Probing Skin for Metabolites and Topical Drugs with Hydrogel Micropatches

Dutkiewicz, Ewelina P.; Chiu, Hsien-Yi; Urban, Pawel L.

doi:10.1021/acs.analchem.6b04276

Cited by 29 publications

(31 citation statements)

References 48 publications

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“…They emphasized that the addition of ethanol into water induces a smaller surface tension of the solution to the skin allowing the solution to penetrate the sweat gland effectively. This sweat collection method has also been used for recent proteomic and metabolomic analyses 21–24 . K. Hooton and L. Li suggested clear correlation between real and extracted sweat 23 , and M. Tsunoda et al .…”

Section: Introductionmentioning

confidence: 99%

Noninvasive Sweat-Lactate Biosensor Emplsoying a Hydrogel-Based Touch Pad

Nagamine

Mano

Nomura

et al. 2019

Sci Rep

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This study is the first report demonstrating proof-of-concept for a hydrogel-based touch sensor pad used for the non-invasive extraction and detection of sweat components. The sensor device was composed of an electrochemical L-lactate biosensor covered with an agarose gel in a phosphate buffer saline. When human skin contacts the agarose gel, L-lactate in sweat was continuously extracted into the gel, followed by in-situ potentiometric detection without controlled conditions. This novel type of sweat sensor is expected to enable the simple, non-invasive daily periodic monitoring of sweat biomarkers for advanced personal healthcare methods in the future.

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Section: Introductionmentioning

confidence: 99%

Noninvasive Sweat-Lactate Biosensor Emplsoying a Hydrogel-Based Touch Pad

Nagamine

Mano

Nomura

et al. 2019

Sci Rep

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“…This sweat component sampling method has also been used for recent proteomic and metabolomic analyses. [110][111][112] Tsunoda et al 113 suggested a clear correlation between extracted sweat and plasma component levels.…”

Section: Sweat Biomarkers and Their Collection/ Detection Techniquesmentioning

confidence: 99%

“…Therefore, the extracted sweat components were quantified using a separately prepared highly sensitive analytical system, such as liquid chromatography and mass spectrometry. [108][109][110][111][112][113] These analytical systems are not compatible with daily healthcare applications due to its size, cost, and requirement of high technical skill. For daily healthcare, this sweat extraction technique should be combined with portable and highly sensitive biosensors for on-site detection of the extracted low level of sweat components.…”

Section: Sweat Biomarkers and Their Collection/ Detection Techniquesmentioning

confidence: 99%

Printed Organic Transistor-based Biosensors for Non-invasive Sweat Analysis

et al. 2020

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The concept of the Internet of Things (IoT), which connects objects to a network via various types of sensors to solve global societal needs, is now spreading to various application fields to achieve an emerging "smart lifestyle". Healthcare is one of the most attractive applications of IoT, because it provides various healthcare services for individuals, including daily health monitoring, fitness support, and elderly care. To realize these applications, there is a need to develop simple portable sensor devices that can be used anywhere, including non-medical

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“…However, several studies have characterized the skin metabolome in a wider context. These have used a variety of sample types, including skin swabs, hydrogel micropatches (127), punch biopsy specimens, and sweat. In one study analyzing epidermal skin tissue, several bacterium-derived metabolites (128) and bacterial substrates were observed, including p-cresol, a product of bacterial tyrosine metabolism.…”

Section: Metabolomic Analysesmentioning

confidence: 99%

Consumer Safety Considerations of Skin and Oral Microbiome Perturbation

et al. 2019

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SUMMARY Microbiomes associated with human skin and the oral cavity are uniquely exposed to personal care regimes. Changes in the composition and activities of the microbial communities in these environments can be utilized to promote consumer health benefits, for example, by reducing the numbers, composition, or activities of microbes implicated in conditions such as acne, axillary odor, dandruff, and oral diseases. It is, however, important to ensure that innovative approaches for microbiome manipulation do not unsafely disrupt the microbiome or compromise health, and where major changes in the composition or activities of the microbiome may occur, these require evaluation to ensure that critical biological functions are unaffected. This article is based on a 2-day workshop held at SEAC Unilever, Sharnbrook, United Kingdom, involving 31 specialists in microbial risk assessment, skin and oral microbiome research, microbial ecology, bioinformatics, mathematical modeling, and immunology. The first day focused on understanding the potential implications of skin and oral microbiome perturbation, while approaches to characterize those perturbations were discussed during the second day. This article discusses the factors that the panel recommends be considered for personal care products that target the microbiomes of the skin and the oral cavity.

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Probing Skin for Metabolites and Topical Drugs with Hydrogel Micropatches

Cited by 29 publications

References 48 publications

Noninvasive Sweat-Lactate Biosensor Emplsoying a Hydrogel-Based Touch Pad

Noninvasive Sweat-Lactate Biosensor Emplsoying a Hydrogel-Based Touch Pad

Printed Organic Transistor-based Biosensors for Non-invasive Sweat Analysis

Consumer Safety Considerations of Skin and Oral Microbiome Perturbation

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