Probable Identification of an Hl-a Second-Locus Antigen Associated With a High Risk of Nasopharyngeal Carcinoma

Simons, Margaret; Wee, G. B.; Chan, Shih Huang; Shanmugaratnam, K; Day, Nicholas E.; Thé, G.B. De

doi:10.1016/s0140-6736(75)91433-6

Cited by 102 publications

(36 citation statements)

References 2 publications

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“…For example, nasopharyngeal carcinoma (NPC) is prevalent among southern Chinese and those originating from southern China, but rarely seen in northern China (Parkin et al, 2002). It has been found that the HLA alleles A*02, A*33, B*38, B*46, and B*58 and the associated haplotypes A*02-B*46 and A*33-B*58 confer increased risk for NPC, whereas A*11, A*31, B*13, B*27, B*39, and B*55 are negatively associated with the disease (Simons et al, 1975;Chan et al, 1983;Hildesheim et al, 2002;Lu et al, 2003;Hu et al, 2005). Interestingly, our study showed that the alleles and haplotypes associated (positively or negatively) with NPC displayed the distinctive distribution patterns between northern and southern Chinese (Tables 4 and 5).…”

Section: Discussionmentioning

confidence: 99%

Genetic link between Chaoshan and other Chinese Han populations: Evidence from HLA‐A and HLA‐B allele frequency distribution

Luan

et al. 2006

American J Phys Anthropol

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The genetic polymorphism of HLA-A and HLA-B loci was investigated in 505 Chaoshanese using PCR-SSP method. Among the HLA-A alleles detected, A*11 (35.64%) was most frequent, followed by A*02 (31.78%). Of 34 HLA-B alleles tested, 30 were observed, in which B*60 (21.68%), B*46 (14.46%), and B*58 (10.69%) were highly predominant. Comparison was made with other nine Chinese Han ethnic groups covering the Mainland China, Taiwan, Hong Kong, and Singapore. The high frequent alleles found in Chaoshanese were also common in other Chinese groups compared though the frequency levels varied from group to group. The phylogenic tree analysis based on the HLA-A and -B allele frequencies of all the 10 Chinese ethnic groups revealed that Chaoshanese, while clustering in general with the southern China-related Han Chinese, had the highest affinity to the Mainland Minnanese, but separated distinctively from the northern Han Chinese. The study, however, was yet to confirm the hypothesis of the Central Plains Han origin of Chaoshanese. Interestingly, the alleles (B*46, B*38, and B*58) and the related haplotypes (A*02-B*46 and A*33-B*58) that are positively associated with nasopharyngeal carcinoma (NPC), a disease prevailing predominantly among southern Chinese, were always at much higher frequencies among southern Chinese than among northern Chinese, whereas A*31 and B*13, the two alleles with highly protective effects for NPC, and the associated haplotype A*30-B*13 were predominantly high in northern Chinese. The different genetic background between northern and southern China may explain, at least partially, the prevalence of NPC among southern Chinese.

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Section: Discussionmentioning

confidence: 99%

Genetic link between Chaoshan and other Chinese Han populations: Evidence from HLA‐A and HLA‐B allele frequency distribution

Luan

et al. 2006

American J Phys Anthropol

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“…it is a eeoeraohicallv restricted disease with high incidence foci in South China, Singapore and North Africa: Tunisia is a characteristic high-NPC-incidence area (de-ThC, 1980). Second, NPC is an HLA-associated disease: individuals expressing HLA-A2 and B sin-2 (Bw46) antigens have an increased risk of this disease (Simons et al, 1974(Simons et al, , 1975Chan et al, 1983).…”

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confidence: 99%

Presence of in vivo‐activated t‐cells expressing hla‐dr molecules and il‐2 receptors in peripheral blood of patients with nasopharyngeal carcinoma

Lakhdar

Ellouz

Kammoun

et al. 1987

Intl Journal of Cancer

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Epstein-Barr Virus (EBV) is associated with two malignant diseases, African Burkitt's Lymphoma (BL) and Undifferentiated Nasopharyngeal Carcinoma (UNPC). North Africa is a geographical area with a high incidence of NPC. Our purpose in this study was to explore cell-mediated immunity of peripheral blood lymphocytes (PBL) from patients with UNPC and DNPC. We found an elevated percentage of OKT8 cells and of large granular lymphocytes (LGL) (30-35% HNK-I-positive cells) compared to PBL from healthy matched individuals. PBL from NPC patients contained 35% HLA-DR-positive and 30% Interleukin-2 (IL-2) receptor-positive circulating lymphocytes. PBL from NPC patients exhibited a normal proliferative response to phytohemagglutinin (PHA) and Concanavalin A (Con A) and an increased response to pokeweed mitogen (PWM). Natural killer (NK) activity towards K562 cells was low in our patients who, in addition, exhibited no lytic activity against HLA-matched EBV-transformed B cells. This lack of cytotoxicity against an EBV-transformed B-cell line cannot be explained by an impairment of IL-2 secretion, and is probably a result of the presence of high numbers of OKT8 suppressor T cells.

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“…Increased incidence of disease was associated with the antigen A2, and with a lack of detectable antigens at locus B. The major part of the locus B blank was later identified as a new antigen, BW46 (originally Sin2), and this antigen was shown to be associated with high risk for NPC, with a relative risk of about 2 (Simons et al, 1975). Since the identification of BW46 in 1975 a large series of unselected, newly diagnosed cases of NPC at the Singapore General Hospital have been HLA typed.…”

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confidence: 99%

HLA and nasopharyngeal carcinoma in chinese —A further study

Chan

Day

Kunaratnam

et al. 1983

Intl Journal of Cancer

108

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This paper reports the results of 8 years of HLA typing of newly diagnosed nasopharyngeal carcinoma (NPC) patients among Chinese in Singapore, and compares the HLA profile of NPC cases with that of the normal Chinese population. Earlier results had indicated an association with A2 and BW46, but the heterogeneity of the earlier case series, which contained a proportion of long-term survivors, obscured other aspects of the relationship. In this paper, the risk associated with A2 (relative risk = 1.5) and BW46 (relative risk = 1.9) is confirmed, showing a much higher relative risk in the presence of both antigens, and a risk is also demonstrated for B17 (relative risk = 2.1). Relative risks of less than unity are observed for AII (relative risk = 0.5) and B13 (relative risk = 0.5). Data from family studies indicate the importance of the haplotype A2.BW46 in determining risk for NPC.

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Probable Identification of an Hl-a Second-Locus Antigen Associated With a High Risk of Nasopharyngeal Carcinoma

Cited by 102 publications

References 2 publications

Genetic link between Chaoshan and other Chinese Han populations: Evidence from HLA‐A and HLA‐B allele frequency distribution

Genetic link between Chaoshan and other Chinese Han populations: Evidence from HLA‐A and HLA‐B allele frequency distribution

Presence of in vivo‐activated t‐cells expressing hla‐dr molecules and il‐2 receptors in peripheral blood of patients with nasopharyngeal carcinoma

HLA and nasopharyngeal carcinoma in chinese —A further study

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