confidence: 61%

“…Interestingly, a similar effect was observed for liposomes interacting with citrate-coated AuNPs, despite the different nature of the NPs in terms of size and core composition. 30,34,38,41 Reasonably, upon adhesion, Fe 3 O 4 seeds release the exchangeable citrate coating and interact with lipid vesicle phosphocholine polar head groups. 47 The crucial role of membrane rigidity in the interaction with Au−Fe 3 O 4 NPs is also apparent from the color change of the dispersion, more pronounced and detectable, even to the naked eye, in the case of DOPC vesicles (see the inset in Figure 3a,b).…”

Section: Structural Analysis Of Au−fe 3 O 4 -Liposome Hybridsmentioning

confidence: 99%

“…In recent studies, we demonstrated that hydrophilic citrate-capped gold nanoparticles (AuNPs) spontaneously associate with the zwitterionic membrane of liposomes, forming AuNP-decorated liposome hybrids according to a membrane-templated process occurring via simple self-assembly steps. − This peculiar aggregative phenomenon, comporting the spectral variations of the plasmonic properties of AuNPs, ,− has been exploited in various colorimetric assays for the determination of rigidity and concentration of synthetic and natural vesicles as well as for estimating the degree of lipid coverage in membrane-camouflaged inorganic NPs …”

Section: Introductionmentioning

confidence: 99%

“…30−35 This peculiar aggregative phenomenon, comporting the spectral variations of the plasmonic properties of AuNPs, 21,36−38 has been exploited in various colorimetric assays for the determination of rigidity 39 and concentration of synthetic and natural vesicles 40 as well as for estimating the degree of lipid coverage in membrane-camouflaged inorganic NPs. 41 Here, we prepared citrate-capped magnetic−plasmonic NPs (Au−Fe 3 O 4 NPs) and investigated their interaction with synthetic liposomes, aiming at exploring the possibility to exploit a spontaneous self-assembly pathway for the preparation of controlled nanoparticle−liposome adducts with tailored optical and magnetic properties, i.e., magnetic−plasmonic liposomes. To this aim, we first investigated the spontaneous assembly of the Au−Fe 3 O 4 NPs with two prototypical liposomal formulations of DOPC (1,2-dioleoyl-sn-glycero-3phosphocholine) and DPPC (1-dipalmitoyl-sn-glycero-3-phosphocholine), characterized by very different membrane rigidities (see Scheme 1).…”

Section: Introductionmentioning

confidence: 99%

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Magnetic–Plasmonic Nanoscale Liposomes with Tunable Optical and Magnetic Properties for Combined Multimodal Imaging and Drug Delivery

Cardellini,

Surpi,

Muzzi

et al. 2024

ACS Appl. Nano Mater.

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Magnetic−plasmonic nanoparticles (NPs) have shown remarkable potential in hyperthermia, magnetic resonance imaging, and surface-enhanced Raman scattering imaging and diagnostics. However, despite their promise, effective clinical translation remains limited due to a lack of fundamental knowledge about the biological response to these materials, and ongoing efforts seek to bridge the gap between nanomaterial design and effective applicability. To overcome these hurdles, the combination of inorganic NPs with lipid membranes has emerged as an attractive strategy for the biocompatibilization of nanomaterials, preserving the inherent properties of each component and exhibiting synergistic functionalities. This study explores the structural and dynamic aspects of magnetic−plasmonic liposomes produced via spontaneous self-assembly of Au−Fe 3 O 4 NPs and synthetic liposomes, as a function of the lipid vesicles' composition and concentration. By combining cryogenic electron microscopy, ultraviolet-visible spectroscopy, and dynamic light scattering, we demonstrated that the bending rigidity and fluidity of the lipid membrane control the aggregation of the NPs on the membrane and the colloidal stability of the hybrids. The experimental results demonstrate that the coexistence of 10 nm Fe 3 O 4 magnetic seeds and 50 nm Au−Fe 3 O 4 NPs plays a crucial role in the assembly of lipid-NP magnetic−plasmonic hybrids. This thermodynamic control allows for fine adjustment of the hybrids' size and composition, thereby allowing for enhancement and tuning of the magnetic response. Overall, these results pave the way for the development of multifunctional nanomaterials with controlled magnetic−plasmonic properties, obtained via spontaneous self-assembly, as combined nanoprobes and nanovectors for potential applications in multimodal imaging and drug delivery.

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Section: Resultsmentioning

confidence: 61%

Section: Structural Analysis Of Au−fe 3 O 4 -Liposome Hybridsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Magnetic–Plasmonic Nanoscale Liposomes with Tunable Optical and Magnetic Properties for Combined Multimodal Imaging and Drug Delivery

Cardellini,

Surpi,

Muzzi

et al. 2024

ACS Appl. Nano Mater.

Self Cite

View full text Add to dashboard Cite

show abstract

“…[32][33][34][35][36] This peculiar aggregative phenomenon, comporting the spectral variations of the plasmonic properties of AuNPs, 23,[37][38][39] has been exploited in various colorimetric assays for the determination of rigidity 40 and concentration of synthetic and natural vesicles 41 as well as for estimating the degree of lipid coverage in membrane-camouflaged inorganic NPs. 42 Here, we prepare citrate-capped magnetoplasmonic nanoparticles (Au@Fe3O4NPs) and physicochemically investigate their interaction with synthetic liposomes, aiming at exploring the possibility to exploit simple selfassembly steps for the preparation of controlled nanoparticles-liposome adducts with tailored optical and magnetic properties. To this aim, we first investigated the spontaneous assembly of the Au@Fe3O4NPs with two prototypical liposomal formulations of DOPC (1,2-Dioleoyl-sn-glycero-3-phosphocholine) and DPPC (1dipalmitoyl-sn-glycero-3-phosphocholine), characterized by very different membrane rigidities.…”

Section: Introductionmentioning

confidence: 99%

Spontaneous formation of magnetic-plasmonic liposomes with tunable optical and magnetic properties

Cardellini,

Surpi,

Muzzi

et al. 2023

Preprint

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Magnetoplasmonic NPs have shown remarkable potential in hyperthermia, Magnetic Resonance Imaging (MRI), and Surface Enhanced Raman Scattering (SERS) imaging and diagnostics. However, despite their potential, effective clinical translation remains extremely limited due to a lack of fundamental knowledge about the biological response to these materials, and ongoing efforts seek to bridge the gap between nanomaterial production and effective application. To overcome these hurdles, the combination of inorganic NPs with lipid membranes has emerged as a promising strategy for the biocompatibilization of nanomaterials, preserving the inherent properties of each component and exhibiting novel synergistic functionalities. In this study, we synthesize magnetic-plasmonic-liposome adducts via spontaneous self-assembly. The interaction between magnetic-plasmonic NPs and liposomes was addressed from a physicochemical point of view as a function of liposome composition and concentration. By combining Cryogenic Microscopy, UV-visible spectroscopy and Dynamic Light Scattering we demonstrated that the rigidity of the lipid membrane affects the aggregation of the NPs and the colloidal stability of the NPs-vesicle hybrids. The magnetic responsivity of the hybrids is enhanced as a consequence of the colocalization and crowding of NPs on the lipid membranes and can be finely modulated by varying the number of particles per vesicle. Overall, these results pave the way for the development of multifunctional materials with controlled magnetic-plasmonic properties for a variety of technological applications.

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Microstructure and performance modification of PVDF ultrafiltration membrane via adjusting the composition of coagulation Bath

Zhai,

Kang,

Zhao

et al. 2024

J of Applied Polymer Sci

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In this paper, the effect of the composition of a nonsolvent bath on the physicochemical properties of the polyvinylidene fluoride (PVDF) ultrafiltration membranes were comprehensively investigated using the nonsolvent‐induced phase separation method. Three additives (ethanol, glycerol, or NaCl) were added to the water coagulation bath respectively to obtain different membranes. It was found that the microstructure of the membranes changed from finger‐like structure to the sponge‐like structure with the increase of additives concentration, which successfully improved the retention and mechanical properties of the membranes. In addition, the membrane surface became smoother and more hydrophilic. The membrane fabricated in 30 wt% glycerol bath exhibited outstanding comprehensive properties of retention and anti‐fouling, with a water flux of 243.5 L/(m2 h), a bovine serum albumin rejection of more than 90%, and a flux recovery rate of 97%. From mechanism analysis, the addition of ethanol, glycerol, or NaCl to the coagulation bath altered the thermodynamic stability of the polymer system, and slowed down the rate of solvent and nonsolvent diffusion from a kinetic perspective. This research provides important clues for optimizing the membrane properties, such as flux, rejection, and strength.

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Probing the coverage of nanoparticles by biomimetic membranes through nanoplasmonics

Cited by 10 publications

References 100 publications

Magnetic–Plasmonic Nanoscale Liposomes with Tunable Optical and Magnetic Properties for Combined Multimodal Imaging and Drug Delivery

Magnetic–Plasmonic Nanoscale Liposomes with Tunable Optical and Magnetic Properties for Combined Multimodal Imaging and Drug Delivery

Spontaneous formation of magnetic-plasmonic liposomes with tunable optical and magnetic properties

Microstructure and performance modification of PVDF ultrafiltration membrane via adjusting the composition of coagulation Bath

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