Probe diffusion in solutions of low-molecular-weight polyelectrolytes

Phillies, George D. J.; Pirnat, Thomas; Kiss, M.; Teasdale, Nancy; Maclung, David; Inglefield, Heather; Malone, C. P.; Rau, Anand; Yu, Li Ping; Rollings, J. E.

doi:10.1021/ma00200a044

Cited by 20 publications

(14 citation statements)

References 17 publications

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“…The coefficients range from 0.5-1 for ν , ∼0.8 for β for polyelectrolytes and 0 for non-electrolytes, and δ is ∼0.3-0.5 for polyelectrolytes and 0 for non-electrolytes; γ is ∼0.8[59]. …”

Section: Mathematical Interpretations Of Solute Diffusion In Mucusmentioning

confidence: 99%

Mathematical modeling of molecular diffusion through mucus

Saltzman

2009

Advanced Drug Delivery Reviews

108

114

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The rate of molecular transport through the mucus gel can be an important determinant of efficacy for therapeutic agents delivered by oral, intranasal, intravaginal/rectal, and intraocular routes. Transport through mucus can be described by mathematical models based on principles of physical chemistry and known characteristics of the mucus gel, its constituents, and of the drug itself. In this paper, we review mathematical models of molecular diffusion in mucus, as well as the techniques commonly used to measure diffusion of solutes in the mucus gel, mucus gel mimics, and mucosal epithelia.

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Section: Mathematical Interpretations Of Solute Diffusion In Mucusmentioning

confidence: 99%

Mathematical modeling of molecular diffusion through mucus

Saltzman

2009

Advanced Drug Delivery Reviews

108

114

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“…on ionic strength Phillies, et al, 1987Phillies, et al, , 1989 . It has been reported that the diffusion coefficient always increases with increasing ionic strength until reaching a plateau at a high ionic strength.…”

Section: Bsa Uptake By Cb-6as and Cb-sepharosementioning

confidence: 99%

Ionic strength dependence of protein adsorption to dye‐ligand adsorbents

Zhang

Sun

2002

AIChE Journal

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“…If we assume crudely that the friction coefficient is the same for each component, then which leads to a cubic equation 3 3 3…”

Section: Cooperatiue Diffusion Coe+cient Dmentioning

confidence: 99%

Mean-field theory of concentrated polyelectrolyte solutions: Statics and dynamics

Vilgis

Borsali

1991

Phys. Rev. A

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This paper discusses the static and dynamic properties for "reasonable" charged polyelectrolyte chains (f & I, where f is the degree of ionization) in semidilute solution (P) P*, where P* is the "overlap" concentration) with and without added salt on the basis of the Edwards-Hamiltonian formalism. In this formalism the hydrodynamical effects are neglected. Expressions for the free energy F, the osmotic pressure ll, the structure factors S;,(q), the charge fluctuations SCF(q), the screened potentials U",(q) for polyions and counterions, and the radius of gyration Ag are derived.As for the dynamics of such systems, two relaxation modes characterize the intermediate scattering function S{q,t). The first mode represents the standard diffusion and is identified as being the cooperative difFusion frequency. It increases with the polyelectrolyte concentration P and with the degree of ionization f [D, (f) )D, (f =0)] and is independent of the Debye screening parameter tc .The second process presents a nonzero frequency at~q~= 0 and is called the "plasmon" mode. The variation with polyelectrolyte concentration P, degree of ionization f, counterion concentration P;, and wave vector q is presented in a systematic way for all measurable quantities. We also present some remarks regarding the statics and dynamics of neutral and polyelectrolyte mixtures in solution.

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Probe diffusion in solutions of low-molecular-weight polyelectrolytes

Cited by 20 publications

References 17 publications

Mathematical modeling of molecular diffusion through mucus

Mathematical modeling of molecular diffusion through mucus

Ionic strength dependence of protein adsorption to dye‐ligand adsorbents

Mean-field theory of concentrated polyelectrolyte solutions: Statics and dynamics

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