Probe beam deflection technique as acoustic emission directionality sensor with photoacoustic emission source

Barnes, Ronald A.; Maswadi, Saher; Glickman, Randolph D.; Shadaram, Mehdi

doi:10.1364/ao.53.000511

Cited by 44 publications

(34 citation statements)

References 26 publications

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“…Using an all optical opto-acoustic approach as described in earlier reports343536. Pure cobalt ferrite nanoparticles were placed in a glass cuvette that was then filled with liquid (de-ionized water) until reaching the top of the cuvette (~4 ml).…”

Section: Resultsmentioning

confidence: 99%

Magneto-elasto-electroporation (MEEP): In-vitro visualization and numerical characteristics

Betal

Shrestha

Dutta

et al. 2016

Sci Rep

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A magnetically controlled elastically driven electroporation phenomenon, or magneto-elasto-electroporation (MEEP), is discovered while studying the interactions between core-shell magnetoelectric nanoparticles (CSMEN) and biological cells in the presence of an a.c. magnetic field. In this paper we report the effect of MEEP observed via a series of in-vitro experiments using core (CoFe2O4)-shell (BaTiO3) structured magnetoelectric nanoparticles and human epithelial cells (HEP2). The cell electroporation phenomenon and its correlation with the magnetic field modulated CSMEN are described in detail. The potential application of CSMEN in electroporation is confirmed by analyzing crystallographic phases, multiferroic properties of the fabricated CSMEN, influences of d.c. and a.c. magnetic fields on the CSMEN and cytotoxicity tests. The mathematical formalism to quantitatively describe the phenomena is also reported. The reported findings provide insights into the underlying MEEP mechanism and demonstrate the utility of CSMEN as an electric pulse-generating nano-probe in electroporation experiments with a potential application toward accurate and efficient targeted cell permeation.

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Section: Resultsmentioning

confidence: 99%

Magneto-elasto-electroporation (MEEP): In-vitro visualization and numerical characteristics

Betal

Shrestha

Dutta

et al. 2016

Sci Rep

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“…The PBDT correlates the deflection of a laser beam propagating through a media of interest with any detectable thermal or acoustic disturbance in the media. This technique has been utilized extensively in the past, for ultrasound and photoacoustic measurement, as well as imaging [17][18][19][20][21]. The technique has been applied to the measurement of acoustic waves in gas phase, namely the gas coupled laser acoustic detector (GCLAD), where detection bandwidth is limited by the speed of sound in air [20,21].…”

Section: Probe Beam Deflection Technique (Pbdt)mentioning

confidence: 99%

Probe beam deflection optical imaging of thermal and mechanical phenomena resulting from nanosecond electric pulse (nsEP) exposure in-vitro

et al. 2017

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Electric-field induced physical phenomena, such as thermal, mechanical and electrochemical dynamics, may be the driving mechanism behind bioeffects observed in mammalian cells during exposure to nanosecond-duration electric pulses (nsEP) in-vitro. Correlating a driving mechanism to a biological response requires the experimental measurement and quantification of all physical dynamics resulting from the nsEP stimulus. A passive and electromagnetic interference (EMI) immune sensor is required to resolve these dynamics in high strength electric fields. The probe beam deflection technique (PBDT) is a passive and EMI immune optical method for quantifying and imaging refractive index gradients in liquids and gases, both dynamic and static, with nanosecond temporal resolution. In this work, a probe beam deflection imaging system was designed to acquire 2-D time-lapse images of thermal/mechanical dynamics resulting from monopolar and bipolar nsEP stimulus.

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“…However, this approach requires two lasers for pumping and probing and a large footprint area for the set up because the probe beam needs to travel a relatively long distance (for increasing deflection angle) before detection to improve sensitivity. 31,32 There are also other air-coupled transducers available, but air-coupled transducers are unfocused, bulky, and exhibit poor SNR, which makes imaging more complicated. 33 Conventional PA imaging systems require expensive ultrafast lasers with nanosecond pulse widths, an ultrasound transducer (or optical-based ultrasound detection), and an aqueous coupling medium for the PA waves to propagate through.…”

Section: Introductionmentioning

confidence: 99%

Experimental design and numerical investigation of a photoacoustic sensor for a low-power, continuous-wave, laser-based frequency-domain photoacoustic microscopy

Sathiyamoorthy

Kolios

2019

J. Biomed. Opt.

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We have developed a photoacoustic (PA) sensor using a low-power, continuous-wave laser and a kHz-range microphone. The sensor is simple, flexible, cost-effective, and compatible with commercial optical microscopes. The sensor enables noncontact PA measurements through air, whereas most current existing PA techniques require an acoustic coupling liquid for detection. The PA sensor has three main components: one is the chamber that holds the sample, the second is a resonator column used to amplify the weak PA signals generated within the sample chamber, and the third is a microphone at the end of the resonator column to detect the amplified signals. The chamber size was designed to be 8 mm × 3 mm as the thermal diffusion length and viscous-thermal damping of air at room pressure and temperature are 2 and 1 mm, respectively. We numerically and experimentally examined the effect of the resonator column size on the frequency response of the PA sensor. The quality factor decreased significantly when the sample chamber size was reduced from 4 mm × 3 mm to 2 mm × 3 mm due to thermos-viscous damping of the air. The quality factor decreased by 27%, demonstrating the need for optimal design for the sample chamber and resonator column size. The system exhibited noise equivalent molecular sensitivity (NEM) per unit bandwidth (NEM∕ p Δf) of ∼19;966 Hz −1∕2 or 33 × 10 −21 mol or 33 zeptomol, which is an improvement of 2.2 times compared to the previous system design. This PA sensor has the potential for noncontact high-resolution PA imaging of materials without the need for coupling fluids. © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Probe beam deflection technique as acoustic emission directionality sensor with photoacoustic emission source

Cited by 44 publications

References 26 publications

Magneto-elasto-electroporation (MEEP): In-vitro visualization and numerical characteristics

Magneto-elasto-electroporation (MEEP): In-vitro visualization and numerical characteristics

Probe beam deflection optical imaging of thermal and mechanical phenomena resulting from nanosecond electric pulse (nsEP) exposure in-vitro

Experimental design and numerical investigation of a photoacoustic sensor for a low-power, continuous-wave, laser-based frequency-domain photoacoustic microscopy

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