Probable transfusion transmitted malaria in child of sickle cell disease (HbSS)

Agarwal, Sameer; Maini, Swati; Kelkar, Arundhati A.; Tijare, Jayshri; Shrikhande, Alka

doi:10.1007/s12098-008-0126-2

Cited by 2 publications

(2 citation statements)

References 3 publications

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“…Malaria parasite has shown to be present in blood stored at 4°C even after 28 days of storage ( 6 ). There are very few case reports published in the literature discussing TTM ( 7 – 9 ). TTM is an aspect of concern especially if the blood transfusion recipient is from vulnerable population i.e.…”

Section: Introductionmentioning

confidence: 99%

Transfusion transmissible malaria: seroprevalence of malaria parasitemia in blood donors in Garhwal region of Uttarakhand, India

Bansal,

Singh

et al. 2024

IJM

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Background and Objectives: Malaria was the first ever reported case of transfusion transmitted infection (TTI). Transfusion transmissible malaria (TTM) can result in febrile transfusion reaction in the recipient. TTM can be fatal if the blood transfu- sion recipient is from vulnerable population i.e. pregnant women or young children. Therefore, the present study was done to estimate the seroprevalence of malaria parasitemia among blood donors in Garhwal region. Materials and Methods: Study subjects were healthy blood donors who had passed the screening criteria for blood do- nation. Donors with a history of malaria were temporarily deferred for 3 months following full recovery. Screening of the donated blood units for malaria parasite was done using immunochromatography based rapid diagnostic test. Thin smear examination was performed for malaria parasite species identification. Results: A total of 1984 blood donations were screened for TTI. The seroprevalence of HBV, HCV HIV and syphilis was 0.3% (n=6), 0.25% (n=5), 0% (n=0) and 0% (n=0) respectively. The seroprevalence of malaria parasite was 0.05% (n=1). Plasmodium vivax was identified upon thin smear examination. The donor reactive for malaria parasite was a replacement donor and gave no recent history of fever or any past history of malaria. Conclusion: Meticulous donor screening combined with rapid diagnostic tests for malaria parasite is the most practical strategy to prevent TTM in Garhwal region of India.

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Section: Introductionmentioning

confidence: 99%

Transfusion transmissible malaria: seroprevalence of malaria parasitemia in blood donors in Garhwal region of Uttarakhand, India

Bansal,

Singh

et al. 2024

IJM

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“…[3] However, prevalence of markers for malaria in blood donors and incidence of TTM in patients is scantily reported, though significant risk is highlighted by frequent case reports. [4–7] Therefore, it is prudent to know the prevalence of malaria in local donor population and usefulness of currently adopted prevention strategies.…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of malaria in blood donors and multi-transfused patients in Northern India: Relevance to prevention of transfusion-transmissible malaria

Elhence¹,

Ghoshal²,

Verma³

2012

Asian J Transfus Sci

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Background:Transfusion-transmissible malaria (TTM) is a major concern in malaria endemic countries. A study was therefore conducted to know sero-prevalence of malaria in blood donors and the risk of TTM to multi-transfused patients at our hospital.Materials and Methods:Study subjects were: eligible blood donors (n = 1000), donors deferred due to history of fever in the last 3 months (n = 100), and multi-transfused patients (n = 200). Screening for malaria was done by slide microscopy, immunochromatographic rapid diagnostic test (RDT) for malaria antigen, and anti-malaria antibody by enzyme linked immunosorbent assay.Results:Malaria antibody prevalence in eligible donors and donors with history of fever, thalassemia patients, and in other multi-transfused patients was 16.9%, 22%, 6%, and 15%, respectively. None of the donors were positive for malaria on microscopic examination. None of the blood donors except one donor with history of fever, tested positive with RDT.Conclusion:Malaria antibody prevalence in blood donors at our center is high. As blood units donated by such donors have high-risk potential, special processing may be undertaken to reduce the risk of TTM.

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Probable transfusion transmitted malaria in child of sickle cell disease (HbSS)

Cited by 2 publications

References 3 publications

Transfusion transmissible malaria: seroprevalence of malaria parasitemia in blood donors in Garhwal region of Uttarakhand, India

Transfusion transmissible malaria: seroprevalence of malaria parasitemia in blood donors in Garhwal region of Uttarakhand, India

Seroprevalence of malaria in blood donors and multi-transfused patients in Northern India: Relevance to prevention of transfusion-transmissible malaria

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