Probing lipid membrane bending mechanics using gold nanorod tracking

Molaei, Mehdi; Kandy, Sreeja Kutti; Graber, Zachary T.; Baumgart, Tobias; Radhakrishnan, Ravi; Crocker, John C.

doi:10.1103/physrevresearch.4.l012027

Cited by 5 publications

(6 citation statements)

References 59 publications

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“…Gold nanorods have risen as a promising candidate in probing the rapid bending undulations of lipid membrane. In a study by Molaei et al, angular motion of singular gold nanorods adhered to the plasma membrane reveals the complex physics and dynamic of a plasma membrane (Molaei et al, 2022).…”

Section: Other Theranostic Applications For Complex Metal Nanoparticlesmentioning

confidence: 99%

A review of recent advances in the use of complex metal nanostructures for biomedical applications from diagnosis to treatment

Hajfathalian,

Mossburg,

Radaic

et al. 2024

WIREs Nanomed Nanobiotechnol

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Complex metal nanostructures represent an exceptional category of materials characterized by distinct morphologies and physicochemical properties. Nanostructures with shape anisotropies, such as nanorods, nanostars, nanocages, and nanoprisms, are particularly appealing due to their tunable surface plasmon resonances, controllable surface chemistries, and effective targeting capabilities. These complex nanostructures can absorb light in the near‐infrared, enabling noteworthy applications in nanomedicine, molecular imaging, and biology. The engineering of targeting abilities through surface modifications involving ligands, antibodies, peptides, and other agents potentiates their effects. Recent years have witnessed the development of innovative structures with diverse compositions, expanding their applications in biomedicine. These applications encompass targeted imaging, surface‐enhanced Raman spectroscopy, near‐infrared II imaging, catalytic therapy, photothermal therapy, and cancer treatment. This review seeks to provide the nanomedicine community with a thorough and informative overview of the evolving landscape of complex metal nanoparticle research, with a specific emphasis on their roles in imaging, cancer therapy, infectious diseases, and biofilm treatment.This article is categorized under: Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease Diagnostic Tools > Diagnostic Nanodevices

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Section: Other Theranostic Applications For Complex Metal Nanoparticlesmentioning

confidence: 99%

A review of recent advances in the use of complex metal nanostructures for biomedical applications from diagnosis to treatment

Hajfathalian,

Mossburg,

Radaic

et al. 2024

WIREs Nanomed Nanobiotechnol

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“…24 A recent study showed that tracking of nanorods, with sidewise adhesion to lipid membranes, can be used to probe the mechanical properties of membranes, including their bending modulus and surface tension. 25 In another study, it was shown that magnetic nanorods adhering to a lipid membrane and in an oscillating magnetic field can lead to an increased local fluidization of the membrane and to its lysis. 26 Conflicting experimental results have been reported on the effect of nanorods aspect ratio r = l/D, where l and D are the length and diameter of the nanorod, respectively, on their cellular uptake.…”

Section: Introductionmentioning

confidence: 99%

Membrane-mediated dimerization of spherocylindrical nanoparticles

et al. 2023

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“…It has been applied to the study of complex fluids including biological polymers, live cells and media with inhomogeneous mechanical properties. 22,23 Single-particle microrheology is most often based on tracking translational diffusion of a spherical diffuser. 24 In a similar way, rotational diffusion can reveal changes of the local conditions, either those due to local heterogeneities, or due to temperature changes in the vicinity of a heat source, 25 for example.…”

Section: Introductionmentioning

confidence: 99%

“…As an interesting application, rotational diffusion can be used to explore the effective viscosity of the environment, a method known as nanorheology. − Micro- or nanorheology measures the viscoelastic properties of a medium in small volumes from picoliters with microparticles to attoliters with nanoparticles. It has been applied to the study of complex fluids including biological polymers, live cells and media with inhomogeneous mechanical properties. , …”

Section: Introductionmentioning

confidence: 99%

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Burst-by-Burst Measurement of Rotational Diffusion at Nanosecond Resolution Reveals Hot-Brownian Motion and Single-Chain Binding

2023

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We record dark-field scattering bursts of individual gold nanorods, 52 × 15 nm 2 in average size, freely diffusing in water suspension. We deduce their Brownian rotational diffusion constant from autocorrelation functions on a single-event basis. Due to spectral selection by the plasmonic resonance with the excitation laser, the distribution of rotational diffusion constants is much narrower than expected from the size distribution measured by TEM. As rotational diffusion depends on particle hydrodynamic volume, viscosity, and temperature, it can sense those parameters at the singleparticle level. We demonstrate measurements of hot Brownian rotational diffusion of nanorods in temperature and viscosity gradients caused by plasmonic heating. Further, we monitor hydrodynamic volumes of gold nanorods upon addition of very low concentrations of the water-soluble polymer PVA, which binds to the particles, leading to measurable changes in their diffusion constant corresponding to binding of one to a few polymer coils. We propose this analysis technique for very low concentrations of biomolecules in solution.

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Probing lipid membrane bending mechanics using gold nanorod tracking

Cited by 5 publications

References 59 publications

A review of recent advances in the use of complex metal nanostructures for biomedical applications from diagnosis to treatment

A review of recent advances in the use of complex metal nanostructures for biomedical applications from diagnosis to treatment

Membrane-mediated dimerization of spherocylindrical nanoparticles

Burst-by-Burst Measurement of Rotational Diffusion at Nanosecond Resolution Reveals Hot-Brownian Motion and Single-Chain Binding

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