Probing structure in submicronic aqueous assemblies of emulsified microemulsions and charged spherical colloids using SANS and cryo-TEM

Muller, François; Degousée, Thibault; Degrouard, Jéril; Brûlet, Annie; Salonen, Anniina

doi:10.1016/j.jcis.2015.01.007

Cited by 8 publications

(7 citation statements)

References 60 publications

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“…The current work was undertaken as a proof of concept about the influence of chirality on the antibacterial activity and its selective toxicity of the nanoparticle. Many research studies indicate that the NP size is a key parameter for its toxicity to bacteria and mammalian . In addition to the size effect, the nonspecific adsorption on the surface of NPs might affect their binding interaction with the targets, and the final toxicity to bacteria and mammalian cells (Figure S15, Supporting Information).…”

mentioning

confidence: 99%

Chiral Nanoparticle as a New Efficient Antimicrobial Nanoagent

Liu

Geng

et al. 2016

Adv Healthcare Materials

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d-type functionalized nanoparticles (NPs) can bind to MurD ligase with high affinity and inhibit its peptidoglycan synthetic enzyme activity, and finally cause bacterial killing. In contrast, its L-type counterpart displays a negligible effect, indicating that the chiral structure of the functionalized NPs plays an essential role in their binding interaction with MurD and therefore the antibacterial activity.

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mentioning

confidence: 99%

Chiral Nanoparticle as a New Efficient Antimicrobial Nanoagent

Liu

Geng

et al. 2016

Adv Healthcare Materials

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“…This technique is useful for investigating ME structure and phase transitions with increasing water content [ 47 , 48 ]. Electron microscopy techniques such as transmission electron microscopy (TEM) and scanning electron microscopy (SEM) are commonly used to assess ME morphology [ 49 , 50 , 51 , 52 ], providing higher resolution than optical microscopes [ 39 , 53 ]. TEM images are two-dimensional, generated by transmitting electrons through the sample.…”

Section: Introductionmentioning

confidence: 99%

“…SEM is employed to directly visualize the surface features of samples by generating three-dimensional images through the detection of backscattered and secondary electrons [ 39 , 53 ]. Cryo- and freeze-fracture techniques have been developed to minimize the drying artifacts when investigating ME structures using these methods [ 52 , 57 , 58 , 59 , 60 , 61 ]. Typically, MEs exhibit low viscosities and exhibit Newtonian flow behaviors [ 56 ].…”

Section: Introductionmentioning

confidence: 99%

Topical Microemulsions: Skin Irritation Potential and Anti-Inflammatory Effects of Herbal Substances

Leanpolchareanchai

Teeranachaideekul

2023

Pharmaceuticals

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Microemulsions (MEs) have gained prominence as effective drug delivery systems owing to their optical transparency, low viscosity, and thermodynamic stability. MEs, when stabilized with surfactants and/or co-surfactants, exhibit enhanced drug solubilization, prolonged shelf life, and simple preparation methods. This review examines the various types of MEs, explores different preparation techniques, and investigates characterization approaches. Plant extracts and bioactive compounds are well established for their utilization as active ingredients in the pharmaceutical and cosmetic industries. Being derived from natural sources, they serve as preferable alternatives to synthetic chemicals. Furthermore, they have demonstrated a wide range of therapeutic effects, including anti-inflammatory, antimicrobial, and antioxidant activities. However, the topical application of plant extracts and bioactive compounds has certain limitations, such as low skin absorption and stability. To overcome these challenges, the utilization of MEs enables enhanced skin absorption, thereby making them a valuable mode of administration. However, considering the significant surfactant content in MEs, this review evaluates the potential skin irritation caused by MEs containing herbal substances. Additionally, the review explores the topical application of MEs specifically for herbal substances, with an emphasis on their anti-inflammatory properties.

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“…In contrast to SAXS, small-angle neutron scattering (SANS) probes the organic stabilizing shell around NP cores owing to the high sensitivity of neutron to hydrogen. Deuterated solvents have been used to reduce the incoherent SANS intensity and enhance the contrast of protonated organic shells. − Only a few studies have been reported on the shell thickness and solvation structure of alkanethiol ligands on Au NPs dispersed in mixtures of organic solvents and antisolvents (e.g., a mixture of n -hexane- d 14 /ethanol- d 6 ) using contrast-variation SANS (CV-SANS) measurements . Smith et al demonstrated the interaction of deuterium-labeled AOT (AOT- d 34 ) with poly(methyl methacrylate) latex particles dispersed in nonpolar solvents ( n -dodecane- d 26 and toluene- d 8 ) through CV-SANS measurements.…”

Section: Introductionmentioning

confidence: 99%

Combined Small-Angle Neutron Scattering/Small-Angle X-ray Scattering Analysis for the Characterization of Silver Nanoparticles Prepared via Photoreduction in Water-in-Oil Microemulsions

2021

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In this study, we used small-angle neutron scattering (SANS) and small-angle X-ray scattering (SAXS) to investigate the formation process of silver (Ag) nanoparticles (NPs) in water-in-oil (w/o) reverse microemulsions comprising sodium bis(2-ethylhexyl) sulfosuccinate (AOT), water, and organic solvents (such as benzene, octane, and decane) by the photoreduction of silver perchlorate (AgClO4). Combining SANS and SAXS, the structural changes in the w/o microemulsions before and after the formation of Ag NPs via photoreduction were quantitatively evaluated. From the SANS experiments performed using the contrast-variation method, the size of water cores containing Ag NPs and the thickness of the AOT shells were calculated using the core–shell hard-sphere model. The size of the Ag NPs and their aggregates was calculated via SAXS analysis based on the polydisperse sphere model with a Schulz–Zimm distribution. We found that aggregates of three or four primary Ag NPs are formed by, first, the aggregation of water droplets through the entanglement of the tails of the AOT shell, followed by the self-assembly of Ag NPs into their aggregates because of particle–particle attractive interactions.

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Probing structure in submicronic aqueous assemblies of emulsified microemulsions and charged spherical colloids using SANS and cryo-TEM

Cited by 8 publications

References 60 publications

Chiral Nanoparticle as a New Efficient Antimicrobial Nanoagent

Chiral Nanoparticle as a New Efficient Antimicrobial Nanoagent

Topical Microemulsions: Skin Irritation Potential and Anti-Inflammatory Effects of Herbal Substances

Combined Small-Angle Neutron Scattering/Small-Angle X-ray Scattering Analysis for the Characterization of Silver Nanoparticles Prepared via Photoreduction in Water-in-Oil Microemulsions

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