Probing lipids relaxation times in breast cancer using magnetic resonance spectroscopic fingerprinting

Nissan, Noam; Kulpanovich, Alexey; Agassi, Ravit; Allweis, Tanir; Haas, Ilana; Carmon, Einat; Furman‐Haran, Edna; Anaby, Debbie; Sklair‐Levy, Miri; Tal, Assaf

doi:10.1007/s00330-023-09560-w

Cited by 2 publications

(2 citation statements)

References 59 publications

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“…The analysis revealed seven lipid metabolite peaks with significant differences in relaxation times between cancer and normal tissue at specific resonances (1.3 ppm, 4.1 ppm, and 5.22 ppm for T1, and 5.31 ppm for T2). The results suggest that MRSF is a feasible and time-efficient technique for assessing lipid relaxation times in breast cancer, potentially serving as quantitative markers for distinguishing normal and cancerous tissues [ 126 ]. Further research is needed to understand the biological mechanisms behind these differences.…”

Section: Discussionmentioning

confidence: 99%

Magnetic Resonance Imaging in Breast Cancer Tissue In Vitro after PDT Therapy

Bartusik-Aebisher,

Mytych,

Dynarowicz

et al. 2024

Diagnostics

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Photodynamic therapy (PDT) is increasingly used in modern medicine. It has found application in the treatment of breast cancer. The most common cancer among women is breast cancer. We collected cancer cells from the breast from the material received after surgery. We focused on tumors that were larger than 10 mm in size. Breast cancer tissues for this quantitative non-contrast magnetic resonance imaging (MRI) study could be seen macroscopically. The current study aimed to present findings on quantitative non-contrast MRI of breast cancer cells post-PDT through the evaluation of relaxation times. The aim of this work was to use and optimize a 1.5 T MRI system. MRI tests were performed using a clinical scanner, namely the OPTIMA MR360 manufactured by General Electric HealthCare. The work included analysis of T1 and T2 relaxation times. This analysis was performed using the MATLAB package (produced by MathWorks). The created application is based on medical MRI images saved in the DICOM3.0 standard. T1 and T2 measurements were subjected to the Shapiro–Wilk test, which showed that both samples belonged to a normal distribution, so a parametric t-test for dependent samples was used to test for between-sample variability. The study included 30 sections tested in 2 stages, with consistent technical parameters. For T1 measurements, 12 scans were performed with varying repetition times (TR) and a constant echo time (TE) of 3 ms. For T2 measurements, 12 scans were performed with a fixed repetition time of 10,000 ms and varying echo times. After treating samples with PpIX disodium salt and bubbling with pure oxygen, PDT irradiation was applied. The cell relaxation time after therapy was significantly shorter than the cell relaxation time before PDT. The cells were exposed to PpIX disodium salt as the administered pharmacological substance. The study showed that the therapy significantly affected tumor cells, which was confirmed by a significant reduction in tumor cell relaxation time on the MRI results.

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Section: Discussionmentioning

confidence: 99%

Magnetic Resonance Imaging in Breast Cancer Tissue In Vitro after PDT Therapy

Bartusik-Aebisher,

Mytych,

Dynarowicz

et al. 2024

Diagnostics

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“…Diffusion tensor imaging (DTI) is a functional MRI technique that demonstrates the direction and speed of water molecule diffusion in biological tissues [ 20 ]. DTI can provide both mean diffusivity (MD) and fractional anisotropy (FA) values, which might reflect the structure and organization of complex tissues such as the brain, heart, prostate, kidney, liver, and breast [ 21 , 22 , 23 , 24 ]. Recent studies have reported that the quantitative parameter values of DTI are useful to differentiate the testes of NOA patients from controls and the testes of infertile men with varicocele from controls [ 18 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Noninvasive Prediction of Sperm Retrieval Using Diffusion Tensor Imaging in Patients with Nonobstructive Azoospermia

Gao,

Yang,

Chen

et al. 2023

J. Imaging

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Microdissection testicular sperm extraction (mTESE) is the first-line treatment plan for nonobstructive azoospermia (NOA). However, studies reported that the overall sperm retrieval rate (SRR) was 43% to 63% among men with NOA, implying that nearly half of the patients fail sperm retrieval. This study aimed to evaluate the diagnostic performance of parameters derived from diffusion tensor imaging (DTI) in predicting SRR in patients with NOA. Seventy patients diagnosed with NOA were enrolled and classified into two groups based on the outcome of sperm retrieval during mTESE: success (29 patients) and failure (41 patients). Scrotal magnetic resonance imaging was performed, and the DTI parameters, including mean diffusivity and fractional anisotropy, were analyzed between groups. The results showed that there was a significant difference in mean diffusivity values between the two groups, and the area under the curve for mean diffusivity was calculated as 0.865, with a sensitivity of 72.2% and a specificity of 97.5%. No statistically significant difference was observed in fractional anisotropy values and sex hormone levels between the two groups. This study demonstrated that the mean diffusivity value might serve as a useful noninvasive imaging marker for predicting the SRR of NOA patients undergoing mTESE.

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Probing lipids relaxation times in breast cancer using magnetic resonance spectroscopic fingerprinting

Cited by 2 publications

References 59 publications

Magnetic Resonance Imaging in Breast Cancer Tissue In Vitro after PDT Therapy

Magnetic Resonance Imaging in Breast Cancer Tissue In Vitro after PDT Therapy

Noninvasive Prediction of Sperm Retrieval Using Diffusion Tensor Imaging in Patients with Nonobstructive Azoospermia

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