Probable interaction between warfarin and ginseng

Janetzky, Katherine; Morreale, Anthony P.

doi:10.1093/ajhp/54.6.692

Cited by 289 publications

(106 citation statements)

References 3 publications

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“…A 70-year old man had been receiving aspirin (325 mg/day) for three years following coronary artery bypass surgery [31]. He was admitted to hospital complaining of blurred vision one week after he had self-medicated with Ginkgo.…”

Section: Herb-drug Interactionsmentioning

confidence: 99%

Adverse effects of unconventional therapies in the elderly: A systematic review of the recent literature

Ernst

2002

AGE

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Unconventional therapies are increasingly popular, not least in populations of elderly individuals. This review summarizes the evidence regarding the risk unconventional therapies may entail for the elderly. Computerized literature searches were performed to locate all reports with original data on this topic. Most of the evidence found was anecdotal by nature and thus has obvious limitations. The results show that elderly patients can suffer harm from unconventional therapies. Herbal treatments are associated most frequently with adverse events. They can cause both direct toxicity and unwanted herb-drug interactions. Acupuncture, spinal manipulation and even massage therapy have also been implicated. Indirect risks exist if unconventional therapies are employed as a substitute for conventional treatments. It is concluded that unconventional therapies are not risk-free for elderly patients. All parties involved ought to be educated with a view of minimizing this risk, and more research is needed to increase our understanding of this area.

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Section: Herb-drug Interactionsmentioning

confidence: 99%

Adverse effects of unconventional therapies in the elderly: A systematic review of the recent literature

Ernst

2002

AGE

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“…While the mechanism of action is unknown, there is at least one case report of significant decrease in international normalized ratio in a patient on long-term warfarin therapy for a St. Jude prototype heart valve who had received 2 weeks of ginseng therapy [34]. It is theorized that there may be antiplatelet components in ginseng [35].…”

Section: Potential Drug Interactionsmentioning

confidence: 99%

Herbal medicine: Is it an alternative or an unknown? A brief review of popular herbals used by patients in a pain and symptom management practice setting

Leak

1999

Current Review of Pain

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This article will briefly discuss herbals frequently used by patients in a pain and symptom management practice setting with regard to common indications, potential side effects, and drug interactions, as well as a review of available research on each substance. An overview of the regulatory morass that continues to surround the herbal products industry will be presented. The author will examine possible ethic implications of providing care to patients utilizing alternative therapies. Future developments and studies in the field of herbal therapies will be considered.

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“…There are multiple reports of vaginal bleeding thought to be caused by ginseng's estrogenic activity [10]. The package insert for warfarin warns that an increase in the effects of warfarin is possible with concomitant use of ginseng [7], however, there are contradictory case reports that describe a drug interaction between ginseng and warfarin in which patients experienced a paradoxical decrease in the INR [11]. Concomitant use of ginseng with warfarin, heparin, aspirin, and NSAIDs is not advised [9].…”

Section: Discussionmentioning

confidence: 99%

Multifocal and Recurrent Subarachnoid Hemorrhage Due to an Herbal Supplement Containing Natural Coumarins

et al. 2007

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Probable interaction between warfarin and ginseng

Cited by 289 publications

References 3 publications

Adverse effects of unconventional therapies in the elderly: A systematic review of the recent literature

Adverse effects of unconventional therapies in the elderly: A systematic review of the recent literature

Herbal medicine: Is it an alternative or an unknown? A brief review of popular herbals used by patients in a pain and symptom management practice setting

Multifocal and Recurrent Subarachnoid Hemorrhage Due to an Herbal Supplement Containing Natural Coumarins

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