Probable mechanism for the loss of Barr body in human female tumor with special reference to breast cancer

Ghosh, Soumendra N.; Shah, Prabhaker N.

doi:10.1016/0306-9877(81)90106-7

Cited by 5 publications

(4 citation statements)

References 23 publications

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“…Genomic DNA extracted from human breast cancer cell lines and human breast cancer and adjacent tissues was used for genotyping of IDS and G6PD polymorphisms as described previously (8,29). IDS and G6PD alleles were differentiated by PCR amplification with allele-specific primers.…”

Section: Genotyping Of Ids and G6pd Polymorphic X-linked Locimentioning

confidence: 99%

“…Earlier studies have reported loss of iX (bar body) and gain of an aX in breast and ovarian cancers (7)(8)(9)(10), showing that loss of iX and subsequent gain of an additional aX is not an uncommon phenomenon. More recent studies showed that activation or inactivation of certain X-linked genes is a predisposing factor for breast cancer (11).…”

Section: Introductionmentioning

confidence: 98%

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Aberrant Expression of X-Linked Genes RbAp46, Rsk4, and Cldn2 in Breast Cancer

Thakur

Rahman

et al. 2007

Molecular Cancer Research

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The consequence of activation status or gain/loss of an X-chromosome in terms of the expression of tumor suppressor genes or oncogenes in breast cancer has not been clearly addressed. In this study, we investigated the activation status of the X-chromosomes in a panel of human breast cancer cell lines, human breast carcinoma, and adjacent mammary tissues and a panel of murine mammary epithelial sublines ranging from low to high invasive potentials. Results show that most human breast cancer cell lines were homozygous, but both benign cell lines were heterozygous for highly polymorphic X-loci (IDS and G6PD). On the other hand, 60% of human breast carcinoma cases were heterozygous for either IDS or G6PD markers. Investigation of the activation status of heterozygous cell lines revealed the presence of only one active X-chromosome, whereas most heterozygous human breast carcinoma cases had two active X-chromosomes. Furthermore, we determined whether or not an additional active X-chromosome affects expression levels of tumor suppressor genes and oncogenes. Reverse transcription-PCR data show high expression of putative tumor suppressor genes Rsk4 and RbAp46 in 47% and 79% of breast carcinoma cases, respectively, whereas Cldn2 was down-regulated in 52% of breast cancer cases compared with normal adjacent tissues. Consistent with mRNA expression, immunostaining for these proteins also showed a similar pattern. In conclusion, our data suggest that high expression of RbAp46 is likely to have a role in the development or progression of human breast cancer. The activation status of the X-chromosome may influence the expression levels of X-linked oncogenes or tumor suppressor genes. (Mol Cancer Res 2007;5(2):171 -81)

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Section: Genotyping Of Ids and G6pd Polymorphic X-linked Locimentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Aberrant Expression of X-Linked Genes RbAp46, Rsk4, and Cldn2 in Breast Cancer

Thakur

Rahman

et al. 2007

Molecular Cancer Research

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“…20 Variations in Xi frequency have been reported with age, pregnancy, the use of oral contraceptives, fluctuations in menstrual cycle and neoplasia. [21][22][23][24][25] Moore et al found that the frequency of the sex chromatin in the nuclei of female hosts was low in malignant tissues, appearing in only about one-third of tumours in comparison to non-malignant tissues; this finding was attributed to the diverse chromosomal abnormalities that occur in malignancy. 26 Straub et al suggested that there was apparent reversion to the early embryonic state and loss of the Barr body in some female mammalian tumours wherein the condensed X chromosome may become partially or fully extended, altering its genetic activity.…”

Section: Distinct X Chromosome Perturbations In Malignancymentioning

confidence: 99%

Deciphering the Role of the Barr Body in Malignancy: An insight into head and neck cancer

Sharma

Koshy

Gupta³

et al. 2018

Sultan Qaboos Univ Med J

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X chromosome inactivation is the epitome of epigenetic regulation and long non-coding ribonucleic acid function. The differentiation status of cells has been ascribed to X chromosome activity, with two active X chromosomes generally only observed in undifferentiated or poorly differentiated cells. Recently, several studies have indicated that the reactivation of an inactive X chromosome or X chromosome multiplication correlates with the development of malignancy; however, this concept is still controversial. This review sought to shed light on the role of the X chromosome in cancer development. In particular, there is a need for further exploration of the expression patterns of X-linked genes in cancer cells, especially those in head and neck squamous cell carcinoma (HNSCC), in order to identify different prognostic subpopulations with distinct clinical implications. This article proposes a functional relationship between the loss of the Barr body and the disproportional expression of X-linked genes in HNSCC development.

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“…164 Its spreads from its site of transcription and coats the X chromosome, mediating the formation of facultative heterochromatin. 165 XIST involvement with cancer is still under investigation; however, the loss of Barr Body is a recurrent characteristic in cancer types such as breast cancer [166][167][168][169][170] and ovarian cancer, 170 which can be associated with the overexpression of X-linked genes, contributing to cancer progression. 171 …”

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confidence: 99%

Long Noncoding RNAs in HPV-Induced Oncogenesis

Goedert¹,

Plaça²,

Nunes³

et al. 2016

Advances in Tumor Virology

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Long noncoding RNAs (lncRNAs) play important roles in a wide range of oncogenic processes, including malignant transformation, epigenetic reprogramming, epithelial-to-mesenchymal transition, and metastasis development. LncRNAs induced by oncogenic viral proteins were shown to play critical roles in tumor initiation and progression. Despite this, little is known about Human papillomavirus (HPV)-induced modulation of host's lncRNAs. In this review, we gathered published information about altered lncRNAs upon HPV status (infection/protein activity), making use of descriptive research works and published gene expression microarray experiments. A diversity of lncRNAs demonstrated to be altered, including metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), H19, and maternally expressed gene 3 (MEG3). Their functions in several cancers were reviewed, indicating that they may represent potential candidates for future research on HPV-induced oncogenesis.KEY WORDS: human papillomavirus, lncRNA, cancer, ncRNA, virus CITATION: goedert et al. long noncoding rnAs in HPv-induced oncogenesis.

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Probable mechanism for the loss of Barr body in human female tumor with special reference to breast cancer

Cited by 5 publications

References 23 publications

Aberrant Expression of X-Linked Genes RbAp46, Rsk4, and Cldn2 in Breast Cancer

Aberrant Expression of X-Linked Genes RbAp46, Rsk4, and Cldn2 in Breast Cancer

Deciphering the Role of the Barr Body in Malignancy: An insight into head and neck cancer

Long Noncoding RNAs in HPV-Induced Oncogenesis

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