Probing membrane deformation energy by KcsA potassium channel gating under varied membrane thickness and tension
Yuka Matsuki,
Masako Takashima,
Misuzu Ueki
et al.
Abstract:This study investigated how membrane thickness and tension modify the gating of KcsA potassium channels when simultaneously varied. The KcsA channel undergoes global conformational changes upon gating: expansion of the cross‐sectional area and longitudinal shortening upon opening. Thus, membranes impose differential effects on the open and closed conformations, such as hydrophobic mismatches. Here, the single‐channel open probability was recorded in the contact bubble bilayer, by which variable thickness membr… Show more
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