Probing Early Motion Processing With Eye Movements: Differences of Vestibular Migraine, Migraine With and Without Aura in the Attack Free Interval

Abstract

From the findings, we hypothesize that in the migraine subtypes, MwA and VM, there is different sensory motion information processing for OFR compared to MwoA and control, not explained by a neuronal hyperexcitability in V5. OFR might be a possible subclinical marker in the future to diagnose MwA and VM.

Temporal Integration of Motion Streaks in Migraine

“…The motion streak effect (difference in threshold elevation for motion against orthogonal backgrounds compared to motion against parallel backgrounds) was estimated in both vertical and horizontal motion direction. Both motion orientations were used to control for the possibility of anisotropy in performance, as there is evidence that the optokinetic effect is different in migraine compared to control groupss [24,25]. The motion streak effect was found in both horizontal and vertical motion directions (see Appendix B), and so both directions of motion (set against orthogonal and parallel backgrounds) were used in the main study.…”

“…Vertical and horizontal motion were estimated in the current study, as there are differences in optokinetic reflex eye movements in those with MA as well as those with migraineous vertigo, compared to control groups—those with MA show increased velocity for ocular following movements (the eyes move faster) compared to control participants [24]. Additionally, optokinetic stimulation has been demonstrated to increase motion sickness in those with migraine more than control participants [25].…”

Testsequenzen für den Praktiker

“…Verschiedene Studien weisen darauf hin, dass z. B. Migräniker atypisch auf visuelle Informationen reagieren [12] [13] [14]. Die vom N. opticus ausgelösten Signale aktivieren in der Folge Neuronen im Thalamus, die mit Rezeptorenfeldern der Hirnhaut in Verbindung stehen.…”

“…Die vom N. opticus ausgelösten Signale aktivieren in der Folge Neuronen im Thalamus, die mit Rezeptorenfeldern der Hirnhaut in Verbindung stehen. Daraus wiederum kann eine Sensitivierung der trigeminovaskulären Neurone entstehen [12][13] [14]. Der trigeminovaskuläre Nucleus wiederum ist maßgeblich an der Auslösung einer Migräneattacke beteiligt [15] [16].…”

Investigating Head Movements Induced by ‘Riloid’ Patterns in Migraine and Control Groups Using a Virtual Reality Display

“…Nystagmus eye movements are characteristic of migrainous vertigo (Phillips et al, 2010). Differences in eye-movements related to motion processing has been shown in those with migrainous vertigo, as well as MA, compared to control groups (Rogalinski and Rambold, 2017). In addition, the optokinetic effect is related to postural sway (Blanks et al, 1996), therefore this could be a potential difference for the mechanism in migraine.…”