“…Biomacromolecules like DNA, actin, collagen, and polysaccharides, as well as synthetic polymers like poly(benzyl glutamate) and Kevlar, are often considered semiflexible ,,,− due to the relatively large values of l p . Semiflexibility influences both thermodynamic and hydrodynamic properties. − ,,− Here, we consider polysaccharides to be semiflexible chains, recognizing the fact that their static and dynamic behavior is distinct from the behavior exhibited by semiflexible filaments like actin, collagen, carbon nanotubes, and fd-virus; for the latter, the contour length is comparable to the persistence length or N K ≈ O(10) (or lower). ,, In this contribution, we specifically chose HEC and PEO with comparable molecular weight and matched overlap concentration c* . Nevertheless, the computed N K = 70 for HEC ( M w = 7.2 × 10 5 g/mol) is nearly two orders of magnitude lower than N K = 9280 for PEO ( M w = 1 × 10 6 g/mol), whereas b K HEC = 20 nm is relatively large in comparison to b K PEO = 1.1 nm.…”