Probing predatory bacteria as an antibacterial remedy

Madhusoodanan, Jyoti

doi:10.1073/pnas.1917513116

Cited by 14 publications

(15 citation statements)

References 7 publications

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“…ASV’s analysis of the three sponges, M. ( Oxymycale ) acerata , H. pilosus and H. ( Rhizoniera ) dancoi , displayed Deltaproteobacteria ( Figure 2 ; Tables S5–S7 ) belonging to the phylum Proteobacteria, that, as mentioned above, produce interesting bioactive metabolites [ 57 ]. For instance, H. pilosus exhibited some strains included into the genus Bdellovibrio ( Figure 3 ; Table S7 ), which is an obligate predator of other Gram-negative bacteria that was proposed for possible biotechnological applications toward medicinal, agricultural and industrial fields [ 113 , 114 , 115 ].…”

Section: Discussionmentioning

confidence: 99%

A Metataxonomic Approach Reveals Diversified Bacterial Communities in Antarctic Sponges

et al. 2021

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Marine sponges commonly host a repertoire of bacterial-associated organisms, which significantly contribute to their health and survival by producing several anti-predatory molecules. Many of these compounds are produced by sponge-associated bacteria and represent an incredible source of novel bioactive metabolites with biotechnological relevance. Although most investigations are focused on tropical and temperate species, to date, few studies have described the composition of microbiota hosted by Antarctic sponges and the secondary metabolites that they produce. The investigation was conducted on four sponges collected from two different sites in the framework of the XXXIV Italian National Antarctic Research Program (PNRA) in November–December 2018. Collected species were characterized as Mycale (Oxymycale) acerata, Haliclona (Rhizoniera) dancoi, Hemigellius pilosus and Microxina sarai by morphological analysis of spicules and amplification of four molecular markers. Metataxonomic analysis of these four Antarctic sponges revealed a considerable abundance of Amplicon Sequence Variants (ASVs) belonging to the phyla Proteobacteria, Bacteroidetes, Actinobacteria and Verrucomicrobia. In particular, M. (Oxymycale) acerata, displayed several genera of great interest, such as Endozoicomonas, Rubritalea, Ulvibacter, Fulvivirga and Colwellia. On the other hand, the sponges H. pilosus and H. (Rhizoniera) dancoi hosted bacteria belonging to the genera Pseudhongella, Roseobacter and Bdellovibrio, whereas M. sarai was the sole species showing some strains affiliated to the genus Polaribacter. Considering that most of the bacteria identified in the present study are known to produce valuable secondary metabolites, the four Antarctic sponges could be proposed as potential tools for the discovery of novel pharmacologically active compounds.

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Section: Discussionmentioning

confidence: 99%

A Metataxonomic Approach Reveals Diversified Bacterial Communities in Antarctic Sponges

et al. 2021

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“…Obligate predatory bacteria, including Bdellovibrio bacteriovorus and Micavibrio aeruginosavorus , populate soils and water globally [ 87 ]. Epibiotic or endobiotic predatory bacteria are attached to the membrane of the Gram-negative bacteria to consume prey contents and divide outside or inside their prey [ 88 , 89 , 90 ]. Several studies have demonstrated that B. bacteriovorus can kill more than 100 human bacterial pathogens acting as “living antibiotic” [ 91 ].…”

Section: Alternative Strategies To Combat Antibiotic Resistancementioning

confidence: 99%

Antibiotics in Food Chain: The Consequences for Antibiotic Resistance

2020

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Antibiotics have been used as essential therapeutics for nearly 100 years and, increasingly, as a preventive agent in the agricultural and animal industry. Continuous use and misuse of antibiotics have provoked the development of antibiotic resistant bacteria that progressively increased mortality from multidrug-resistant bacterial infections, thereby posing a tremendous threat to public health. The goal of our review is to advance the understanding of mechanisms of dissemination and the development of antibiotic resistance genes in the context of nutrition and related clinical, agricultural, veterinary, and environmental settings. We conclude with an overview of alternative strategies, including probiotics, essential oils, vaccines, and antibodies, as primary or adjunct preventive antimicrobial measures or therapies against multidrug-resistant bacterial infections. The solution for antibiotic resistance will require comprehensive and incessant efforts of policymakers in agriculture along with the development of alternative therapeutics by experts in diverse fields of microbiology, biochemistry, clinical research, genetic, and computational engineering.

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“…Moreover, the relatively benign occupancy of macrophages by Bdellovibrio could prevent other intracellular pathogens from entering. However, this passive uptake suggests that macrophages might present predatory bacteria to antibody-forming cells and, consequently, humans could develop immune reactions against them after repeated exposures [30] . In fact, Raghunathan et al .…”

Section: Balos As Biocontrol Agentsmentioning

confidence: 99%

“…Predatory bacteria play an essential role in these new lines of research [16] , [28] , [29] , [30] , [31] . The fact that these micropredators are designed to lyse and kill other bacteria, including MDRB and those pathogens that form biofilms, has led to them being proposed as a reasonable antibiotic alternative to be explored.…”

Section: Introductionmentioning

confidence: 99%