Probable multigeneric resistance to macrocyclic lactone anthelmintics in cattle in New Zealand

Loveridge, B; McArthur, M; McKenna, P.B.; Mariadass, B

doi:10.1080/00480169.2003.36353

Cited by 35 publications

(15 citation statements)

References 19 publications

(20 reference statements)

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“…This data is in accordance with recent observations on the effective control of multiple resistant gastrointestinal ovine nematodes using moxidectin (Dobson et al 2001;Love and Coles 2002). However, recent reports of moxidectin resistance in Oceania (Sutherland et al 2002;Loveridge et al 2003) may indicate that the problem may become more relevant than currently considered and resistance may be inevitable. Therefore, it is imperative that the remaining effective drugs be used properly to preserve their efficacy and to delay the appearance of resistance.…”

Section: Resultssupporting

confidence: 81%

First report of multiple drug resistance in trichostrongyles affecting sheep under field conditions in Italy

et al. 2007

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Drug resistance in sheep gastrointestinal trichostrongyles is a cosmopolitan major constraint to small ruminant production. Despite reports that anthelmintic drug resistance has become common, there are limited information on the presence of drug resistance in Italy. The purpose of this study was to determine the effect of four anthelmintics to control infection in sheep in central Italy. Fifty sheep with fecal egg counts (FEC) > or =150 eggs per gram were selected on each of three farms (n = 150 total sheep) which were randomly allocated to one of five groups. Groups were treated with febantel, levamisole, ivermectin, or moxidectin while the fifth group acted as the control group. A FEC reduction test (FECRT) was conducted on each animal and the mean FEC of each treatment group was compared to that of the control group within farm. Resistance was declared when percentage reduction (R) <95% and the lower 95% confidence interval was <90%. Levamisole (mean R = 89%) resistance was found on all farms and ivermectin (mean R = 93%) resistance was found on two of the three farms. Posttreatment larval cultures showed the presence of Teladorsagia (Ostertagia) circumcincta and Trichostrongylus spp. larvae. Febantel (mean R = 96%) and moxidectin (mean R = 100%) remained effective. This study suggests that drug resistance in sheep gastrointestinal trichostrongyles is present in central Italy and a potential problem which would justify a broader nationwide geographical investigation.

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Section: Resultssupporting

confidence: 81%

First report of multiple drug resistance in trichostrongyles affecting sheep under field conditions in Italy

et al. 2007

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“…It is generally accepted that the development of anthelmintic resistance is infl uenced by the use of anthelmintics, and grazing and general livestock management practices, but information about these issues for cattle in New Zealand is mainly anecdotal or derived from relatively few case studies (Jackson et al 1987;Hosking and Watson 1991;McKenna 1991McKenna , 1996West et al 1994;Vermunt et al 1995Vermunt et al , 1996Watson et al 1995;Loveridge et al 2003;Winterrowd et al 2003;Mason and McKay 2006). Anecdotal reports from veterinary practitioners indicate a perception of an increasing incidence of resistance in intensive bull-beef-based cattle systems but there is considerable uncertainty among advisers and farmers about the effects of resistance on productivity and how best to deal with the emerging problem.…”

Section: Introductionmentioning

confidence: 99%

Anthelmintic resistance and management of nematode parasites on beef cattle-rearing farms in the North Island of New Zealand

Jackson

Rhodes²,

Pomroy

et al. 2006

New Zealand Veterinary Journal

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It is clear that in practice anthelmintic resistance is a secondary consideration to obtaining productivity advantages from the use of anthelmintics in beef cattle. Farmers' opinions were divided on many issues and the overall impression was of confused and diverse thinking regarding the principles of the use of anthelmintics. The overall outlook regarding anthelmintic resistance in cattle is bleak unless the need for integrated and long-term research activities is acted upon soon.

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“…In recent years, ML resistance in Cooperia spp. has become increasingly common in Brazil (Echevarria and Pinheiro, 1999), Argentina Fiel et al, 2001;Mejia et al, 2003), New Zealand (Familton et al, 2001;Loveridge et al, 2003;Vermunt et al, 1996), the US (Gasbarre et al, 2004) and the UK (Coles et al, 1998. To date, the first cases of suspected emerging IVM resistance in O. ostertagi are reported in New Zealand (Mason and McKay, 2006;Waghorn et al, 2006) and Argentina (Suarez and Cristel, 2007 not yet been confirmed with controlled field studies.…”

Section: Introductionmentioning

confidence: 99%

Experimental selection for ivermectin resistance in Ostertagia ostertagi in cattle

Zeveren

Casaert

Alvinerie³

et al. 2007

Veterinary Parasitology

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Recent reports of suspected ivermectin (IVM) resistance in Ostertagia ostertagi have highlighted the need for research into the mechanisms of IVM resistance. However, there are no reports of resistant field isolates of O. ostertagi, which have been characterized for molecular research. Therefore, an anthelmintic susceptible O. ostertagi population was selected for IVM resistance by repeatedly exposing the population to subtherapeutic and therapeutic levels of IVM over 10 generations. In each selection round, a group of calves was infected with the progeny of the previous IVM-selected O. ostertagi population. In the last selection round a therapeutic IVM dose (0.2 mg/kg BW) only reduced the faecal egg counts by 57% and 65% on days 7 and 14 after treatment, respectively. In contrast, the therapeutic IVM dose was 100% effective at eliminating the parental IVM-susceptible isolate. #

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Probable multigeneric resistance to macrocyclic lactone anthelmintics in cattle in New Zealand

Abstract: As well as perhaps providing the first record of resistance to any anthelmintic by T. longispicularis, the present findings may also represent the first case of resistance to macrocyclic lactone anthelmintics exhibited by more than one parasite species at a time in cattle in New Zealand.

Cited by 35 publications

References 19 publications

First report of multiple drug resistance in trichostrongyles affecting sheep under field conditions in Italy

First report of multiple drug resistance in trichostrongyles affecting sheep under field conditions in Italy

Anthelmintic resistance and management of nematode parasites on beef cattle-rearing farms in the North Island of New Zealand

Experimental selection for ivermectin resistance in Ostertagia ostertagi in cattle

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