2017
DOI: 10.1021/acs.analchem.6b04276
|View full text |Cite
|
Sign up to set email alerts
|

Probing Skin for Metabolites and Topical Drugs with Hydrogel Micropatches

Abstract: Sampling the skin surface is a convenient way to obtain biological specimens bearing clinically relevant information. Hydrogel micropatches enable noninvasive collection of skin excretion specimens, which can subsequently be subjected to rapid mass spectrometric analysis providing insights into the skin metabolome.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

0
33
0

Year Published

2017
2017
2024
2024

Publication Types

Select...
5
4

Relationship

1
8

Authors

Journals

citations
Cited by 30 publications
(33 citation statements)
references
References 48 publications
0
33
0
Order By: Relevance
“…They emphasized that the addition of ethanol into water induces a smaller surface tension of the solution to the skin allowing the solution to penetrate the sweat gland effectively. This sweat collection method has also been used for recent proteomic and metabolomic analyses 2124 . K. Hooton and L. Li suggested clear correlation between real and extracted sweat 23 , and M. Tsunoda et al .…”
Section: Introductionmentioning
confidence: 99%
“…They emphasized that the addition of ethanol into water induces a smaller surface tension of the solution to the skin allowing the solution to penetrate the sweat gland effectively. This sweat collection method has also been used for recent proteomic and metabolomic analyses 2124 . K. Hooton and L. Li suggested clear correlation between real and extracted sweat 23 , and M. Tsunoda et al .…”
Section: Introductionmentioning
confidence: 99%
“…This sweat component sampling method has also been used for recent proteomic and metabolomic analyses. [110][111][112] Tsunoda et al 113 suggested a clear correlation between extracted sweat and plasma component levels.…”
Section: Sweat Biomarkers and Their Collection/ Detection Techniquesmentioning
confidence: 99%
“…Therefore, the extracted sweat components were quantified using a separately prepared highly sensitive analytical system, such as liquid chromatography and mass spectrometry. [108][109][110][111][112][113] These analytical systems are not compatible with daily healthcare applications due to its size, cost, and requirement of high technical skill. For daily healthcare, this sweat extraction technique should be combined with portable and highly sensitive biosensors for on-site detection of the extracted low level of sweat components.…”
Section: Sweat Biomarkers and Their Collection/ Detection Techniquesmentioning
confidence: 99%
“…However, several studies have characterized the skin metabolome in a wider context. These have used a variety of sample types, including skin swabs, hydrogel micropatches (127), punch biopsy specimens, and sweat. In one study analyzing epidermal skin tissue, several bacterium-derived metabolites (128) and bacterial substrates were observed, including p-cresol, a product of bacterial tyrosine metabolism.…”
Section: Metabolomic Analysesmentioning
confidence: 99%